SPCS3 signal peptidase complex subunit 3 [Homo sapiens (human)] - Gene

Summary

Official Symbol: SPCS3provided by HGNC
Official Full Name: signal peptidase complex subunit 3provided by HGNC
Primary source: HGNC:HGNC:26212
See related: Ensembl:ENSG00000129128 MIM:618854; AllianceGenome:HGNC:26212
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: SPC3; SPC22; SPC23; PRO3567; YLR066W; SPC22/23
Summary: Involved in signal peptide processing and viral protein processing. Located in endoplasmic reticulum. Part of signal peptidase complex. [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in thyroid (RPKM 45.3), appendix (RPKM 34.4) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 4q34.2

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	4	NC_000004.12 (176319966..176332245)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	4	NC_060928.1 (179659012..179671286)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	4	NC_000004.11 (177241117..177253396)

Chromosome 4 - NC_000004.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

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Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Replication interactions

Interaction	Pubs
Knockdown of signal peptidase complex subunit 3 homolog (SPCS3) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells	PubMed

Protein interactions

Protein	Gene	Interaction	Pubs
Envelope transmembrane glycoprotein gp41	env	HIV-1 gp41 is identified to have a physical interaction with signal peptidase complex subunit 3 homolog (SPCS3) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D4S699 (e-PCR)
- UniSTS:95276

D8S2279 (e-PCR)
- UniSTS:473907

RH103378 (e-PCR)
- UniSTS:97705

SHGC-67361 (e-PCR)
- UniSTS:53946

D4S3217 (e-PCR)
- UniSTS:48082

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in protein targeting to ER	IBA Inferred from Biological aspect of Ancestor more info
involved_in proteolysis	IDA Inferred from Direct Assay more info	PubMed
involved_in signal peptide processing	IBA Inferred from Biological aspect of Ancestor more info
involved_in signal peptide processing	IDA Inferred from Direct Assay more info	PubMed
involved_in viral protein processing	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	IDA Inferred from Direct Assay more info
located_in endoplasmic reticulum membrane	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum membrane	TAS Traceable Author Statement more info
part_of signal peptidase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of signal peptidase complex	IPI Inferred from Physical Interaction more info	PubMed

General protein information

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Preferred Names: signal peptidase complex subunit 3

Names: SPase 22 kDa subunit; SPase 22/23 kDa subunit; microsomal signal peptidase 22/23 kDa subunit; microsomal signal peptidase 23 kDa subunit; signal peptidase complex subunit 3 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.