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    DENND4C DENN domain containing 4C [ Homo sapiens (human) ]

    Gene ID: 55667, updated on 10-Dec-2024

    Summary

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    Official Symbol
    DENND4Cprovided by HGNC
    Official Full Name
    DENN domain containing 4Cprovided by HGNC
    Primary source
    HGNC:HGNC:26079
    See related
    Ensembl:ENSG00000137145 AllianceGenome:HGNC:26079
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    C9orf55; C9orf55B; RAB10GEF; bA513M16.3
    Summary
    Enables guanyl-nucleotide exchange factor activity. Predicted to be involved in cellular response to insulin stimulus; protein localization to plasma membrane; and regulation of Rab protein signal transduction. Located in Golgi apparatus and cytosol. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in duodenum (RPKM 11.5), skin (RPKM 11.0) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See DENND4C in Genome Data Viewer
    Location:
    9p22.1
    Exon count:
    36
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (19230513..19374281)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (19243303..19387084)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (19230511..19374279)

    Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 12241 Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:19126736-19127246 Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:19127247-19127756 Neighboring gene perilipin 2 Neighboring gene CRISPRi-validated cis-regulatory element chr9.246 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28219 Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:19186502-19187002 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:19202444-19202962 Neighboring gene ribosomal protein S6 pseudogene 10 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28220 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19791 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:19230483-19230989 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:19230990-19231495 Neighboring gene ReSE screen-validated silencer GRCh37_chr9:19233697-19233870 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:19250753-19251617 Neighboring gene uncharacterized LOC124902350 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr9:19379549-19380748 Neighboring gene NADH:ubiquinone oxidoreductase subunit A5 pseudogene 3 Neighboring gene ribosomal protein S6

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Circ DENND4C inhibits pyroptosis and alleviates ischemia-reperfusion acute kidney injury by exosomes secreted from human urine-derived stem cells. Yang B, et al. Chem Biol Interact, 2024 Mar 1. PMID 38412628
    2. Knockdown of circDENND4C inhibits glycolysis, migration and invasion by up-regulating miR-200b/c in breast cancer under hypoxia. Ren S, et al. J Exp Clin Cancer Res, 2019 Sep 5. PMID 31488193, Free PMC Article
    3. Molecular cloning, structural analysis, and expression of a human IRLB, MYC promoter-binding protein: new DENN domain-containing protein family emerges. Semova N, et al. Genomics, 2003 Sep. PMID 12906859
    4. circDENND4C, a novel serum marker for epithelial ovarian cancer, acts as a tumor suppressor by downregulating miR-200b/c. Liu S, et al. Ann Med, 2023 Dec. PMID 36896567, Free PMC Article
    5. Circular RNA circDENND4C facilitates proliferation, migration and glycolysis of colorectal cancer cells through miR-760/GLUT1 axis. Zhang ZJ, et al. Eur Rev Med Pharmacol Sci, 2020 Mar. PMID 32196590

    See all (54) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Circ DENND4C inhibits pyroptosis and alleviates ischemia-reperfusion acute kidney injury by exosomes secreted from human urine-derived stem cells.
      Title: Circ DENND4C inhibits pyroptosis and alleviates ischemia-reperfusion acute kidney injury by exosomes secreted from human urine-derived stem cells.
    2. circDENND4C, a novel serum marker for epithelial ovarian cancer, acts as a tumor suppressor by downregulating miR-200b/c.
      Title: circDENND4C, a novel serum marker for epithelial ovarian cancer, acts as a tumor suppressor by downregulating miR-200b/c.
    3. Circular RNA circDENND4C facilitates proliferation, migration and glycolysis of colorectal cancer cells through miR-760/GLUT1 axis.
      Title: Circular RNA circDENND4C facilitates proliferation, migration and glycolysis of colorectal cancer cells through miR-760/GLUT1 axis.
    4. circDENND4C silence suppresses glycolysis, migration and invasion in breast cancer cells under hypoxia by increasing miR-200b and miR-200c.
      Title: Knockdown of circDENND4C inhibits glycolysis, migration and invasion by up-regulating miR-200b/c in breast cancer under hypoxia.
    5. Insulin-stimulated GLUT4 protein translocation in adipocytes requires the Rab10 guanine nucleotide exchange factor Dennd4C
      Title: Insulin-stimulated GLUT4 protein translocation in adipocytes requires the Rab10 guanine nucleotide exchange factor Dennd4C.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ20686, DKFZp686I09113

