dus3l.L dihydrouridine synthase 3-like L homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: dus3l.L
Official Full Name: dihydrouridine synthase 3-like L homeolog
Primary source: Xenbase:XB-GENE-943243
Locus tag: XELAEV_18030846mg
See related: EnsemblRapid:ENSXLAG00005032335 AllianceGenome:Xenbase:XB-GENE-943243
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: dus3l
Summary: Predicted to enable tRNA-dihydrouridine47 synthase activity. Predicted to act upstream of or within regulation of translation and tRNA dihydrouridine synthesis. Orthologous to human DUS3L (dihydrouridine synthase 3 like). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

Location:: chromosome: 6L

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	6L	NC_054381.1 (30650383..30663435, complement)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	6L	NC_030734.1 (28165587..28178673, complement)

Chromosome 6L - NC_054381.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables flavin adenine dinucleotide binding	IEA Inferred from Electronic Annotation more info
enables mRNA dihydrouridine synthase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables tRNA dihydrouridine synthase activity	IEA Inferred from Electronic Annotation more info
enables tRNA-dihydrouridine47 synthase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within mRNA processing	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of translation	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within tRNA dihydrouridine synthesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within tRNA dihydrouridine synthesis	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within tRNA processing	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: tRNA-dihydrouridine(47) synthase [NAD(P)(+)]-like

Names: mRNA-dihydrouridine synthase DUS3L; tRNA-dihydrouridine synthase 3-like

NP_001079662.1

EC 1.3.1.89

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001086193.1 → NP_001079662.1 tRNA-dihydrouridine(47) synthase [NAD(P)(+)]-like

See identical proteins and their annotated locations for NP_001079662.1

Status: PROVISIONAL

Source sequence(s)

BC046730

UniProtKB/Swiss-Prot

Q7ZWS1

UniProtKB/TrEMBL

A0A974HF42

Related

ENSXLAP00005097072.1, ENSXLAT00005098854.1

Conserved Domains (2) summary

COG0042
Location:291 → 566

DusA; tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]

cd02801
Location:296 → 528

DUS_like_FMN; Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also ...

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

NC_054381.1 Reference Xenopus_laevis_v10.1 Primary Assembly

Range

30650383..30663435 complement

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GenBank, FASTA, Sequence Viewer (Graphics)