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    SAPCD2 suppressor APC domain containing 2 [ Homo sapiens (human) ]

    Gene ID: 89958, updated on 10-Dec-2024

    Summary

    Official Symbol
    SAPCD2provided by HGNC
    Official Full Name
    suppressor APC domain containing 2provided by HGNC
    Primary source
    HGNC:HGNC:28055
    See related
    Ensembl:ENSG00000186193 MIM:612057; AllianceGenome:HGNC:28055
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    p42.3; C9orf140
    Summary
    Involved in negative regulation of protein localization to cell cortex and positive regulation of cell population proliferation. Located in several cellular components, including apical cortex; apical junction complex; and nuclear lumen. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in brain (RPKM 4.5), colon (RPKM 2.8) and 17 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See SAPCD2 in Genome Data Viewer
    Location:
    9q34.3
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (137062127..137070557, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (149298084..149306470, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (139956579..139965009, complement)

    Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene neural proliferation, differentiation and control 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:139940694-139941363 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:139943096-139943624 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:139943625-139944153 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20567 Neighboring gene ectonucleoside triphosphate diphosphohydrolase 2 Neighboring gene uncharacterized LOC105376327 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20568 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20569 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:139958261-139959038 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:139962228-139963208 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20572 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20571 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20573 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:139965171-139966150 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:139968734-139969347 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20574 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20575 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20576 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20577 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:139972693-139973571 Neighboring gene UDP-N-acetylglucosamine pyrophosphorylase 1 like 1 Neighboring gene ReSE screen-validated silencer GRCh37_chr9:139977971-139978205 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20578 Neighboring gene MAN1B1 divergent transcript

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in establishment of mitotic spindle orientation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of protein localization to cell cortex IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of cell population proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of establishment of planar polarity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in symmetric cell division ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in apical cortex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in apical junction complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in apical plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in bicellular tight junction IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     

    General protein information

    Preferred Names
    suppressor APC domain-containing protein 2
    Names
    2010317E24Rik
    TS/MDEP
    protein C9orf140
    tumor specificity and mitosis phase-dependent expression protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_178448.4NP_848543.2  suppressor APC domain-containing protein 2

      See identical proteins and their annotated locations for NP_848543.2

      Status: VALIDATED

      Source sequence(s)
      BC042162, BC048267, BX332104
      Consensus CDS
      CCDS7027.2
      UniProtKB/Swiss-Prot
      Q86UD0
      Related
      ENSP00000386348.3, ENST00000409687.5
      Conserved Domains (1) summary
      pfam11414
      Location:225306
      Suppressor_APC; Adenomatous polyposis coli tumour suppressor protein

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

      Range
      137062127..137070557 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011519180.4XP_011517482.1  suppressor APC domain-containing protein 2 isoform X1

      Conserved Domains (1) summary
      pfam11414
      Location:255336
      Suppressor_APC; Adenomatous polyposis coli tumour suppressor protein

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060933.1 Alternate T2T-CHM13v2.0

      Range
      149298084..149306470 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)