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    DECR1 2,4-dienoyl-CoA reductase 1 [ Homo sapiens (human) ]

    Gene ID: 1666, updated on 10-Dec-2024

    Summary

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    Official Symbol
    DECR1provided by HGNC
    Official Full Name
    2,4-dienoyl-CoA reductase 1provided by HGNC
    Primary source
    HGNC:HGNC:2753
    See related
    Ensembl:ENSG00000104325 MIM:222745; AllianceGenome:HGNC:2753
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    DECR; NADPH; SDR18C1
    Summary
    Enables 2,4-dienoyl-CoA reductase (NADPH) activity; NADPH binding activity; and identical protein binding activity. Involved in fatty acid beta-oxidation. Located in cytosol; mitochondrion; and nucleoplasm. Part of catalytic complex. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in liver (RPKM 86.6), fat (RPKM 60.8) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See DECR1 in Genome Data Viewer
    Location:
    8q21.3
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (90001477..90053633)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (91125148..91177304)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (91013705..91065861)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124901974 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:90913443-90914208 Neighboring gene ReSE screen-validated silencer GRCh37_chr8:90914502-90914800 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19347 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19348 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr8:90959982-90961181 Neighboring gene oxidative stress induced growth inhibitor family member 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27608 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:90996459-90997255 Neighboring gene Sharpr-MPRA regulatory region 13813 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19350 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27609 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27610 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27611 Neighboring gene nibrin Neighboring gene uncharacterized LOC124901976 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr8:91107580-91108779 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:91109970-91110642 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:91110643-91111314 Neighboring gene calbindin 1 Neighboring gene GATA motif-containing MPRA enhancer 124 Neighboring gene CRISPRi-validated cis-regulatory element chr8.2225 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr8:91227356-91227995 Neighboring gene long intergenic non-protein coding RNA 534 Neighboring gene uncharacterized LOC124901975

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. NADPH-dependent beta-oxidation of unsaturated fatty acids with double bonds extending from odd-numbered carbon atoms. Smeland TE, et al. Proc Natl Acad Sci U S A, 1992 Aug 1. PMID 1495956, Free PMC Article
    2. Uric acid induces NADPH oxidase-independent neutrophil extracellular trap formation. Arai Y, et al. Biochem Biophys Res Commun, 2014 Jan 10. PMID 24326071
    3. 2,4-dienoyl-CoA reductase regulates lipid homeostasis in treatment-resistant prostate cancer. Blomme A, et al. Nat Commun, 2020 May 19. PMID 32427840, Free PMC Article
    4. Human DECR1 is an androgen-repressed survival factor that regulates PUFA oxidation to protect prostate tumor cells from ferroptosis. Nassar ZD, et al. Elife, 2020 Jul 20. PMID 32686647, Free PMC Article
    5. Maintenance of luminal NADPH in the endoplasmic reticulum promotes the survival of human neutrophil granulocytes. Kardon T, et al. FEBS Lett, 2008 Jun 11. PMID 18472006

    See all (93) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. DECR1 directly activates HSL to promote lipolysis in cervical cancer cells.
      Title: DECR1 directly activates HSL to promote lipolysis in cervical cancer cells.
    2. Reduced 2,4-dienoyl-CoA reductase 1 is served as an unfavorable biomarker and is related to immune infiltration in cervical cancer.
      Title: Reduced 2,4-dienoyl-CoA reductase 1 is served as an unfavorable biomarker and is related to immune infiltration in cervical cancer.
    3. NADPH Oxidases in the Central Nervous System: Regional and Cellular Localization and the Possible Link to Brain Diseases.
      Title: NADPH Oxidases in the Central Nervous System: Regional and Cellular Localization and the Possible Link to Brain Diseases.
    4. Association of whole mtDNA, an NADPH G11914A variant, and haplogroups with high physical performance in an elite military troop.
      Title: Association of whole mtDNA, an NADPH G11914A variant, and haplogroups with high physical performance in an elite military troop.
    5. Human DECR1 is an androgen-repressed survival factor that regulates PUFA oxidation to protect prostate tumor cells from ferroptosis.
      Title: Human DECR1 is an androgen-repressed survival factor that regulates PUFA oxidation to protect prostate tumor cells from ferroptosis.
    6. 2,4-dienoyl-CoA reductase regulates lipid homeostasis in treatment-resistant prostate cancer.
      Title: 2,4-dienoyl-CoA reductase regulates lipid homeostasis in treatment-resistant prostate cancer.
    7. Our study is the first to demonstrate the novel function of UA in NET formation and may provide insight into the management of patients with hyperuricemia.
      Title: Uric acid induces NADPH oxidase-independent neutrophil extracellular trap formation.
    8. A protein encoded by this locus was found to be differentially expressed in postmortem brains from patients with atypical frontotemporal lobar degeneration.
      Title: Proteomic analysis identifies dysfunction in cellular transport, energy, and protein metabolism in different brain regions of atypical frontotemporal lobar degeneration.
    9. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
      Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
    10. Observational study of gene-disease association. (HuGE Navigator)
      Title: Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.
    Submit: New GeneRIF Correction See all GeneRIFs (16)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Genome-wide association analysis of red blood cell traits in African Americans: the COGENT Network.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables 2,4-dienoyl-CoA reductase (NADPH) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 2,4-dienoyl-CoA reductase (NADPH) activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables NADPH binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in fatty acid beta-oxidation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in fatty acid beta-oxidation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of cold-induced thermogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of catalytic complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		  
    located_in mitochondrial matrix TAS
    Traceable Author Statement
    more info
    		  