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables guanyl-nucleotide exchange factor activity TAS
    Traceable Author Statement
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to insulin stimulus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein localization to plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of Rab protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		  
    is_active_in cytoplasmic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasmic vesicle membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		  
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in insulin-responsive compartment ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in intracellular membrane-bounded organelle IDA
    Inferred from Direct Assay
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of retromer complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    DENN domain-containing protein 4C
    Names
    DENN/MADD domain containing 4A pseudogene
    DENN/MADD domain containing 4C

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001330640.2 → NP_001317569.1  DENN domain-containing protein 4C isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL161909, AL391834
      Consensus CDS
      CCDS83349.1
      UniProtKB/Swiss-Prot
      Q5VZ89
      Related
      ENSP00000473469.1, ENST00000434457.7
      Conserved Domains (4) summary
      smart00801
      Location:559 → 632
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00800
      Location:192 → 276
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
      sd00004
      Location:820 → 849
      PPR; PPR repeat [structural motif]
      pfam02141
      Location:309 → 492
      DENN; DENN (AEX-3) domain

    2. NM_001386026.2 → NP_001372955.1  DENN domain-containing protein 4C isoform 5

      Status: VALIDATED

      Source sequence(s)
      AL161909, AL391834
      Conserved Domains (4) summary
      smart00801
      Location:559 → 632
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00800
      Location:192 → 276
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
      sd00004
      Location:820 → 849
      PPR; PPR repeat [structural motif]
      pfam02141
      Location:309 → 492
      DENN; DENN (AEX-3) domain

    3. NM_001386030.1 → NP_001372959.1  DENN domain-containing protein 4C isoform 6

      Status: VALIDATED

      Source sequence(s)
      AL161909, AL391834
      Conserved Domains (4) summary
      smart00801
      Location:524 → 597
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00800
      Location:192 → 276
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
      sd00004
      Location:785 → 814
      PPR; PPR repeat [structural motif]
      pfam02141
      Location:309 → 457
      DENN; DENN (AEX-3) domain

    4. NM_001386031.1 → NP_001372960.1  DENN domain-containing protein 4C isoform 7

      Status: VALIDATED

      Source sequence(s)
      AL161909, AL391834
      Conserved Domains (1) summary
      sd00004
      Location:255 → 284
      PPR; PPR repeat [structural motif]

    5. NM_001386032.1 → NP_001372961.1  DENN domain-containing protein 4C isoform 4

      Status: VALIDATED

      Source sequence(s)
      AL161909, AL391834
      Conserved Domains (2) summary
      smart00801
      Location:57 → 130
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      sd00004
      Location:318 → 347
      PPR; PPR repeat [structural motif]

    6. NM_001386034.1 → NP_001372963.1  DENN domain-containing protein 4C isoform 4

      Status: VALIDATED

      Source sequence(s)
      AL161909, AL391834
      Conserved Domains (2) summary
      smart00801
      Location:57 → 130
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      sd00004
      Location:318 → 347
      PPR; PPR repeat [structural motif]

    7. NM_001386035.1 → NP_001372964.1  DENN domain-containing protein 4C isoform 8

      Status: VALIDATED

      Source sequence(s)
      AL161909, AL391834
      Conserved Domains (3) summary
      smart00801
      Location:207 → 280
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      sd00004
      Location:468 → 497
      PPR; PPR repeat [structural motif]
      pfam02141
      Location:1 → 140
      DENN; DENN (AEX-3) domain

    8. NM_001386036.1 → NP_001372965.1  DENN domain-containing protein 4C isoform 9

      Status: VALIDATED

      Source sequence(s)
      AL161909, AL391834
      Conserved Domains (2) summary
      smart00801
      Location:165 → 238
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      sd00004
      Location:426 → 455
      PPR; PPR repeat [structural motif]

    9. NM_001386037.1 → NP_001372966.1  DENN domain-containing protein 4C isoform 10

      Status: VALIDATED

      Source sequence(s)
      AL161909, AL391834
      Conserved Domains (4) summary
      smart00801
      Location:559 → 632
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00800
      Location:192 → 276
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
      sd00004
      Location:752 → 780
      PPR; PPR repeat [structural motif]
      pfam02141
      Location:309 → 492
      DENN; DENN (AEX-3) domain

