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    Dctn2 dynactin 2 [ Mus musculus (house mouse) ]

    Gene ID: 69654, updated on 13-Jan-2025

    Summary

    Official Symbol
    Dctn2provided by MGI
    Official Full Name
    dynactin 2provided by MGI
    Primary source
    MGI:MGI:107733
    See related
    Ensembl:ENSMUSG00000025410 AllianceGenome:MGI:107733
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    p50; RBP50; DCTN-50; GMP23-48K; 2310042E05Rik; C130077D06Rik
    Summary
    Predicted to enable identical protein binding activity; protein kinase binding activity; and spectrin binding activity. Acts upstream of or within melanosome transport. Located in growth cone. Is expressed in several structures, including adipose tissue; alimentary system; hemolymphoid system; nervous system; and reproductive system. Orthologous to human DCTN2 (dynactin subunit 2). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Ubiquitous expression in testis adult (RPKM 150.2), adrenal adult (RPKM 99.3) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Dctn2 in Genome Data Viewer
    Location:
    10 D3; 10 74.5 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (127102131..127117828)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (127266262..127281959)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA F420014N23 gene Neighboring gene phosphatidylinositol-5-phosphate 4-kinase, type II, gamma Neighboring gene STARR-seq mESC enhancer starr_28215 Neighboring gene kinesin family member 5A Neighboring gene STARR-positive B cell enhancer ABC_E9810 Neighboring gene predicted gene, 40800 Neighboring gene STARR-positive B cell enhancer ABC_E10652 Neighboring gene STARR-positive B cell enhancer ABC_E1410 Neighboring gene STARR-positive B cell enhancer ABC_E6939 Neighboring gene methyl-CpG binding domain protein 6 Neighboring gene DNA-damage inducible transcript 3 Neighboring gene methionine-tRNA synthetase 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:126748829-126749012 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (2) 

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables identical protein binding  
    enables identical protein binding  
    enables protein binding PubMed 
    enables protein kinase binding  
    enables protein kinase binding  
    enables spectrin binding PubMed 
    Component Evidence Code Pubs
    is_active_in centrosome  
    located_in centrosome  
    located_in centrosome  
    is_active_in cytoplasm  
    located_in cytosol  
    located_in cytosol  
    part_of dynactin complex  
    part_of dynactin complex  
    part_of dynactin complex  
    part_of dynein complex  
    located_in growth cone PubMed 
    located_in kinetochore  
    located_in kinetochore  
    located_in membrane  
    located_in microtubule  
    located_in vesicle  
    located_in vesicle  

    General protein information

    Preferred Names
    dynactin subunit 2
    Names
    50 kDa dynein-associated polypeptide
    dynactin complex 50 kDa subunit
    growth cone membrane protein 23-48K
    p50 dynamitin

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001190453.1NP_001177382.1  dynactin subunit 2 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an in-frame exon in the 5' coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
      Source sequence(s)
      AC144852
      Conserved Domains (1) summary
      pfam04912
      Location:16402
      Dynamitin; Dynamitin
    2. NM_001190454.1NP_001177383.1  dynactin subunit 2 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC144852
      Conserved Domains (1) summary
      pfam04912
      Location:16405
      Dynamitin; Dynamitin
    3. NM_027151.2NP_081427.1  dynactin subunit 2 isoform 3

      See identical proteins and their annotated locations for NP_081427.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks two in-frame exons in the 5' coding region, compared to variant 1. This results in a shorter protein (isoform 3), compared to isoform 1.
      Source sequence(s)
      AC144852, AK144464
      Consensus CDS
      CCDS24234.1
      UniProtKB/Swiss-Prot
      Q99KJ8
      UniProtKB/TrEMBL
      Q3TPZ5
      Related
      ENSMUSP00000026479.10, ENSMUST00000026479.11
      Conserved Domains (1) summary
      pfam04912
      Location:16400
      Dynamitin; Dynamitin

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      127102131..127117828
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006514055.4XP_006514118.1  dynactin subunit 2 isoform X1

      Conserved Domains (1) summary
      pfam04912
      Location:16401
      Dynamitin
    2. XM_036155985.1XP_036011878.1  dynactin subunit 2 isoform X2

      Conserved Domains (1) summary
      pfam04912
      Location:2313
      Dynamitin
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