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    Nup160 nucleoporin 160 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 311182, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Nup160provided by RGD
    Official Full Name
    nucleoporin 160provided by RGD
    Primary source
    RGD:1311052
    See related
    EnsemblRapid:ENSRNOG00000028215 AllianceGenome:RGD:1311052
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be a structural constituent of nuclear pore. Predicted to be involved in mRNA export from nucleus and nephron development. Predicted to be located in kinetochore and nuclear envelope. Predicted to be part of nuclear pore outer ring. Human ortholog(s) of this gene implicated in nephrotic syndrome type 19. Orthologous to human NUP160 (nucleoporin 160). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Thymus (RPKM 99.1), Spleen (RPKM 86.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Nup160 in Genome Data Viewer
    Location:
    3q24
    Exon count:
    36
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (97120723..97183227)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (76665786..76729296)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (79496239..79562163)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134486405 Neighboring gene uncharacterized LOC102555600 Neighboring gene uncharacterized LOC103691844 Neighboring gene small nucleolar RNA SNORA44 Neighboring gene formin binding protein 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Novel vertebrate nucleoporins Nup133 and Nup160 play a role in mRNA export. Vasu S, et al. J Cell Biol, 2001 Oct 29. PMID 11684705, Free PMC Article
    2. An evolutionarily conserved NPC subcomplex, which redistributes in part to kinetochores in mammalian cells. Belgareh N, et al. J Cell Biol, 2001 Sep 17. PMID 11564755, Free PMC Article
    3. Mutations in multiple components of the nuclear pore complex cause nephrotic syndrome. Braun DA, et al. J Clin Invest, 2018 Oct 1. PMID 30179222, Free PMC Article
    4. Regulation of mRNA trafficking by nuclear pore complexes. Bonnet A, et al. Genes (Basel), 2014 Sep 2. PMID 25184662, Free PMC Article
    5. ELYS is a dual nucleoporin/kinetochore protein required for nuclear pore assembly and proper cell division. Rasala BA, et al. Proc Natl Acad Sci U S A, 2006 Nov 21. PMID 17098863, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables structural constituent of nuclear pore IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural constituent of nuclear pore ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in mRNA export from nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in nephron development ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in kinetochore ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear envelope ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of nuclear pore IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of nuclear pore ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of nuclear pore outer ring ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    nuclear pore complex protein Nup160

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107744.1 → NP_001101214.1  nuclear pore complex protein Nup160

      See identical proteins and their annotated locations for NP_001101214.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473949
      UniProtKB/TrEMBL
      A0A8I5ZXX5, A6HN68
      Related
      ENSRNOP00000083879.1, ENSRNOT00000112842.2
      Conserved Domains (1) summary
      pfam11715
      Location:28 → 520
      Nup160; Nucleoporin Nup120/160

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      97120723..97183227
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039104890.2 → XP_038960818.1  nuclear pore complex protein Nup160 isoform X1

      UniProtKB/TrEMBL
      D3ZBL6
      Conserved Domains (1) summary
      pfam11715
      Location:28 → 543
      Nup160; Nucleoporin Nup120/160

    2. XM_039104889.2 → XP_038960817.1  nuclear pore complex protein Nup160 isoform X1

      UniProtKB/TrEMBL
      D3ZBL6
      Conserved Domains (1) summary
      pfam11715
      Location:28 → 543
      Nup160; Nucleoporin Nup120/160

    3. XM_039104891.2 → XP_038960819.1  nuclear pore complex protein Nup160 isoform X2

    Nucleotide Protein Strain
    Heading Accession and Version

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