Adcyap1 adenylate cyclase activating polypeptide 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Adcyap1provided by RGD
Official Full Name: adenylate cyclase activating polypeptide 1provided by RGD
Primary source: RGD:2037
See related: EnsemblRapid:ENSRNOG00000049882 AllianceGenome:RGD:2037
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Pacap
Summary: Enables neuropeptide hormone activity; pituitary adenylate cyclase activating polypeptide activity; and pituitary adenylate cyclase-activating polypeptide receptor binding activity. Involved in several processes, including negative regulation of acute inflammatory response; positive regulation of cell communication; and positive regulation of macromolecule metabolic process. Located in extracellular space and terminal bouton. Is active in neuronal dense core vesicle lumen. Used to study Parkinsonism and acute necrotizing pancreatitis. Biomarker of cystitis. Human ortholog(s) of this gene implicated in alcohol dependence. Orthologous to human ADCYAP1 (adenylate cyclase activating polypeptide 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Spleen (RPKM 25.5), Brain (RPKM 22.0) and 1 other tissue See more
Orthologs: human mouse all
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Genomic context

Location:: 9q38

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	9	NC_086027.1 (120550236..120569096, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	9	NC_051344.1 (113102632..113122500, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	9	NC_005108.4 (121705897..121725736, complement)

Chromosome 9 - NC_086027.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Protective effect of pituitary adenylate cyclase activating polypeptide in diabetic keratopathy.
Title: Protective effect of pituitary adenylate cyclase activating polypeptide in diabetic keratopathy.
Early Alterations of PACAP and VIP Expression in the Female Rat Brain Following Spinal Cord Injury.
Title: Early Alterations of PACAP and VIP Expression in the Female Rat Brain Following Spinal Cord Injury.
Unveiling adcyap1 as a protective factor linking pain and nerve regeneration through single-cell RNA sequencing of rat dorsal root ganglion neurons.
Title: Unveiling adcyap1 as a protective factor linking pain and nerve regeneration through single-cell RNA sequencing of rat dorsal root ganglion neurons.
Downregulation of PACAP and the PAC1 Receptor in the Basal Ganglia, Substantia Nigra and Centrally Projecting Edinger-Westphal Nucleus in the Rotenone model of Parkinson's Disease.
Title: Downregulation of PACAP and the PAC1 Receptor in the Basal Ganglia, Substantia Nigra and Centrally Projecting Edinger-Westphal Nucleus in the Rotenone model of Parkinson's Disease.
PACAP inhibition alleviates neuropathic pain by modulating Nav1.7 through the MAPK/ERK signaling pathway in a rat model of chronic constriction injury.
Title: PACAP inhibition alleviates neuropathic pain by modulating Nav1.7 through the MAPK/ERK signaling pathway in a rat model of chronic constriction injury.
Inhibition of the retinal orexin receptors affects the hypothalamic-pituitary-gonadal axis through retinal pituitary adenylate cyclase activating polypeptide (PACAP) in male Wistar rats.
Title: Inhibition of the retinal orexin receptors affects the hypothalamic-pituitary-gonadal axis through retinal pituitary adenylate cyclase activating polypeptide (PACAP) in male Wistar rats.
Temporal alterations of pituitary adenylate cyclase activating polypeptide and its receptors in a rat model induced by recurrent chemical stimulations: Relevant to chronic migraine.
Title: Temporal alterations of pituitary adenylate cyclase activating polypeptide and its receptors in a rat model induced by recurrent chemical stimulations: Relevant to chronic migraine.
Pituitary adenylate cyclase-activating polypeptide type 1 receptor within the nucleus accumbens core mediates excessive alcohol drinking in alcohol-preferring rats.
Title: Pituitary adenylate cyclase-activating polypeptide type 1 receptor within the nucleus accumbens core mediates excessive alcohol drinking in alcohol-preferring rats.
Protective Effects of PACAP in a Rat Model of Diabetic Neuropathy.
Title: Protective Effects of PACAP in a Rat Model of Diabetic Neuropathy.
Pituitary adenylate cyclase-activating polypeptide (PACAP) modulates dependence-induced alcohol drinking and anxiety-like behavior in male rats.
Title: Pituitary adenylate cyclase-activating polypeptide (PACAP) modulates dependence-induced alcohol drinking and anxiety-like behavior in male rats.

