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    Zzz3 zinc finger, ZZ-type containing 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 310958, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Zzz3provided by RGD
    Official Full Name
    zinc finger, ZZ-type containing 3provided by RGD
    Primary source
    RGD:1565468
    See related
    EnsemblRapid:ENSRNOG00000050321 AllianceGenome:RGD:1565468
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1565468
    Summary
    Predicted to enable histone reader activity; lysine-acetylated histone binding activity; and methylated histone binding activity. Predicted to be involved in several processes, including regulation of embryonic development; regulation of transcription by RNA polymerase II; and regulation of tubulin deacetylation. Predicted to be located in nucleolus and nucleoplasm. Predicted to be part of ATAC complex. Orthologous to human ZZZ3 (zinc finger ZZ-type containing 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 137.3), Thymus (RPKM 118.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Zzz3 in Genome Data Viewer
    Location:
    2q45
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (243990305..244057251)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (241330366..241397308)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (257602924..257671783)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene mitoguardin 1 Neighboring gene uncharacterized LOC120100974 Neighboring gene ubiquitin specific peptidase 33 Neighboring gene uncharacterized LOC134485695 Neighboring gene uncharacterized LOC120100975 Neighboring gene adenylate kinase 5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The ZZ-type zinc finger of ZZZ3 modulates the ATAC complex-mediated histone acetylation and gene activation. Mi W, et al. Nat Commun, 2018 Sep 14. PMID 30217978, Free PMC Article
    2. The ATAC acetyl transferase complex controls mitotic progression by targeting non-histone substrates. Orpinell M, et al. EMBO J, 2010 Jul 21. PMID 20562830, Free PMC Article
    3. ATAC-king the complexity of SAGA during evolution. Spedale G, et al. Genes Dev, 2012 Mar 15. PMID 22426530, Free PMC Article
    4. ATAC and Mediator coactivators form a stable complex and regulate a set of non-coding RNA genes. Krebs AR, et al. EMBO Rep, 2010 Jul. PMID 20508642, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables histone reader activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables lysine-acetylated histone binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables methylated histone binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in chromatin organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cell cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cell division ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of embryonic development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of tubulin deacetylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of ATAC complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    ZZ-type zinc finger-containing protein 3
    Names
    zinc finger, ZZ domain containing 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001134549.2 → NP_001128021.2  ZZ-type zinc finger-containing protein 3

      See identical proteins and their annotated locations for NP_001128021.2

      Status: VALIDATED

      Source sequence(s)
      FM103952, FN806367, JAXUCZ010000002
      UniProtKB/TrEMBL
      M0R9X4
      Related
      ENSRNOP00000066308.4, ENSRNOT00000071770.4
      Conserved Domains (2) summary
      cd02341
      Location:827 → 877
      ZZ_ZZZ3; Zinc finger, ZZ type. Zinc finger present in ZZZ3 (ZZ finger containing 3) and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding.
      pfam00249
      Location:661 → 709
      Myb_DNA-binding; Myb-like DNA-binding domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      243990305..244057251
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039102495.2 → XP_038958423.1  ZZ-type zinc finger-containing protein 3 isoform X4

      UniProtKB/TrEMBL
      A0A0G2JZX0
      Related
      ENSRNOP00000101189.1, ENSRNOT00000143793.1
      Conserved Domains (2) summary
      cd00167
      Location:161 → 209
      SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
      cd02341
      Location:327 → 377
      ZZ_ZZZ3; Zinc finger, ZZ type. Zinc finger present in ZZZ3 (ZZ finger containing 3) and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding.

    2. XM_063281986.1 → XP_063138056.1  ZZ-type zinc finger-containing protein 3 isoform X4

      UniProtKB/TrEMBL
      A0A0G2JZX0

    3. XM_063281988.1 → XP_063138058.1  ZZ-type zinc finger-containing protein 3 isoform X4

      UniProtKB/TrEMBL
      A0A0G2JZX0

    4. XM_063281987.1 → XP_063138057.1  ZZ-type zinc finger-containing protein 3 isoform X4

      UniProtKB/TrEMBL
      A0A0G2JZX0
      Related
      ENSRNOP00000071216.3, ENSRNOT00000080993.3

    5. XM_006233491.5 → XP_006233553.1  ZZ-type zinc finger-containing protein 3 isoform X1

      UniProtKB/TrEMBL
      M0R9X4
      Conserved Domains (3) summary
      smart00717
      Location:660 → 710
      SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
      cd02341
      Location:826 → 876
      ZZ_ZZZ3; Zinc finger, ZZ type. Zinc finger present in ZZZ3 (ZZ finger containing 3) and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding.
      pfam00249
      Location:660 → 707
      Myb_DNA-binding; Myb-like DNA-binding domain

    6. XM_039102493.2 → XP_038958421.1  ZZ-type zinc finger-containing protein 3 isoform X2

      Conserved Domains (1) summary
      NF033647
      Location:302 → 430
      adhesin_LEA; LEA family epithelial adhesin N-terminal domain

    7. XM_039102494.2 → XP_038958422.1  ZZ-type zinc finger-containing protein 3 isoform X3

      Conserved Domains (1) summary
      NF033647
      Location:302 → 430
      adhesin_LEA; LEA family epithelial adhesin N-terminal domain
    Nucleotide Protein Strain
    Heading Accession and Version

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