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    Syde1 synapse defective Rho GTPase homolog 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 362842, updated on 27-Nov-2024

    Summary

    Official Symbol
    Syde1provided by RGD
    Official Full Name
    synapse defective Rho GTPase homolog 1provided by RGD
    Primary source
    RGD:1305857
    See related
    EnsemblRapid:ENSRNOG00000007307 AllianceGenome:RGD:1305857
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1305857
    Summary
    Predicted to enable GTPase activator activity. Predicted to be involved in several processes, including positive regulation of trophoblast cell migration; regulation of Ras protein signal transduction; and regulation of cytoskeleton organization. Predicted to act upstream of or within several processes, including labyrinthine layer blood vessel development; synaptic vesicle docking; and synaptonemal complex assembly. Predicted to be located in cerebellar mossy fiber and cytosol. Predicted to be active in synaptic membrane. Orthologous to human SYDE1 (synapse defective Rho GTPase homolog 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Adrenal (RPKM 107.3), Heart (RPKM 104.5) and 9 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Syde1 in Genome Data Viewer
    Location:
    7q11
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (11683505..11689491)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (11032931..11038917)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (14037646..14043632)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene caspase 14 Neighboring gene olfactory receptor family 1 subfamily I member 2 Neighboring gene ilvB acetolactate synthase like Neighboring gene serine/arginine-rich splicing factor 3-like

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables GTPase activator activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables GTPase regulator activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in cerebellar mossy fiber ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in presynapse IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in synaptic membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in synaptic membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    rho GTPase-activating protein SYDE1
    Names
    protein syd-1 homolog 1
    synapse defective 1, Rho GTPase, homolog 1
    synapse defective protein 1 homolog 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001191876.1NP_001178805.1  rho GTPase-activating protein SYDE1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/Swiss-Prot
      D3ZZN9
      Related
      ENSRNOP00000009606.4, ENSRNOT00000009606.8
      Conserved Domains (2) summary
      PHA03247
      Location:48263
      PHA03247; large tegument protein UL36; Provisional
      cl02570
      Location:396601
      RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      11683505..11689491
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)