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    GOLGA1 golgin A1 [ Homo sapiens (human) ]

    Gene ID: 2800, updated on 10-Dec-2024

    Summary

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    Official Symbol
    GOLGA1provided by HGNC
    Official Full Name
    golgin A1provided by HGNC
    Primary source
    HGNC:HGNC:4424
    See related
    Ensembl:ENSG00000136935 MIM:602502; AllianceGenome:HGNC:4424
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    golgin-97
    Summary
    The Golgi apparatus, which participates in glycosylation and transport of proteins and lipids in the secretory pathway, consists of a series of stacked cisternae (flattened membrane sacs). Interactions between the Golgi and microtubules are thought to be important for the reorganization of the Golgi after it fragments during mitosis. This gene encodes one of the golgins, a family of proteins localized to the Golgi. This encoded protein is associated with Sjogren's syndrome. [provided by RefSeq, Feb 2010]
    Expression
    Ubiquitous expression in testis (RPKM 12.9), skin (RPKM 6.1) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See GOLGA1 in Genome Data Viewer
    Location:
    9q33.3
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (124878275..124948043, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (137076588..137151003, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (127640554..127703362, complement)

    Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene ReSE screen-validated silencer GRCh37_chr9:127620824-127621106 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:127621747-127622248 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:127622249-127622748 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:127623737-127624360 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28993 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28994 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20270 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20271 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28995 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28996 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:127634813-127635313 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:127643063-127643616 Neighboring gene ReSE screen-validated silencer GRCh37_chr9:127646402-127646543 Neighboring gene ribosomal protein L35 Neighboring gene actin related protein 2/3 complex subunit 5 like Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:127662503-127663016 Neighboring gene RNA, U4 small nuclear 82, pseudogene Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:127665639-127666139 Neighboring gene ReSE screen-validated silencer GRCh37_chr9:127681363-127681624 Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:127702954-127703454 Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:127703455-127703955 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28998 Neighboring gene suppressor of cancer cell invasion Neighboring gene NANOG hESC enhancer GRCh37_chr9:127737373-127737931 Neighboring gene frataxin pseudogene 2 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:127806191-127806703 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:127806704-127807217 Neighboring gene uncharacterized LOC124902355

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

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    Related articles in PubMed

    1. E-cadherin transport from the trans-Golgi network in tubulovesicular carriers is selectively regulated by golgin-97. Lock JG, et al. Traffic, 2005 Dec. PMID 16262725
    2. Molecular cloning of a novel 97-kd Golgi complex autoantigen associated with Sjögren's syndrome. Griffith KJ, et al. Arthritis Rheum, 1997 Sep. PMID 9324025
    3. A host cell membrane protein, golgin-97, is essential for poxvirus morphogenesis. Alzhanova D, et al. Virology, 2007 Jun 5. PMID 17276477, Free PMC Article
    4. Autoantigen Golgin-97, an effector of Arl1 GTPase, participates in traffic from the endosome to the trans-golgi network. Lu L, et al. Mol Biol Cell, 2004 Oct. PMID 15269279, Free PMC Article
    5. FIP1/RCP binding to Golgin-97 regulates retrograde transport from recycling endosomes to the trans-Golgi network. Jing J, et al. Mol Biol Cell, 2010 Sep 1. PMID 20610657, Free PMC Article

    See all (39) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. PKD-dependent PARP12-catalyzed mono-ADP-ribosylation of Golgin-97 is required for E-cadherin transport from Golgi to plasma membrane.
      Title: PKD-dependent PARP12-catalyzed mono-ADP-ribosylation of Golgin-97 is required for E-cadherin transport from Golgi to plasma membrane.
    2. Spatial proteomics defines the content of trafficking vesicles captured by golgin tethers.
      Title: Spatial proteomics defines the content of trafficking vesicles captured by golgin tethers.
    3. FIP1/RCP binding to Golgin-97 is required for tethering and fusion of recycling endosome-derived retrograde transport vesicles to the trans-Golgi network.
      Title: FIP1/RCP binding to Golgin-97 regulates retrograde transport from recycling endosomes to the trans-Golgi network.
    4. Observational study of gene-disease association. (HuGE Navigator)
      Title: Follow-up association studies of chromosome region 9q and nonsyndromic cleft lip/palate.
    5. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
      Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
    6. Selective and essential component of the tubulovesicular carriers transporting E-cadherin out of the trans-Golgi network.
      Title: E-cadherin transport from the trans-Golgi network in tubulovesicular carriers is selectively regulated by golgin-97.
    7. The ability of the four mammalian GRIP domain proteins, p230, golgin-97, GCC88, and GCC185 to interact is reported.
      Title: The trans-Golgi network GRIP-domain proteins form alpha-helical homodimers.
    8. Data show that Arl1 regulates the membrane recruitment of Golgin-97, which plays a role in transport from the endosome to the trans-Golgi network.
      Title: Autoantigen Golgin-97, an effector of Arl1 GTPase, participates in traffic from the endosome to the trans-golgi network.
    9. Using RNA interference approach, it was demonstrated that a cellular trans-Golgi network membrane protein, golgin-97, is essential for Vaccinia virus replication.
      Title: A host cell membrane protein, golgin-97, is essential for poxvirus morphogenesis.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    retropepsin gag-pol HIV-1 PR is identified to have a physical interaction with golgin A1 (GOLGA1) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC33154

