Gabrr1 gamma-aminobutyric acid type A receptor subunit rho 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Gabrr1provided by RGD
Official Full Name: gamma-aminobutyric acid type A receptor subunit rho 1provided by RGD
Primary source: RGD:61900
See related: EnsemblRapid:ENSRNOG00000007603 AllianceGenome:RGD:61900
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables several functions, including GABA-A receptor activity; GABA-gated chloride ion channel activity; and identical protein binding activity. Predicted to be involved in chloride transmembrane transport and modulation of chemical synaptic transmission. Predicted to be located in plasma membrane. Predicted to be part of GABA-A receptor complex. Predicted to be active in several cellular components, including GABA-ergic synapse; glutamatergic synapse; and presynaptic membrane. Orthologous to human GABRR1 (gamma-aminobutyric acid type A receptor subunit rho1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Muscle (RPKM 7.8), Kidney (RPKM 1.8) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 5q21

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (52320475..52357549)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (47524151..47561228)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (48374048..48411170)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

GABACR and mGluR1 have roles in contrast response functions of Sprague-Dawley and P23H rat retinal ganglion cells
Title: Effects of GABACR and mGluR1 antagonists on contrast response functions of Sprague-Dawley and P23H rat retinal ganglion cells.
Gabrr1 containing gamma2(R43Q) are addressed to the cell membrane but undergo clathrin-mediated dynamin-dependent endocytosis
Title: Agonist-dependent endocytosis of γ-aminobutyric acid type A (GABAA) receptors revealed by a γ2(R43Q) epilepsy mutation.
In the stratum griseum superficiale, primarily GABAergic neurons express GABA(C) receptors.
Title: GABA(C) receptors are expressed in GABAergic and non-GABAergic neurons of the rat superior colliculus and visual cortex.
GABAergic neurons in the SGS express GABAC receptors whereas the majority of tectothalamic CB-ir neurons and intrinsicall
Title: Contribution of GABA(C) receptors to inhibition in the rodent accessory optic system.
Suggest that GABA(C)-receptor rho subunit stimulation activates PKA via A-kinase anchoring protein 220(AKAP220).
Title: GABAC-receptor stimulation activates cAMP-dependent protein kinase via A-kinase anchoring protein 220.
The expression of GABA(C) receptors in the cerebellum adds a new dimension to the regulation of GABAergic neurotransmission
Title: Expression of GABArho subunits during rat cerebellum development.
Tax1BP1 and GABA(C) receptors were co-expressed in both synaptic layers of the retina, indicating that Tax1BP1 is a component of GABA(C) receptor-containing signal complexes.
Title: Tax1-binding protein 1 is expressed in the retina and interacts with the GABA(C) receptor rho1 subunit.
The rho1 and rho2 products appeared to be developmentally regulated; they were found to be more pronounced in adulthood.
Title: gamma-Aminobutyric acidA rho receptor subunits in the developing rat hippocampus.
GABA(C) receptors are specifically involved in aspects of visual image motion processing in the rat brain.
Title: GABA receptor rho subunit expression in the developing rat brain.
All neurons examined in catecholamine and serotonin neurons in the brainstem were immunoreactive for the GABA(B)R1 subunit.
Title: GABAB receptor subunits, R1 and R2, in brainstem catecholamine and serotonin neurons.

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables GABA receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables GABA-A receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables GABA-A receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables GABA-A receptor activity	IEA Inferred from Electronic Annotation more info
enables GABA-gated chloride ion channel activity	IDA Inferred from Direct Assay more info	PubMed
contributes_to chloride channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables chloride channel activity	IEA Inferred from Electronic Annotation more info
enables extracellular ligand-gated monoatomic ion channel activity	IEA Inferred from Electronic Annotation more info
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential	IEA Inferred from Electronic Annotation more info
enables ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein domain specific binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-containing complex binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in chloride transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in chloride transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in modulation of chemical synaptic transmission	IEA Inferred from Electronic Annotation more info
involved_in modulation of chemical synaptic transmission	ISO Inferred from Sequence Orthology more info
involved_in regulation of presynaptic membrane potential	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of GABA-A receptor complex	IBA Inferred from Biological aspect of Ancestor more info
located_in GABA-ergic synapse	IEA Inferred from Electronic Annotation more info
is_active_in GABA-ergic synapse	ISO Inferred from Sequence Orthology more info
part_of chloride channel complex	IEA Inferred from Electronic Annotation more info
located_in glutamatergic synapse	IEA Inferred from Electronic Annotation more info
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in intracellular vesicle	IEA Inferred from Electronic Annotation more info
is_active_in intracellular vesicle	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in postsynaptic membrane	IEA Inferred from Electronic Annotation more info
located_in presynaptic membrane	IEA Inferred from Electronic Annotation more info
is_active_in presynaptic membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: gamma-aminobutyric acid receptor subunit rho-1

Names: GABA(A) receptor subunit rho-1; GABA(C) receptor; GABAAR subunit rho-1; gamma-aminobutyric acid (GABA) A receptor, rho 1; gamma-aminobutyric acid (GABA) receptor, rho 1; gamma-aminobutyric acid (GABA-A) receptor, subunit rho 1; gamma-aminobutyric acid (GABA-C) receptor, subunit rho 1; gamma-aminobutyric acid A receptor, rho 1; gamma-aminobutyric acid type A receptor rho 1 subunit

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_017291.4 → NP_058987.3 gamma-aminobutyric acid receptor subunit rho-1 precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000005

UniProtKB/Swiss-Prot

P50572

UniProtKB/TrEMBL

A6IIL1, F1LPA8

Related

ENSRNOP00000010172.6, ENSRNOT00000010172.8

Conserved Domains (2) summary

TIGR00860
Location:76 → 479

LIC; Cation transporter family protein

cd19005
Location:97 → 282

LGIC_ECD_GABAAR_rho; extracellular domain of gamma-aminobutyric acid receptor subunit rho