Rad51b RAD51 paralog B [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Rad51bprovided by MGI
Official Full Name: RAD51 paralog Bprovided by MGI
Primary source: MGI:MGI:1099436
See related: Ensembl:ENSMUSG00000059060 AllianceGenome:MGI:1099436
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: R51H2; mREC2; Rad51l1
Summary: Predicted to enable ATP-dependent activity, acting on DNA; double-stranded DNA binding activity; and single-stranded DNA binding activity. Predicted to contribute to four-way junction DNA binding activity. Acts upstream of or within blastocyst growth; positive regulation of cell population proliferation; and somite development. Predicted to be part of Rad51B-Rad51C-Rad51D-XRCC2 complex. Predicted to be active in replication fork. Is expressed in cerebral cortex; cranial ganglion; dorsal root ganglion; neural retina; and ventral grey horn. Orthologous to human RAD51B (RAD51 paralog B). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Low expression observed in reference dataset See more
Orthologs: human all
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Genomic context

Location:: 12 C3; 12 35.51 cM

Exon count:: 22

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	12	NC_000078.7 (79344032..79895034)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	12	NC_000078.6 (79297282..79848260)

Chromosome 12 - NC_000078.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A truncating variant of RAD51B associated with primary ovarian insufficiency provides insights into its meiotic and somatic functions.
Title: A truncating variant of RAD51B associated with primary ovarian insufficiency provides insights into its meiotic and somatic functions.
Our study shows that a miR-590/Acvr2a/Rad51b signaling axis ensures the stabilization of mESCs by balancing DNA damage repair and rapid proliferation during self-renewal.
Title: A miR-590/Acvr2a/Rad51b axis regulates DNA damage repair during mESC proliferation.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:236882

D12Dcr7 (e-PCR), detects polymorphism
- UniSTS:507490

RH69431 (e-PCR)
- UniSTS:64935

D12Mit156 (e-PCR), detects polymorphism
- UniSTS:116399

RH126033 (e-PCR)
- UniSTS:162745

AI553500 (e-PCR)
- UniSTS:180411

U92068 (e-PCR)
- UniSTS:160221

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables ATP-dependent DNA damage sensor activity	IEA Inferred from Electronic Annotation more info
enables ATP-dependent activity, acting on DNA	IBA Inferred from Biological aspect of Ancestor more info
enables ATP-dependent activity, acting on DNA	ISO Inferred from Sequence Orthology more info
enables double-stranded DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables double-stranded DNA binding	ISO Inferred from Sequence Orthology more info
enables double-stranded DNA binding	ISS Inferred from Sequence or Structural Similarity more info
contributes_to four-way junction DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables four-way junction DNA binding	IEA Inferred from Electronic Annotation more info
contributes_to four-way junction DNA binding	ISO Inferred from Sequence Orthology more info
enables single-stranded DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables single-stranded DNA binding	ISO Inferred from Sequence Orthology more info
enables single-stranded DNA binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within blastocyst growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in double-strand break repair via homologous recombination	IBA Inferred from Biological aspect of Ancestor more info
involved_in double-strand break repair via homologous recombination	ISO Inferred from Sequence Orthology more info
involved_in double-strand break repair via homologous recombination	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within in utero embryonic development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within in utero embryonic development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of G2/M transition of mitotic cell cycle	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of G2/M transition of mitotic cell cycle	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within positive regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within somite development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of Rad51B-Rad51C-Rad51D-XRCC2 complex	ISO Inferred from Sequence Orthology more info
part_of Rad51B-Rad51C-Rad51D-XRCC2 complex	ISS Inferred from Sequence or Structural Similarity more info
is_active_in replication fork	IBA Inferred from Biological aspect of Ancestor more info
located_in replication fork	ISO Inferred from Sequence Orthology more info
located_in replication fork	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: DNA repair protein RAD51 homolog 2

Names: RAD51 homolog B; RAD51-like protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001252562.1 → NP_001239491.1 DNA repair protein RAD51 homolog 2 isoform 2

See identical proteins and their annotated locations for NP_001239491.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR and lacks several exons but includes an alternate 3_ terminal exon, compared to variant 1. The resulting isoform (2) is shorter and has a distinct C-terminus, compared to isoform 1.