    10. NM_001386038.1 → NP_001372967.1  DENN domain-containing protein 4C isoform 11

      Status: VALIDATED

      Source sequence(s)
      AL161909, AL391834
      Conserved Domains (4) summary
      smart00801
      Location:559 → 632
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00800
      Location:192 → 276
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
      sd00004
      Location:820 → 849
      PPR; PPR repeat [structural motif]
      pfam02141
      Location:309 → 492
      DENN; DENN (AEX-3) domain

    11. NM_001386039.1 → NP_001372968.1  DENN domain-containing protein 4C isoform 12

      Status: VALIDATED

      Source sequence(s)
      AL161909, AL391834
      Conserved Domains (2) summary
      smart00801
      Location:57 → 130
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      sd00004
      Location:318 → 347
      PPR; PPR repeat [structural motif]

    12. NM_001386040.1 → NP_001372969.1  DENN domain-containing protein 4C isoform 13

      Status: VALIDATED

      Source sequence(s)
      AL161909, AL391834
      Conserved Domains (4) summary
      smart00801
      Location:559 → 632
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00800
      Location:192 → 276
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
      sd00004
      Location:820 → 849
      PPR; PPR repeat [structural motif]
      pfam02141
      Location:309 → 492
      DENN; DENN (AEX-3) domain

    13. NM_001386041.1 → NP_001372970.1  DENN domain-containing protein 4C isoform 14

      Status: VALIDATED

      Source sequence(s)
      AL161909, AL391834
      Conserved Domains (4) summary
      smart00801
      Location:559 → 632
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00800
      Location:192 → 276
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
      sd00004
      Location:752 → 780
      PPR; PPR repeat [structural motif]
      pfam02141
      Location:309 → 492
      DENN; DENN (AEX-3) domain

    14. NM_001386042.1 → NP_001372971.1  DENN domain-containing protein 4C isoform 15

      Status: VALIDATED

      Source sequence(s)
      AL161909, AL391834
      Conserved Domains (4) summary
      smart00801
      Location:559 → 632
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00800
      Location:192 → 276
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
      sd00004
      Location:820 → 849
      PPR; PPR repeat [structural motif]
      pfam02141
      Location:309 → 492
      DENN; DENN (AEX-3) domain

    15. NM_001386043.1 → NP_001372972.1  DENN domain-containing protein 4C isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL161909, AL391834
      Conserved Domains (4) summary
      smart00801
      Location:323 → 396
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      sd00004
      Location:584 → 613
      PPR; PPR repeat [structural motif]
      pfam02141
      Location:73 → 256
      DENN; DENN (AEX-3) domain
      cl04085
      Location:1 → 40
      uDENN; uDENN domain

    16. NM_001386044.1 → NP_001372973.1  DENN domain-containing protein 4C isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL161909, AL391834
      Conserved Domains (4) summary
      smart00801
      Location:323 → 396
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      sd00004
      Location:584 → 613
      PPR; PPR repeat [structural motif]
      pfam02141
      Location:73 → 256
      DENN; DENN (AEX-3) domain
      cl04085
      Location:1 → 40
      uDENN; uDENN domain

    17. NM_001386045.1 → NP_001372974.1  DENN domain-containing protein 4C isoform 16

      Status: VALIDATED

      Source sequence(s)
      AL161909, AL391834
      Conserved Domains (4) summary
      smart00801
      Location:559 → 632
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00800
      Location:192 → 276
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
      sd00004
      Location:820 → 849
      PPR; PPR repeat [structural motif]
      pfam02141
      Location:309 → 492
      DENN; DENN (AEX-3) domain

    18. NM_001386046.1 → NP_001372975.1  DENN domain-containing protein 4C isoform 17

      Status: VALIDATED

      Source sequence(s)
      AL161909, AL391834
      Conserved Domains (4) summary
      smart00801
      Location:559 → 632
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00800
      Location:192 → 276
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
      sd00004
      Location:752 → 780
      PPR; PPR repeat [structural motif]
      pfam02141
      Location:309 → 492
      DENN; DENN (AEX-3) domain

    19. NM_001386047.1 → NP_001372976.1  DENN domain-containing protein 4C isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL161909, AL391834
      Consensus CDS
      CCDS83349.1
      Conserved Domains (4) summary
      smart00801
      Location:559 → 632
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00800
      Location:192 → 276
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
      sd00004
      Location:820 → 849
      PPR; PPR repeat [structural motif]
      pfam02141
      Location:309 → 492
      DENN; DENN (AEX-3) domain

