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    Bcas3 BCAS3, microtubule associated cell migration factor [ Rattus norvegicus (Norway rat) ]

    Gene ID: 363662, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Bcas3provided by RGD
    Official Full Name
    BCAS3, microtubule associated cell migration factorprovided by RGD
    Primary source
    RGD:1560788
    See related
    EnsemblRapid:ENSRNOG00000066893 AllianceGenome:RGD:1560788
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1560788
    Summary
    Predicted to enable several functions, including acetyltransferase activator activity; beta-tubulin binding activity; and histone acetyltransferase binding activity. Predicted to be involved in several processes, including cellular response to estrogen stimulus; positive regulation of endothelial cell migration; and positive regulation of transcription by RNA polymerase II. Predicted to be located in several cellular components, including cytoskeleton; euchromatin; and phagophore assembly site. Human ortholog(s) of this gene implicated in Hengel-Maroofian-Schols syndrome. Orthologous to human BCAS3 (BCAS3 microtubule associated cell migration factor). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Lung (RPKM 116.5), Kidney (RPKM 83.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Bcas3 in Genome Data Viewer
    Location:
    10q26
    Exon count:
    30
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (70711084..71170492)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (70213710..70673080)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (72756548..73271851) , (72951303..73015309)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene tetra-peptide repeat homeobox-like protein Neighboring gene large ribosomal subunit protein eL21-like Neighboring gene amyloid beta precursor protein binding protein 2 Neighboring gene protein phosphatase, Mg2+/Mn2+ dependent, 1D Neighboring gene uncharacterized LOC134480844 Neighboring gene T-box transcription factor 2 Neighboring gene T-box transcription factor 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Human BCAS3 expression in embryonic stem cells and vascular precursors suggests a role in human embryogenesis and tumor angiogenesis. Siva K, et al. PLoS One, 2007 Nov 21. PMID 18030336, Free PMC Article
    2. Breast cancer-amplified sequence 3, a target of metastasis-associated protein 1, contributes to tamoxifen resistance in premenopausal patients with breast cancer. Gururaj AE, et al. Cell Cycle, 2006 Jul. PMID 16855396
    3. Rudhira/BCAS3 is a cytoskeletal protein that controls Cdc42 activation and directional cell migration during angiogenesis. Jain M, et al. Exp Cell Res, 2012 Apr 1. PMID 22300583
    4. Estrogen induces expression of BCAS3, a novel estrogen receptor-alpha coactivator, through proline-, glutamic acid-, and leucine-rich protein-1 (PELP1). Gururaj AE, et al. Mol Endocrinol, 2007 Aug. PMID 17505058
    5. Rudhira is a cytoplasmic WD40 protein expressed in mouse embryonic stem cells and during embryonic erythropoiesis. Siva K, et al. Gene Expr Patterns, 2006 Jan. PMID 16099728

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables acetyltransferase activator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables beta-tubulin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables chromatin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables histone acetyltransferase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables histone binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables nuclear receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphatidylinositol binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in autophagy IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in cell-cell signaling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to estrogen stimulus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of catalytic activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of endothelial cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of actin cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to estrogen ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to starvation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cell leading edge ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cell periphery ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasmic microtubule ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in euchromatin ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intermediate filament cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in phagophore assembly site ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    BCAS3 microtubule associated cell migration factor
    Names
    breast carcinoma amplified sequence 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001173430.1 → NP_001166901.1  BCAS3 microtubule associated cell migration factor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/TrEMBL
      A0A8I6A420, A6HHP1
      Related
      ENSRNOP00000087925.1, ENSRNOT00000099126.2
      Conserved Domains (1) summary
      pfam12490
      Location:581 → 756
      BCAS3; Breast carcinoma amplified sequence 3

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      70711084..71170492
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039086499.2 → XP_038942427.1  BCAS3 microtubule associated cell migration factor isoform X7

      UniProtKB/TrEMBL
      A0A8I6ASA0, A0A8I6AT23
      Related
      ENSRNOP00000097649.1, ENSRNOT00000098788.2
      Conserved Domains (1) summary
      pfam12490
      Location:581 → 756
      BCAS3; Breast carcinoma amplified sequence 3

    2. XM_063269534.1 → XP_063125604.1  BCAS3 microtubule associated cell migration factor isoform X1

      UniProtKB/TrEMBL
      A0A8I6GK77

    3. XM_039086495.2 → XP_038942423.1  BCAS3 microtubule associated cell migration factor isoform X3

      UniProtKB/TrEMBL
      A0A8I6ASA0, A0A8I6G9E5
      Related
      ENSRNOP00000082383.1, ENSRNOT00000104458.2
      Conserved Domains (1) summary
      pfam12490
      Location:581 → 756
      BCAS3; Breast carcinoma amplified sequence 3

    4. XM_039086494.2 → XP_038942422.1  BCAS3 microtubule associated cell migration factor isoform X2

      UniProtKB/TrEMBL
      A6HHP1
      Conserved Domains (1) summary
      pfam12490
      Location:581 → 756
      BCAS3; Breast carcinoma amplified sequence 3

    5. XM_039086497.2 → XP_038942425.1  BCAS3 microtubule associated cell migration factor isoform X5

      UniProtKB/TrEMBL
      A0A8I6ASA0
      Conserved Domains (1) summary
      pfam12490
      Location:521 → 741
      BCAS3; Breast carcinoma amplified sequence 3

    6. XM_063269537.1 → XP_063125607.1  BCAS3 microtubule associated cell migration factor isoform X9

      Related
      ENSRNOP00000094777.1, ENSRNOT00000095630.2

    7. XM_039086498.2 → XP_038942426.1  BCAS3 microtubule associated cell migration factor isoform X6

      UniProtKB/TrEMBL
      A0A8I6A420, A6HHP1
      Conserved Domains (1) summary
      pfam12490
      Location:581 → 756
      BCAS3; Breast carcinoma amplified sequence 3

    8. XM_039086496.2 → XP_038942424.1  BCAS3 microtubule associated cell migration factor isoform X4

      UniProtKB/TrEMBL
      A0A8I6APN6, A0A8I6ASA0
      Related
      ENSRNOP00000096642.1, ENSRNOT00000119090.2
      Conserved Domains (1) summary
      pfam12490
      Location:521 → 741
      BCAS3; Breast carcinoma amplified sequence 3

    9. XM_039086500.2 → XP_038942428.1  BCAS3 microtubule associated cell migration factor isoform X8

      UniProtKB/TrEMBL
      A0A8I6ASA0
      Conserved Domains (1) summary
      pfam12490
      Location:521 → 741
      BCAS3; Breast carcinoma amplified sequence 3

    10. XM_063269533.1 → XP_063125603.1  BCAS3 microtubule associated cell migration factor isoform X1

      UniProtKB/TrEMBL
      A0A8I6GK77
      Related
      ENSRNOP00000092518.1, ENSRNOT00000096172.2

    11. XM_063269535.1 → XP_063125605.1  BCAS3 microtubule associated cell migration factor isoform X6

      UniProtKB/TrEMBL
      A0A8I6A420

    12. XM_063269536.1 → XP_063125606.1  BCAS3 microtubule associated cell migration factor isoform X8

    RNA

    1. XR_010055214.1 RNA Sequence

    2. XR_010055215.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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