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    Adat3 adenosine deaminase, tRNA-specific 3 [ Mus musculus (house mouse) ]

    Gene ID: 100113398, updated on 27-Nov-2024

    Summary

    Official Symbol
    Adat3provided by MGI
    Official Full Name
    adenosine deaminase, tRNA-specific 3provided by MGI
    Primary source
    MGI:MGI:1924344
    See related
    Ensembl:ENSMUSG00000113640 AllianceGenome:MGI:1924344
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    A430024H01Rik
    Summary
    Predicted to enable catalytic activity and metal ion binding activity. Predicted to contribute to tRNA-specific adenosine-34 deaminase activity. Predicted to be involved in tRNA processing. Predicted to be active in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in neurodevelopmental disorder with brain abnormalities, poor growth, and dysmorphic facies. Orthologous to human ADAT3 (adenosine deaminase tRNA specific 3). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in ovary adult (RPKM 16.7), testis adult (RPKM 16.7) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Adat3 in Genome Data Viewer
    Location:
    10 C1; 10 39.72 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (80438714..80443488)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (80602880..80607654)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E11446 Neighboring gene predicted gene, 26710 Neighboring gene abhydrolase domain containing 17A Neighboring gene STARR-positive B cell enhancer ABC_E2950 Neighboring gene STARR-positive B cell enhancer ABC_E6883 Neighboring gene secretory carrier membrane protein 4 Neighboring gene microRNA 6912 Neighboring gene predicted gene, 31298

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    General gene information

    Potential readthrough

    Included gene: Scamp4

    Clone Names

    • MGC65589

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    contributes_to tRNA-specific adenosine-34 deaminase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in tRNA processing IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    probable inactive tRNA-specific adenosine deaminase-like protein 3
    Names
    adenosine deaminase, tRNA-specific 3, TAD2 homolog
    tRNA-specific adenosine deaminase 3
    tRNA-specific adenosine deaminase-like protein 3
    tRNA-specific adenosine-34 deaminase subunit ADAT3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001100606.1NP_001094076.1  probable inactive tRNA-specific adenosine deaminase-like protein 3

      See identical proteins and their annotated locations for NP_001094076.1

      Status: VALIDATED

      Source sequence(s)
      AK020747, BX632866, BY036102
      Consensus CDS
      CCDS48637.1
      UniProtKB/Swiss-Prot
      Q6PAT0
      Related
      ENSMUSP00000040551.5, ENSMUST00000038411.5
      Conserved Domains (1) summary
      COG0590
      Location:195345
      TadA; tRNA(Arg) A34 adenosine deaminase TadA [Translation, ribosomal structure and biogenesis]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      80438714..80443488
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)