Source sequence(s)

AK015771

Consensus CDS

CCDS56845.1

UniProtKB/Swiss-Prot

O35719

Related

ENSMUSP00000078490.6, ENSMUST00000079533.12

Conserved Domains (1) summary

cd01123
Location:83 → 253

Rad51_DMC1_radA; Rad51_DMC1_radA,B. This group of recombinases includes the eukaryotic proteins RAD51, RAD55/57 and the meiosis-specific protein DMC1, and the archaeal proteins radA and radB. They are closely related to the bacterial RecA group. Rad51 proteins catalyze a ...
NM_001423114.1 → NP_001410043.1 DNA repair protein RAD51 homolog 2 isoform 1

Status: VALIDATED

Source sequence(s)

AC124250, AC158527

UniProtKB/Swiss-Prot

O35719, Q8BSH6, Q9D555
NM_001423115.1 → NP_001410044.1 DNA repair protein RAD51 homolog 2 isoform 1

Status: VALIDATED

Source sequence(s)

AC124250, AC158527

UniProtKB/Swiss-Prot

O35719, Q8BSH6, Q9D555

Related

ENSMUSP00000152105.2, ENSMUST00000218039.3
NM_009014.3 → NP_033040.2 DNA repair protein RAD51 homolog 2 isoform 1

See identical proteins and their annotated locations for NP_033040.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longer isoform (1).

Source sequence(s)

AK032913

Consensus CDS

CCDS88360.1

UniProtKB/Swiss-Prot

O35719, Q8BSH6, Q9D555

Related

ENSMUSP00000128357.3, ENSMUST00000171210.3

Conserved Domains (1) summary

cd19493
Location:91 → 327

Rad51B; RAD51B recombinase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000078.7 Reference GRCm39 C57BL/6J

Range

79344032..79895034

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036157266.1 → XP_036013159.1 DNA repair protein RAD51 homolog 2 isoform X5

Conserved Domains (1) summary

cd19493
Location:91 → 327

Rad51B; RAD51B recombinase
XM_036157265.1 → XP_036013158.1 DNA repair protein RAD51 homolog 2 isoform X5

Conserved Domains (1) summary

cd19493
Location:91 → 327

Rad51B; RAD51B recombinase
XM_036157264.1 → XP_036013157.1 DNA repair protein RAD51 homolog 2 isoform X5

Conserved Domains (1) summary

cd19493
Location:91 → 327

Rad51B; RAD51B recombinase
XM_036157269.1 → XP_036013162.1 DNA repair protein RAD51 homolog 2 isoform X6

UniProtKB/Swiss-Prot

O35719, Q8BSH6, Q9D555

Conserved Domains (1) summary

cd19493
Location:91 → 327

Rad51B; RAD51B recombinase
XM_011244039.3 → XP_011242341.1 DNA repair protein RAD51 homolog 2 isoform X7

Conserved Domains (1) summary

cd01123
Location:94 → 266

Rad51_DMC1_radA; B. This group of recombinases includes the eukaryotic proteins RAD51, RAD55/57 and the meiosis-specific protein DMC1, and the archaeal proteins radA and radB. They are closely related to the bacterial RecA group. Rad51 proteins catalyze a similiar ...
XM_030246621.2 → XP_030102481.1 DNA repair protein RAD51 homolog 2 isoform X1

Conserved Domains (1) summary

cd01123
Location:94 → 369

Rad51_DMC1_radA; B. This group of recombinases includes the eukaryotic proteins RAD51, RAD55/57 and the meiosis-specific protein DMC1, and the archaeal proteins radA and radB. They are closely related to the bacterial RecA group. Rad51 proteins catalyze a similiar ...
XM_017315003.2 → XP_017170492.1 DNA repair protein RAD51 homolog 2 isoform X2

Conserved Domains (1) summary

cd01123
Location:94 → 369

Rad51_DMC1_radA; B. This group of recombinases includes the eukaryotic proteins RAD51, RAD55/57 and the meiosis-specific protein DMC1, and the archaeal proteins radA and radB. They are closely related to the bacterial RecA group. Rad51 proteins catalyze a similiar ...
XM_006515624.3 → XP_006515687.1 DNA repair protein RAD51 homolog 2 isoform X3

Conserved Domains (1) summary

cd01123
Location:94 → 354

Rad51_DMC1_radA; B. This group of recombinases includes the eukaryotic proteins RAD51, RAD55/57 and the meiosis-specific protein DMC1, and the archaeal proteins radA and radB. They are closely related to the bacterial RecA group. Rad51 proteins catalyze a similiar ...
XM_006515625.3 → XP_006515688.1 DNA repair protein RAD51 homolog 2 isoform X4

Conserved Domains (1) summary

cd01123
Location:94 → 354

Rad51_DMC1_radA; B. This group of recombinases includes the eukaryotic proteins RAD51, RAD55/57 and the meiosis-specific protein DMC1, and the archaeal proteins radA and radB. They are closely related to the bacterial RecA group. Rad51 proteins catalyze a similiar ...