Cyp4f4 cytochrome P450, family 4, subfamily f, polypeptide 4 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Cyp4f4provided by RGD
Official Full Name: cytochrome P450, family 4, subfamily f, polypeptide 4provided by RGD
Primary source: RGD:708363
See related: EnsemblRapid:ENSRNOG00000032895 AllianceGenome:RGD:708363
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables arachidonate monooxygenase activity; heme binding activity; and leukotriene-B4 20-monooxygenase activity. Involved in icosanoid catabolic process; omega-hydroxylase P450 pathway; and response to 3-methylcholanthrene. Predicted to be located in endoplasmic reticulum membrane. Biomarker of hypertrophic cardiomyopathy. Orthologous to human CYP4F11 (cytochrome P450 family 4 subfamily F member 11). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Liver (RPKM 346.8) and Kidney (RPKM 14.4) See more
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Genomic context

Location:: 7q11

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (12367711..12384010)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (11717208..11733507)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (14891062..14907250)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CYP4Fs are regionally distributed in the spontaneously hypertensive rat (SHR) kidney with CYP4F1, 4F4, and 4F5 being more highly expressed in the renal cortex than medulla while CYP4F6 shows higher medullary expression.
Title: Renal localization, expression, and developmental regulation of P450 4F cytochromes in three substrains of spontaneously hypertensive rats.

Submit: New GeneRIF Correction

General gene information

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Markers

AF045318 (e-PCR)
- UniSTS:64520

RH130999 (e-PCR)
- UniSTS:214282

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables arachidonate monooxygenase activity	IBA Inferred from Biological aspect of Ancestor more info
enables arachidonate monooxygenase activity	IDA Inferred from Direct Assay more info	PubMed
enables arachidonate omega-hydroxylase activity	IEA Inferred from Electronic Annotation more info
enables heme binding	IDA Inferred from Direct Assay more info	PubMed
enables heme binding	IEA Inferred from Electronic Annotation more info
enables iron ion binding	IEA Inferred from Electronic Annotation more info
enables leukotriene-B4 20-monooxygenase activity	IBA Inferred from Biological aspect of Ancestor more info
enables leukotriene-B4 20-monooxygenase activity	IDA Inferred from Direct Assay more info	PubMed
enables monooxygenase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in arachidonate metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in leukotriene B4 catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in leukotriene B4 catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in omega-hydroxylase P450 pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in prostaglandin catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in response to 3-methylcholanthrene	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: cytochrome P450 4F4

Names: CYPIVF4; leukotriene-B4 20-monooxygenase

NP_775146.1

EC 1.14.14.94

XP_063119146.1

EC 1.14.14.94

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.