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    Cyp4a31 cytochrome P450, family 4, subfamily a, polypeptide 31 [ Mus musculus (house mouse) ]

    Gene ID: 666168, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Cyp4a31provided by MGI
    Official Full Name
    cytochrome P450, family 4, subfamily a, polypeptide 31provided by MGI
    Primary source
    MGI:MGI:3028580
    See related
    Ensembl:ENSMUSG00000028712 AllianceGenome:MGI:3028580
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to enable monooxygenase activity. Predicted to be involved in carboxylic acid metabolic process; kidney development; and positive regulation of icosanoid secretion. Predicted to be located in apical plasma membrane and cytoplasm. Predicted to be active in intracellular membrane-bounded organelle. Human ortholog(s) of this gene implicated in hypertension. Orthologous to human CYP4A11 (cytochrome P450 family 4 subfamily A member 11). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in kidney adult (RPKM 73.0), liver adult (RPKM 25.6) and 1 other tissue See more
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    Genomic context

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    See Cyp4a31 in Genome Data Viewer
    Location:
    4 D1; 4 53.06 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (115420824..115436212)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (115563627..115579015)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_11120 Neighboring gene cytochrome P450, family 4, subfamily a, polypeptide 10 Neighboring gene cytochrome P450, family 4, subfamily b, polypeptide 1, pseudogene 1 Neighboring gene STARR-seq mESC enhancer starr_11121 Neighboring gene cytochrome P450, family 4, subfamily b, polypeptide 1, pseudogene 2 Neighboring gene cytochrome P450, family 4, subfamily a, polypeptide 32

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC18880

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables alkane 1-monooxygenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables alkane 1-monooxygenase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables arachidonate epoxygenase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables arachidonate monooxygenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables arachidonate monooxygenase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables leukotriene-B4 20-monooxygenase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables long-chain fatty acid omega-hydroxylase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in arachidonate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in arachidonate metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in epoxygenase P450 pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in icosanoid biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in icosanoid biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in kidney development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in lauric acid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in lauric acid metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in leukotriene metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in linoleic acid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in linoleic acid metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in long-chain fatty acid metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of icosanoid secretion ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in apical plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in intracellular membrane-bounded organelle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    cytochrome P450, family 4, subfamily a, polypeptide 31

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001252539.1 → NP_001239468.1  cytochrome P450, family 4, subfamily a, polypeptide 31 isoform 2

      See identical proteins and their annotated locations for NP_001239468.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon and uses an alternate splice site at the 5' end of a coding exon compared to variant 1, that causes a frameshift. The resulting isoform (2) lacks an alternate internal segment and has a shorter and distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AL626805
      Consensus CDS
      CCDS57291.1
      UniProtKB/TrEMBL
      Q91WU1, Q9QYM6
      Related
      ENSMUSP00000030480.4, ENSMUST00000030480.4
      Conserved Domains (1) summary
      pfam00067
      Location:52 → 414
      p450; Cytochrome P450

    2. NM_201640.3 → NP_964002.2  cytochrome P450, family 4, subfamily a, polypeptide 31 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AL626805
      Consensus CDS
      CCDS51273.1
      UniProtKB/TrEMBL
      A2A977, F8WGU9
      Related
      ENSMUSP00000030486.9, ENSMUST00000030486.15
      Conserved Domains (1) summary
      pfam00067
      Location:52 → 503
      p450; Cytochrome P450

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      115420824..115436212
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006503279.3 → XP_006503342.1  cytochrome P450, family 4, subfamily a, polypeptide 31 isoform X1

      UniProtKB/TrEMBL
      Q9QYM6
      Conserved Domains (1) summary
      pfam00067
      Location:52 → 429
      p450; Cytochrome P450
    Nucleotide Protein Strain
    Heading Accession and Version

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