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in acrosomal vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in trans-Golgi network IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    golgin subfamily A member 1
    Names
    gap junction protein, alpha 4, 37kD
    golgi autoantigen, golgin subfamily a, 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_002077.4 → NP_002068.2  golgin subfamily A member 1

      Status: REVIEWED

      Source sequence(s)
      AL354928, AL451125
      Consensus CDS
      CCDS6860.1
      UniProtKB/Swiss-Prot
      Q5T164, Q8IYZ9, Q92805
      UniProtKB/TrEMBL
      B4DYI0
      Related
      ENSP00000362656.4, ENST00000373555.9
      Conserved Domains (3) summary
      smart00755
      Location:692 → 737
      Grip; golgin-97, RanBP2alpha,Imh1p and p230/golgin-245
      COG1196
      Location:249 → 649
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:121 → 447
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

      Range
      124878275..124948043 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047423242.1 → XP_047279198.1  golgin subfamily A member 1 isoform X1

      UniProtKB/Swiss-Prot
      Q5T164, Q8IYZ9, Q92805
      UniProtKB/TrEMBL
      B4DYI0

    2. XM_006717063.5 → XP_006717126.1  golgin subfamily A member 1 isoform X1

      See identical proteins and their annotated locations for XP_006717126.1

      UniProtKB/Swiss-Prot
      Q5T164, Q8IYZ9, Q92805
      UniProtKB/TrEMBL
      B4DYI0
      Conserved Domains (3) summary
      smart00755
      Location:692 → 737
      Grip; golgin-97, RanBP2alpha,Imh1p and p230/golgin-245
      COG1196
      Location:249 → 649
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:121 → 447
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    3. XM_005251929.5 → XP_005251986.1  golgin subfamily A member 1 isoform X1

      See identical proteins and their annotated locations for XP_005251986.1

      UniProtKB/Swiss-Prot
      Q5T164, Q8IYZ9, Q92805
      UniProtKB/TrEMBL
      B4DYI0
      Conserved Domains (3) summary
      smart00755
      Location:692 → 737
      Grip; golgin-97, RanBP2alpha,Imh1p and p230/golgin-245
      COG1196
      Location:249 → 649
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:121 → 447
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    4. XM_006717062.5 → XP_006717125.1  golgin subfamily A member 1 isoform X1

      See identical proteins and their annotated locations for XP_006717125.1

      UniProtKB/Swiss-Prot
      Q5T164, Q8IYZ9, Q92805
      UniProtKB/TrEMBL
      B4DYI0
      Conserved Domains (3) summary
      smart00755
      Location:692 → 737
      Grip; golgin-97, RanBP2alpha,Imh1p and p230/golgin-245
      COG1196
      Location:249 → 649
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:121 → 447
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    5. XM_047423241.1 → XP_047279197.1  golgin subfamily A member 1 isoform X1

      UniProtKB/Swiss-Prot
      Q5T164, Q8IYZ9, Q92805
      UniProtKB/TrEMBL
      B4DYI0

    RNA

    1. XR_929766.2 RNA Sequence

      Related
      ENST00000475407.5

    2. XR_007061280.1 RNA Sequence

    3. XR_007061279.1 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060933.1 Alternate T2T-CHM13v2.0

      Range
      137076588..137151003 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054362760.1 → XP_054218735.1  golgin subfamily A member 1 isoform X1

      UniProtKB/TrEMBL
      B4DYI0

    2. XM_054362757.1 → XP_054218732.1  golgin subfamily A member 1 isoform X1

      UniProtKB/TrEMBL
      B4DYI0

    3. XM_054362758.1 → XP_054218733.1  golgin subfamily A member 1 isoform X1

      UniProtKB/TrEMBL
      B4DYI0

    4. XM_054362761.1 → XP_054218736.1  golgin subfamily A member 1 isoform X1

      UniProtKB/TrEMBL
      B4DYI0

    5. XM_054362759.1 → XP_054218734.1  golgin subfamily A member 1 isoform X1

      UniProtKB/TrEMBL
      B4DYI0

    RNA

    1. XR_008487981.1 RNA Sequence

    2. XR_008487982.1 RNA Sequence

    3. XR_008487983.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q92805.3 GenPept UniProtKB/Swiss-Prot:Q92805

    Gene LinkOut

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