    located_in mitochondrion HTP PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		  
    located_in mitochondrion NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleus HDA PubMed 

    General protein information

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    Preferred Names
    2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing], mitochondrial
    Names
    2,4-dienoyl-CoA reductase 1, mitochondrial
    2,4-dienoyl-CoA reductase, mitochondrial
    4-enoyl-CoA reductase
    short chain dehydrogenase/reductase family 18C member 1
    NP_001317504.1
    NP_001350.1
    XP_005250865.1
    XP_011515182.1
    XP_047277365.1
    XP_047277366.1
    XP_054215840.1
    XP_054215841.1
    XP_054215842.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_008042.2 RefSeqGene

      Range
      5001..57157
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001330575.2 → NP_001317504.1  2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing], mitochondrial isoform 2

      Status: REVIEWED

      Source sequence(s)
      AA725334, AC004612, AF069291, AK300069
      Consensus CDS
      CCDS87618.1
      UniProtKB/Swiss-Prot
      Q16698
      Related
      ENSP00000429779.1, ENST00000522161.5

    2. NM_001359.2 → NP_001350.1  2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing], mitochondrial isoform 1 precursor

      See identical proteins and their annotated locations for NP_001350.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AA725334, AC004612, BC105080, CB104585, CR737790, H98841
      Consensus CDS
      CCDS6250.1
      UniProtKB/Swiss-Prot
      B7Z6B8, Q16698, Q2M304, Q93085
      Related
      ENSP00000220764.2, ENST00000220764.7
      Conserved Domains (1) summary
      cd05369
      Location:57 → 303
      TER_DECR_SDR_a; Trans-2-enoyl-CoA reductase (TER) and 2,4-dienoyl-CoA reductase (DECR), atypical (a) SDR

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

      Range
      90001477..90053633
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047421410.1 → XP_047277366.1  2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing], mitochondrial isoform X2

    2. XM_011516880.4 → XP_011515182.1  2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing], mitochondrial isoform X2

      Conserved Domains (2) summary
      cd05369
      Location:48 → 294
      TER_DECR_SDR_a; Trans-2-enoyl-CoA reductase (TER) and 2,4-dienoyl-CoA reductase (DECR), atypical (a) SDR
      PRK07576
      Location:48 → 293
      PRK07576; short chain dehydrogenase; Provisional

    3. XM_005250808.6 → XP_005250865.1  2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing], mitochondrial isoform X3

      Conserved Domains (1) summary
      cd05369
      Location:1 → 211
      TER_DECR_SDR_a; Trans-2-enoyl-CoA reductase (TER) and 2,4-dienoyl-CoA reductase (DECR), atypical (a) SDR

    4. XM_047421409.1 → XP_047277365.1  2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing], mitochondrial isoform X1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060932.1 Alternate T2T-CHM13v2.0

      Range
      91125148..91177304
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054359866.1 → XP_054215841.1  2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing], mitochondrial isoform X2

    2. XM_054359867.1 → XP_054215842.1  2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing], mitochondrial isoform X3

    3. XM_054359865.1 → XP_054215840.1  2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing], mitochondrial isoform X1

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q16698.1 GenPept UniProtKB/Swiss-Prot:Q16698

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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