Tacc1 transforming, acidic coiled-coil containing protein 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Tacc1provided by RGD
Official Full Name: transforming, acidic coiled-coil containing protein 1provided by RGD
Primary source: RGD:1303120
See related: EnsemblRapid:ENSRNOG00000016423 AllianceGenome:RGD:1303120
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Tacc1a
Summary: This gene encodes a member of the transforming, acidic coiled-coil (TACC) family of proteins. Members of this family are centrosomal proteins that interact with microtubules and tubulin. TACC proteins are thought to be involved in centrosome/mitotic spindle dynamics and gene regulation. [provided by RefSeq, Jul 2008]
Expression: Biased expression in Adrenal (RPKM 234.3), Spleen (RPKM 204.6) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 16q12.4

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	16	NC_086034.1 (73515016..73598395)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	16	NC_051351.1 (66812232..66895736)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	16	NC_005115.4 (71596970..71681126)

Chromosome 16 - NC_086034.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

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Markers

D16Got66 (e-PCR)
- UniSTS:114435

BE113007 (e-PCR)
- UniSTS:246615

AI008689 (e-PCR)
- UniSTS:261721

RH140240 (e-PCR)
- UniSTS:222319

RH132384 (e-PCR)
- UniSTS:215667

AA956912 (e-PCR)
- UniSTS:247674

RH137203 (e-PCR)
- UniSTS:219291

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables nuclear estrogen receptor binding	ISO Inferred from Sequence Orthology more info
enables nuclear glucocorticoid receptor binding	ISO Inferred from Sequence Orthology more info
enables nuclear receptor binding	ISO Inferred from Sequence Orthology more info
enables nuclear receptor coactivator activity	ISO Inferred from Sequence Orthology more info
enables nuclear retinoic acid receptor binding	ISO Inferred from Sequence Orthology more info
enables nuclear retinoid X receptor binding	ISO Inferred from Sequence Orthology more info
enables nuclear thyroid hormone receptor binding	ISO Inferred from Sequence Orthology more info
enables peroxisome proliferator activated receptor binding	ISO Inferred from Sequence Orthology more info
enables protein domain specific binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in cerebral cortex development	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cerebral cortex development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within interkinetic nuclear migration	ISO Inferred from Sequence Orthology more info
involved_in microtubule cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within microtubule cytoskeleton organization	ISO Inferred from Sequence Orthology more info
involved_in mitotic spindle organization	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within neurogenesis	ISO Inferred from Sequence Orthology more info
involved_in nuclear migration	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of microtubule-based process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: transforming acidic coiled-coil-containing protein 1

Names: transforming, acidic coiled-coil containing protein 1a

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001004107.4 → NP_001004107.1 transforming acidic coiled-coil-containing protein 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000016

UniProtKB/TrEMBL

D4A927

Related

ENSRNOP00000030626.4, ENSRNOT00000035347.7

Conserved Domains (3) summary

pfam05010
Location:566 → 765

TACC; Transforming acidic coiled-coil-containing protein (TACC)

pfam09403
Location:671 → 764

FadA; Adhesion protein FadA

cl21478
Location:573 → 658

ATP-synt_B; ATP synthase B/B' CF(0)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086034.1 Reference GRCr8

Range

73515016..73598395

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039094561.2 → XP_038950489.2 transforming acidic coiled-coil-containing protein 1 isoform X7
XM_063275446.1 → XP_063131516.1 transforming acidic coiled-coil-containing protein 1 isoform X6
XM_017600146.3 → XP_017455635.1 transforming acidic coiled-coil-containing protein 1 isoform X1

UniProtKB/TrEMBL

D4A927
XM_039094559.2 → XP_038950487.1 transforming acidic coiled-coil-containing protein 1 isoform X2

UniProtKB/TrEMBL

A0A8I6AHG9, D4A927

Related

ENSRNOP00000092100.2, ENSRNOT00000106912.2

Conserved Domains (1) summary

pfam05010
Location:536 → 735

TACC; Transforming acidic coiled-coil-containing protein (TACC)
XM_063275445.1 → XP_063131515.1 transforming acidic coiled-coil-containing protein 1 isoform X5
XM_063275444.1 → XP_063131514.1 transforming acidic coiled-coil-containing protein 1 isoform X4
XM_017600145.3 → XP_017455634.1 transforming acidic coiled-coil-containing protein 1 isoform X3

UniProtKB/TrEMBL

A0A0G2K9K2, D4A927

Related

ENSRNOP00000075027.1, ENSRNOT00000088462.3
XM_006253318.5 → XP_006253380.1 transforming acidic coiled-coil-containing protein 1 isoform X8

UniProtKB/TrEMBL

A0A8I5Y233

Related

ENSRNOP00000078214.1, ENSRNOT00000097760.2

Conserved Domains (1) summary

pfam05010
Location:161 → 360

TACC; Transforming acidic coiled-coil-containing protein (TACC)
XM_063275443.1 → XP_063131513.1 transforming acidic coiled-coil-containing protein 1 isoform X3

UniProtKB/TrEMBL

A0A0G2K9K2