Trdmt1 tRNA aspartic acid methyltransferase 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Trdmt1provided by MGI
Official Full Name: tRNA aspartic acid methyltransferase 1provided by MGI
Primary source: MGI:MGI:1274787
See related: Ensembl:ENSMUSG00000026723 AllianceGenome:MGI:1274787
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Dnmt2; Rnmt2; met-2; m.MmuIIP
Summary: Enables tRNA (cytidine-5-)-methyltransferase activity. Involved in tRNA methylation and tRNA stabilization. Predicted to be located in cytoplasm. Predicted to be active in nucleus. Is expressed in several structures, including central nervous system; genitourinary system; hemolymphoid system gland; olfactory epithelium; and thyroid gland. Orthologous to human TRDMT1 (tRNA aspartic acid methyltransferase 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in CNS E18 (RPKM 2.1), bladder adult (RPKM 2.0) and 27 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 A1; 2 10.0 cM

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (13509690..13549475, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (13504879..13544797, complement)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Suppression of DNMT2/3 by proinflammatory cytokines inhibits CtBP1/2-dependent genes to promote the occurrence of atrophic nonunion.
Title: Suppression of DNMT2/3 by proinflammatory cytokines inhibits CtBP1/2-dependent genes to promote the occurrence of atrophic nonunion.
Dnmt2-null sperm block maternal transmission of a paramutant phenotypedagger.
Title: Dnmt2-null sperm block maternal transmission of a paramutant phenotype†.
We also show that Q-dependent stimulation of Dnmt2 is conserved in mice. Our findings reveal a direct mechanism for the regulation of translational speed and fidelity in eukaryotes by a nutrient originating from bacteria.
Title: Queuine links translational control in eukaryotes to a micronutrient from bacteria.
Dnmt2 functions as a genetic factor that is essential in shaping the sperm RNA 'coding signature that is responsible for the intergenerational transmission of HFD-induced paternal metabolic disorders.
Title: Dnmt2 mediates intergenerational transmission of paternally acquired metabolic disorders through sperm small non-coding RNAs.
Dnmt2 may promote lifespan in the control conditions and survival during stress conditions in mouse fibroblasts.
Title: Downregulation of methyltransferase Dnmt2 results in condition-dependent telomere shortening and senescence or apoptosis in mouse fibroblasts.
Dnmt2 plays an unexpected role for regulation of cardiac growth by modulating activity of the P-TEFb complex.
Title: Dnmt2/Trdmt1 as Mediator of RNA Polymerase II Transcriptional Activity in Cardiac Growth.
Treatment of aged mice and their derived macrophages with methyltransferase inhibitor (2)-epigallocatechin-3-gallate (EGCG) or specific DNA methyltransferase 2 (DNMT2) siRNA restored the expression of Atg5 and LC3 in vivo and in vitro.
Title: Aging is associated with hypermethylation of autophagy genes in macrophages.
Dnmt2 plays an important role in haematopoiesis and define a novel function of C38 tRNA methylation in the discrimination of near-cognate codons, thereby ensuring accurate polypeptide synthesis.
Title: The tRNA methyltransferase Dnmt2 is required for accurate polypeptide synthesis during haematopoiesis.
these findings uncover a novel function of Dnmt2 in RNA-mediated epigenetic heredity
Title: RNA-mediated epigenetic heredity requires the cytosine methyltransferase Dnmt2.
Dnmt2-dependent methylomes lack defined DNA methylation patterns.
Title: Dnmt2-dependent methylomes lack defined DNA methylation patterns.

Submit: New GeneRIF Correction See all GeneRIFs (12)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4)
Gene trapped (1)
Targeted (4) 1 citation

General gene information

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Markers

Trdmt1 (e-PCR), detects polymorphism
- UniSTS:472924

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables tRNA (cytidine-5-)-methyltransferase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables tRNA (cytidine-5-)-methyltransferase activity	ISO Inferred from Sequence Orthology more info
enables tRNA methyltransferase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables tRNA methyltransferase activity	ISO Inferred from Sequence Orthology more info	PubMed

Process	Evidence Code	Pubs
involved_in response to amphetamine	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within tRNA methylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in tRNA methylation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within tRNA methylation	ISO Inferred from Sequence Orthology more info	PubMed
involved_in tRNA modification	ISO Inferred from Sequence Orthology more info
involved_in tRNA stabilization	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: tRNA (cytosine(38)-C(5))-methyltransferase

Names: DNA (cytosine-5)-methyltransferase-like protein 2; DNA MTase homolog MmuIIP; DNA methyltransferase 2; DNA methyltransferase homolog MmuIIP; tRNA (cytosine-5-)-methyltransferase

NP_001403924.1

EC 2.1.1.204

NP_001403925.1

EC 2.1.1.204

NP_001403926.1

EC 2.1.1.204

NP_001403927.1

EC 2.1.1.204

NP_001403928.1

EC 2.1.1.204

NP_034197.3

EC 2.1.1.204

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001416995.1 → NP_001403924.1 tRNA (cytosine(38)-C(5))-methyltransferase isoform 2

Status: VALIDATED

Source sequence(s)

AL772303, AL773538
NM_001416996.1 → NP_001403925.1 tRNA (cytosine(38)-C(5))-methyltransferase isoform 2

Status: VALIDATED

Source sequence(s)

AL772303, AL773538
NM_001416997.1 → NP_001403926.1 tRNA (cytosine(38)-C(5))-methyltransferase isoform 3

Status: VALIDATED

Source sequence(s)

AL772303, AL773538
NM_001416998.1 → NP_001403927.1 tRNA (cytosine(38)-C(5))-methyltransferase isoform 3

Status: VALIDATED

Source sequence(s)

AL772303, AL773538
NM_001416999.1 → NP_001403928.1 tRNA (cytosine(38)-C(5))-methyltransferase isoform 4

Status: VALIDATED

Source sequence(s)

AL772303, AL773538
NM_010067.5 → NP_034197.3 tRNA (cytosine(38)-C(5))-methyltransferase isoform 1

See identical proteins and their annotated locations for NP_034197.3

Status: VALIDATED

Source sequence(s)

AL772303, AL773538

Consensus CDS

CCDS15695.1

UniProtKB/Swiss-Prot

O35212, O55055

UniProtKB/TrEMBL

Q5I0V6, Q8C7F0

Related

ENSMUSP00000114572.2, ENSMUST00000124488.7

Conserved Domains (1) summary

cd00315
Location:4 → 391

Cyt_C5_DNA_methylase; Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group ...

RNA

NR_184406.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AL772303, AL773538
NR_184407.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AL772303, AL773538