Fshb follicle stimulating hormone beta [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Fshbprovided by MGI
Official Full Name: follicle stimulating hormone betaprovided by MGI
Primary source: MGI:MGI:95582
See related: Ensembl:ENSMUSG00000027120 AllianceGenome:MGI:95582
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: FSH; FSH-B; Fshbeta; FSH-beta
Summary: The pituitary glycoprotein hormone family includes follicle-stimulating hormone, luteinizing hormone, chorionic gonadotropin, and thyroid-stimulating hormone. All of these glycoproteins consist of an identical alpha subunit and a hormone-specific beta subunit. This gene encodes the beta subunit of follicle-stimulating hormone. In conjunction with luteinizing hormone, follicle-stimulating hormone induces egg and sperm production. [provided by RefSeq, Aug 2015]
Orthologs: human all
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Genomic context

Location:: 2 E3; 2 56.02 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (106886331..106889996, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (107055986..107059651, complement)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Identification of follicle-stimulating hormone-responsive genes in Sertoli cells during early postnatal mouse testis development.
Title: Identification of follicle-stimulating hormone-responsive genes in Sertoli cells during early postnatal mouse testis development.
Mutual Effects of Orexin and Bone Morphogenetic Proteins on Gonadotropin Expression by Mouse Gonadotrope Cells.
Title: Mutual Effects of Orexin and Bone Morphogenetic Proteins on Gonadotropin Expression by Mouse Gonadotrope Cells.
Effects of umbilical cord mesenchymal stem cells on expression of CYR61, FSH, and AMH in mice with premature ovarian failure.
Title: Effects of umbilical cord mesenchymal stem cells on expression of CYR61, FSH, and AMH in mice with premature ovarian failure.
A speech planning network for interactive language use.
Title: A speech planning network for interactive language use.
FSH directly regulates chondrocyte dedifferentiation and cartilage development.
Title: FSH directly regulates chondrocyte dedifferentiation and cartilage development.
Human Follicle-Stimulating Hormone ss Subunit Expression Depends on FOXL2 and SMAD4.
Title: Human Follicle-Stimulating Hormone ß Subunit Expression Depends on FOXL2 and SMAD4.
Murine FSH Production Depends on the Activin Type II Receptors ACVR2A and ACVR2B.
Title: Murine FSH Production Depends on the Activin Type II Receptors ACVR2A and ACVR2B.
FSH signaling is involved in affective disorders.
Title: FSH signaling is involved in affective disorders.
Our current findings show that elevated FSH had minimal disruption of either embryo developmental capacity or uterine function when examined in isolation, and the subfertility of TgFSH female mice was not caused by altered oocyte aneuploidy or quality.
Title: Reproductive failure in mice expressing transgenic follicle-stimulating hormone is not caused by loss of oocyte quality.
FSH enhances CRTC2-mediated gluconeogenesis dependent on AMPK Ser485 phosphorylation via GRK2 in the liver, suggesting an essential role of FSH in the pathogenesis of fasting hyperglycaemia
Title: Follicle-stimulating hormone enhances hepatic gluconeogenesis by GRK2-mediated AMPK hyperphosphorylation at Ser485 in mice.

Submit: New GeneRIF Correction See all GeneRIFs (53)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (1) 1 citation

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables follicle-stimulating hormone activity	IBA Inferred from Biological aspect of Ancestor more info
enables follicle-stimulating hormone activity	ISO Inferred from Sequence Orthology more info
enables follicle-stimulating hormone activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in G protein-coupled receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within Sertoli cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in follicle-stimulating hormone signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within follicle-stimulating hormone signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within ovarian follicle development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of bone resorption	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of gene expression	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of steroid biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of steroid biosynthetic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of osteoclast differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of signaling receptor activity	ISO Inferred from Sequence Orthology more info
involved_in regulation of signaling receptor activity	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within spermatogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in transforming growth factor beta receptor signaling pathway	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in extracellular space	ISS Inferred from Sequence or Structural Similarity more info
part_of follicle-stimulating hormone complex	ISO Inferred from Sequence Orthology more info
part_of follicle-stimulating hormone complex	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: follitropin subunit beta

Names: follicle-stimulating hormone beta subunit; follitropin beta chain

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.