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    Blvrb biliverdin reductase B [ Mus musculus (house mouse) ]

    Gene ID: 233016, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Blvrbprovided by MGI
    Official Full Name
    biliverdin reductase Bprovided by MGI
    Primary source
    MGI:MGI:2385271
    See related
    Ensembl:ENSMUSG00000040466 AllianceGenome:MGI:2385271
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Enables peptidyl-cysteine S-nitrosylase activity. Involved in negative regulation of insulin receptor signaling pathway. Predicted to be located in several cellular components, including cytosol; nucleoplasm; and terminal bouton. Predicted to be active in cytoplasm. Is expressed in liver; nervous system; respiratory system; and sensory organ. Orthologous to human BLVRB (biliverdin reductase B). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in liver E14.5 (RPKM 398.9), liver E14 (RPKM 344.3) and 15 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Blvrb in Genome Data Viewer
    Location:
    7 A3; 7 15.9 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (27147403..27165406)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (27447978..27465981)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene Sh3kbp1 binding protein 1 Neighboring gene STARR-positive B cell enhancer ABC_E1726 Neighboring gene STARR-positive B cell enhancer ABC_E1727 Neighboring gene STARR-positive B cell enhancer ABC_E2820 Neighboring gene spectrin beta, non-erythrocytic 4 Neighboring gene STARR-seq mESC enhancer starr_18360 Neighboring gene STARR-positive B cell enhancer ABC_E4908 Neighboring gene STARR-positive B cell enhancer ABC_E2230 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:28258388-28258575 Neighboring gene phosphoglycerate mutase 1, pseudogene 2 Neighboring gene STARR-positive B cell enhancer ABC_E1336 Neighboring gene SERTA domain containing 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Divergent erythroid megakaryocyte fates in Blvrb-deficient mice establish non-overlapping cytoprotective functions during stress hematopoiesis. Nesbitt NM, et al. Free Radic Biol Med, 2021 Feb 20. PMID 33359909, Free PMC Article
    2. Biliverdin Reductase B Is a Plasma Biomarker for Intraplaque Hemorrhage and a Predictor of Ischemic Stroke in Patients with Symptomatic Carotid Atherosclerosis. Chemaly M, et al. Biomolecules, 2023 May 24. PMID 37371462, Free PMC Article
    3. An enzyme that selectively S-nitrosylates proteins to regulate insulin signaling. Zhou HL, et al. Cell, 2023 Dec 21. PMID 38056462,
    4. DLK1 is a novel regulator of bone mass that mediates estrogen deficiency-induced bone loss in mice. Abdallah BM, et al. J Bone Miner Res, 2011 Jul. PMID 21308776
    5. LCP1 preferentially binds clasped αMβ2 integrin and attenuates leukocyte adhesion under flow. Tseng HY, et al. J Cell Sci, 2018 Nov 21. PMID 30333137, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Biliverdin Reductase B Is a Plasma Biomarker for Intraplaque Hemorrhage and a Predictor of Ischemic Stroke in Patients with Symptomatic Carotid Atherosclerosis.
      Title: Biliverdin Reductase B Is a Plasma Biomarker for Intraplaque Hemorrhage and a Predictor of Ischemic Stroke in Patients with Symptomatic Carotid Atherosclerosis.
    2. Divergent erythroid megakaryocyte fates in Blvrb-deficient mice establish non-overlapping cytoprotective functions during stress hematopoiesis.
      Title: Divergent erythroid megakaryocyte fates in Blvrb-deficient mice establish non-overlapping cytoprotective functions during stress hematopoiesis.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Clone Names

    • MGC11726, MGC27866

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables FMN reductase (NAD(P)H) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables FMN reductase (NADH) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables FMN reductase (NADPH) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables biliverdin reductase [NAD(P)+] activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables biliverdin reductase [NAD(P)+] activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables biliverdin reductase [NAD(P)+] activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables peptidyl-cysteine S-nitrosylase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables peptidyl-cysteine S-nitrosylase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables peptidyl-cysteine S-nitrosylase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables riboflavin reductase (NADPH) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables riboflavin reductase (NADPH) activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables riboflavin reductase (NADPH) activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in heme catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in heme catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in megakaryocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in megakaryocyte differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of insulin receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of insulin receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in terminal bouton ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    flavin reductase (NADPH)
    Names
    BVR-B
    FLR
    FR
    NADPH-dependent diaphorase
    NADPH-flavin reductase
    S-nitroso-CoA-assisted nitrosyltransferase
    SNO-CoA-assisted nitrosyltransferase
    biliverdin-IX beta-reductase
    NP_001277454.1
    NP_659172.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001290525.1 → NP_001277454.1  flavin reductase (NADPH) isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains an alternate first exon compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1.
      Source sequence(s)
      AC158304
      Consensus CDS
      CCDS71922.1
      UniProtKB/TrEMBL
      E9PZC4
      Related
      ENSMUSP00000103994.2, ENSMUST00000108357.8
      Conserved Domains (2) summary
      COG0451
      Location:3 → 68
      WcaG; Nucleoside-diphosphate-sugar epimerase [Cell wall/membrane/envelope biogenesis]
      cl21454
      Location:1 → 114
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    2. NM_144923.3 → NP_659172.1  flavin reductase (NADPH) isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC158304
      Consensus CDS
      CCDS39848.1
      UniProtKB/Swiss-Prot
      Q923D2
      UniProtKB/TrEMBL
      Q3U6G1
      Related
      ENSMUSP00000043092.10, ENSMUST00000037399.16
      Conserved Domains (2) summary
      cd05244
      Location:5 → 200
      BVR-B_like_SDR_a; biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs
      COG0451
      Location:4 → 154
      WcaG; Nucleoside-diphosphate-sugar epimerase [Cell wall/membrane/envelope biogenesis]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      27147403..27165406
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q923D2.3 GenPept UniProtKB/Swiss-Prot:Q923D2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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