Submit: New GeneRIF Correction See all GeneRIFs (134)

General gene information

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Markers

RH143645 (e-PCR)
- UniSTS:232891

RH139550 (e-PCR)
- UniSTS:221635

BE118210 (e-PCR)
- UniSTS:248800

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables neuropeptide hormone activity	IBA Inferred from Biological aspect of Ancestor more info
enables neuropeptide hormone activity	IDA Inferred from Direct Assay more info	PubMed
enables neuropeptide hormone activity	IEA Inferred from Electronic Annotation more info
enables neuropeptide hormone activity	ISO Inferred from Sequence Orthology more info
enables peptide hormone receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables peptide hormone receptor binding	ISO Inferred from Sequence Orthology more info
enables peptide hormone receptor binding	ISS Inferred from Sequence or Structural Similarity more info
enables pituitary adenylate cyclase activating polypeptide activity	IBA Inferred from Biological aspect of Ancestor more info
enables pituitary adenylate cyclase activating polypeptide activity	IDA Inferred from Direct Assay more info	PubMed
enables pituitary adenylate cyclase activating polypeptide activity	IEA Inferred from Electronic Annotation more info
enables pituitary adenylate cyclase activating polypeptide activity	ISO Inferred from Sequence Orthology more info
enables pituitary adenylate cyclase-activating polypeptide receptor binding	IDA Inferred from Direct Assay more info	PubMed
enables signaling receptor binding	ISO Inferred from Sequence Orthology more info
enables type 1 vasoactive intestinal polypeptide receptor binding	ISO Inferred from Sequence Orthology more info
enables type 1 vasoactive intestinal polypeptide receptor binding	ISS Inferred from Sequence or Structural Similarity more info
enables type 2 vasoactive intestinal polypeptide receptor binding	ISO Inferred from Sequence Orthology more info
enables type 2 vasoactive intestinal polypeptide receptor binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in adenylate cyclase-modulating G protein-coupled receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in adenylate cyclase-modulating G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in behavioral fear response	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to glucocorticoid stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in histamine secretion	IDA Inferred from Direct Assay more info	PubMed
involved_in insulin secretion	IEA Inferred from Electronic Annotation more info
involved_in insulin secretion	ISO Inferred from Sequence Orthology more info
involved_in insulin secretion	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of GTPase activity	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of acute inflammatory response to antigenic stimulus	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of acute inflammatory response to non-antigenic stimulus	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of cell cycle	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of cell cycle	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of glial cell proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of muscle cell apoptotic process	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of potassium ion transport	IDA Inferred from Direct Assay more info	PubMed
involved_in neuron projection development	IBA Inferred from Biological aspect of Ancestor more info
involved_in neuron projection development	IDA Inferred from Direct Assay more info	PubMed
involved_in neuron projection development	ISO Inferred from Sequence Orthology more info
involved_in neuropeptide signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in neuropeptide signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in neuropeptide signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in neuropeptide signaling pathway	NAS Non-traceable Author Statement more info	PubMed
involved_in ovarian follicle development	IDA Inferred from Direct Assay more info	PubMed
involved_in pituitary gland development	IEP Inferred from Expression Pattern more info	PubMed
involved_in positive regulation of ERK1 and ERK2 cascade	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of ERK1 and ERK2 cascade	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of GTPase activity	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of GTPase activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cAMP/PKA signal transduction	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of cell population proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of chemokine (C-C motif) ligand 5 production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cold-induced thermogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cold-induced thermogenesis	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in positive regulation of cytosolic calcium ion concentration	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of gene expression	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of growth hormone secretion	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of interleukin-6 production	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of neuron projection development	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of neuron projection development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of protein kinase activity	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of protein kinase activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of somatostatin secretion	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of synaptic transmission, glutamatergic	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in regulation of G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in regulation of G protein-coupled receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of oligodendrocyte progenitor proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of postsynaptic membrane potential	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of protein localization	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of protein localization	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of protein localization	IEA Inferred from Electronic Annotation more info
involved_in regulation of protein localization	ISO Inferred from Sequence Orthology more info
involved_in regulation of protein phosphorylation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in response to ethanol	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to starvation	IEP Inferred from Expression Pattern more info	PubMed
involved_in vasodilation	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in cytosol	TAS Traceable Author Statement more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
is_active_in extracellular space	ISO Inferred from Sequence Orthology more info
is_active_in neuron projection	IBA Inferred from Biological aspect of Ancestor more info
is_active_in neuronal dense core vesicle lumen	IDA Inferred from Direct Assay more info	PubMed
is_active_in perikaryon	IBA Inferred from Biological aspect of Ancestor more info
located_in terminal bouton	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: pituitary adenylate cyclase-activating polypeptide

Names: adenylate cyclase activating polypeptide 1 (pituitary); pituitary adenylate cyclase activating polypeptide 1; pituitary adenylate cyclase-activating polypeptide precursor (Pacap)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.