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    Sardh sarcosine dehydrogenase [ Mus musculus (house mouse) ]

    Gene ID: 192166, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Sardhprovided by MGI
    Official Full Name
    sarcosine dehydrogenaseprovided by MGI
    Primary source
    MGI:MGI:2183102
    See related
    Ensembl:ENSMUSG00000009614 AllianceGenome:MGI:2183102
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to enable flavin adenine dinucleotide binding activity; folic acid binding activity; and sarcosine dehydrogenase activity. Predicted to be involved in sarcosine catabolic process and tetrahydrofolate interconversion. Located in mitochondrion. Is expressed in brain; future brain; hepatic primordium; and liver. Human ortholog(s) of this gene implicated in sarcosinemia. Orthologous to human SARDH (sarcosine dehydrogenase). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in liver adult (RPKM 211.5), kidney adult (RPKM 72.0) and 2 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Sardh in Genome Data Viewer
    Location:
    2 A3; 2 19.31 cM
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (27078405..27138344, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (27188393..27248332, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene dopamine beta hydroxylase, opposite strand Neighboring gene dopamine beta hydroxylase Neighboring gene vav 2 oncogene Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:27159262-27159371 Neighboring gene Vav2R10 erythroid cis-regulatory module Neighboring gene Vav2R3 erythroid cis-regulatory module Neighboring gene STARR-seq mESC enhancer starr_04000 Neighboring gene Vav2R7 erythroid cis-regulatory module Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:27269900-27270101 Neighboring gene STARR-seq mESC enhancer starr_04002 Neighboring gene Vav2R5 erythroid cis-regulatory module Neighboring gene bromodomain containing 3, opposite strand

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. sar: a genetic mouse model for human sarcosinemia generated by ethylnitrosourea mutagenesis. Harding CO, et al. Proc Natl Acad Sci U S A, 1992 Apr 1. PMID 1372986, Free PMC Article
    2. Endogenous formaldehyde is a memory-related molecule in mice and humans. Ai L, et al. Commun Biol, 2019. PMID 31815201, Free PMC Article
    3. Identification and characterization of proteins interacting with Traf4, an enigmatic p53 target. Rozan LM, et al. Cancer Biol Ther, 2006 Sep. PMID 16969126
    4. Liver and brain differential expression of one-carbon metabolism genes during ontogenesis. Imbard A, et al. Sci Rep, 2021 Oct 26. PMID 34702858, Free PMC Article
    5. Essential roles of mitochondrial biogenesis regulator Nrf1 in retinal development and homeostasis. Kiyama T, et al. Mol Neurodegener, 2018 Oct 17. PMID 30333037, Free PMC Article

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC6279

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables flavin adenine dinucleotide binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables folic acid binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables sarcosine dehydrogenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sarcosine dehydrogenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sarcosine dehydrogenase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in sarcosine catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in tetrahydrofolate interconversion ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in mitochondrial matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrial matrix IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial matrix ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    sarcosine dehydrogenase, mitochondrial
    NP_619606.1
    XP_006497851.1
    XP_006497852.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_138665.2 → NP_619606.1  sarcosine dehydrogenase, mitochondrial

      See identical proteins and their annotated locations for NP_619606.1

      Status: VALIDATED

      Source sequence(s)
      AK163515, AL731552, AW495221
      Consensus CDS
      CCDS15826.1
      UniProtKB/Swiss-Prot
      Q99LB7
      UniProtKB/TrEMBL
      Q3TQD9, Q3TWI2
      Related
      ENSMUSP00000099950.4, ENSMUST00000102886.10
      Conserved Domains (3) summary
      COG0404
      Location:480 → 917
      GcvT; Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]
      COG0665
      Location:64 → 448
      DadA; Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism]
      pfam16350
      Location:431 → 486
      FAO_M; FAD dependent oxidoreductase central domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      27078405..27138344 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006497789.5 → XP_006497852.1  sarcosine dehydrogenase, mitochondrial isoform X1

      See identical proteins and their annotated locations for XP_006497852.1

      UniProtKB/Swiss-Prot
      Q99LB7
      UniProtKB/TrEMBL
      Q3TQD9, Q3TWI2
      Conserved Domains (3) summary
      COG0404
      Location:480 → 917
      GcvT; Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]
      COG0665
      Location:64 → 448
      DadA; Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism]
      pfam16350
      Location:431 → 486
      FAO_M; FAD dependent oxidoreductase central domain

    2. XM_006497788.5 → XP_006497851.1  sarcosine dehydrogenase, mitochondrial isoform X1

      See identical proteins and their annotated locations for XP_006497851.1

      UniProtKB/Swiss-Prot
      Q99LB7
      UniProtKB/TrEMBL
      Q3TQD9, Q3TWI2
      Conserved Domains (3) summary
      COG0404
      Location:480 → 917
      GcvT; Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]
      COG0665
      Location:64 → 448
      DadA; Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism]
      pfam16350
      Location:431 → 486
      FAO_M; FAD dependent oxidoreductase central domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q99LB7.1 GenPept UniProtKB/Swiss-Prot:Q99LB7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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