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    Arl5c ARF like GTPase 5C [ Rattus norvegicus (Norway rat) ]

    Gene ID: 497990, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Arl5cprovided by RGD
    Official Full Name
    ARF like GTPase 5Cprovided by RGD
    Primary source
    RGD:1563128
    See related
    AllianceGenome:RGD:1563128
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1563128
    Summary
    Predicted to enable GTP binding activity. Predicted to be involved in intracellular protein transport; protein localization to Golgi membrane; and vesicle-mediated transport. Predicted to be active in trans-Golgi network. Orthologous to human ARL5C (ARF like GTPase 5C). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 581.0) and Spleen (RPKM 153.5) See more
    Orthologs
    human mouse all
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    Genomic context

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    See Arl5c in Genome Data Viewer
    Location:
    10q31
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (83481540..83492915, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (82985213..82993425, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (85939836..85948131, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene transfer RNA cysteine (anticodon GCA) 36 Neighboring gene transfer RNA cysteine (anticodon GCA) 37 Neighboring gene uncharacterized LOC134480866 Neighboring gene calcium voltage-gated channel auxiliary subunit beta 1 Neighboring gene ribosomal protein L19 Neighboring gene SH3 and cysteine rich domain 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables GTP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in intracellular protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein localization to Golgi membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in trans-Golgi network IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    putative ADP-ribosylation factor-like protein 5C
    Names
    ADP-ribosylation factor like GTPase 5C
    ADP-ribosylation factor-like 5C

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001109046.2 → NP_001102516.1  putative ADP-ribosylation factor-like protein 5C

      See identical proteins and their annotated locations for NP_001102516.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/TrEMBL
      A0A0G2JUX1, A6HIP1, D3ZES1
      Conserved Domains (1) summary
      cd04153
      Location:3 → 175
      Arl5_Arl8; Arf-like 5 (Arl5) and 8 (Arl8) GTPases

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      83481540..83492915 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039086633.2 → XP_038942561.1  putative ADP-ribosylation factor-like protein 5C isoform X2

      Conserved Domains (1) summary
      cl38936
      Location:79 → 189
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    2. XM_039086632.2 → XP_038942560.1  putative ADP-ribosylation factor-like protein 5C isoform X1

      Conserved Domains (1) summary
      cl38936
      Location:79 → 217
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    3. XM_063269660.1 → XP_063125730.1  putative ADP-ribosylation factor-like protein 5C isoform X4

      UniProtKB/TrEMBL
      A0A0G2JUX1

    4. XM_039086634.2 → XP_038942562.1  putative ADP-ribosylation factor-like protein 5C isoform X3

      Conserved Domains (1) summary
      cl38936
      Location:79 → 130
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    Nucleotide Protein Strain
    Heading Accession and Version

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