    20. NM_001386048.1 → NP_001372977.1  DENN domain-containing protein 4C isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL161909, AL391834
      Conserved Domains (4) summary
      smart00801
      Location:323 → 396
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      sd00004
      Location:584 → 613
      PPR; PPR repeat [structural motif]
      pfam02141
      Location:73 → 256
      DENN; DENN (AEX-3) domain
      cl04085
      Location:1 → 40
      uDENN; uDENN domain

    21. NM_017925.7 → NP_060395.5  DENN domain-containing protein 4C isoform 1

      See identical proteins and their annotated locations for NP_060395.5

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes isoform 1.
      Source sequence(s)
      AK125842, AL161909, AL391834, AW271839, CN427691, DA517991, DV080472, HY106197
      Consensus CDS
      CCDS6491.3
      UniProtKB/Swiss-Prot
      A2A3R1, A2A3R2, A2A3R3, A2A3R9, Q5VZ89, Q6AI48, Q6ZUB3, Q8NCY7, Q9H6N4, Q9NUT1, Q9NWA5, Q9NWT3, R4GN35, R4GNB2
      Related
      ENSP00000473565.1, ENST00000602925.5
      Conserved Domains (4) summary
      smart00801
      Location:559 → 632
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00800
      Location:192 → 276
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
      sd00004
      Location:820 → 849
      PPR; PPR repeat [structural motif]
      pfam02141
      Location:310 → 492
      DENN; DENN (AEX-3) domain

    RNA

    1. NR_073201.4 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks two alternate exons, and includes two alternate exons, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AL161909, AL391834, AW271839, BC144485, DA517991, DV080472, HY106197

    2. NR_169842.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL161909, AL391834

    3. NR_169843.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL161909, AL391834

    4. NR_169844.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL161909, AL391834

    5. NR_169845.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL161909, AL391834

    6. NR_169846.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL161909, AL391834

    7. NR_169847.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL161909, AL391834

    8. NR_169848.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL161909, AL391834

    9. NR_169849.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL161909, AL391834

    10. NR_169850.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL161909, AL391834

    11. NR_169851.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL161909, AL391834

    12. NR_169852.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL161909, AL391834

    13. NR_169853.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL161909, AL391834

    14. NR_169854.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL161909, AL391834

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

      Range
      19230513..19374281
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047423585.1 → XP_047279541.1  DENN domain-containing protein 4C isoform X2

    2. XM_047423584.1 → XP_047279540.1  DENN domain-containing protein 4C isoform X1

      UniProtKB/Swiss-Prot
      A2A3R1, A2A3R2, A2A3R3, A2A3R9, Q5VZ89, Q6AI48, Q6ZUB3, Q8NCY7, Q9H6N4, Q9NUT1, Q9NWA5, Q9NWT3, R4GN35, R4GNB2

    3. XM_047423586.1 → XP_047279542.1  DENN domain-containing protein 4C isoform X3

    4. XM_011517959.4 → XP_011516261.1  DENN domain-containing protein 4C isoform X4

      Conserved Domains (5) summary
      smart00801
      Location:559 → 632
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00800
      Location:192 → 276
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
      sd00004
      Location:820 → 849
      PPR; PPR repeat [structural motif]
      pfam02141
      Location:309 → 492
      DENN; DENN (AEX-3) domain
      pfam13041
      Location:819 → 858
      PPR_2; PPR repeat family

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060933.1 Alternate T2T-CHM13v2.0

      Range
      19243303..19387084
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054363271.1 → XP_054219246.1  DENN domain-containing protein 4C isoform X2

    2. XM_054363270.1 → XP_054219245.1  DENN domain-containing protein 4C isoform X1

      UniProtKB/Swiss-Prot
      A2A3R1, A2A3R2, A2A3R3, A2A3R9, Q5VZ89, Q6AI48, Q6ZUB3, Q8NCY7, Q9H6N4, Q9NUT1, Q9NWA5, Q9NWT3, R4GN35, R4GNB2

    3. XM_054363272.1 → XP_054219247.1  DENN domain-containing protein 4C isoform X3

    4. XM_054363273.1 → XP_054219248.1  DENN domain-containing protein 4C isoform X4

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NG_023879.1: Suppressed sequence

      Description
      NG_023879.1: This RefSeq was suppressed because review of this locus determined that it is not a non-transcribed pseudogene; it represents a region of the DENND4C (GeneID: 55667) gene.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5VZ89.3 GenPept UniProtKB/Swiss-Prot:Q5VZ89

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