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    Zic1 zinc finger protein of the cerebellum 1 [ Mus musculus (house mouse) ]

    Gene ID: 22771, updated on 9-Dec-2024

    Summary

    Official Symbol
    Zic1provided by MGI
    Official Full Name
    zinc finger protein of the cerebellum 1provided by MGI
    Primary source
    MGI:MGI:106683
    See related
    Ensembl:ENSMUSG00000032368 AllianceGenome:MGI:106683
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    ZIC; ZNF201
    Summary
    Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including central nervous system development; positive regulation of protein import into nucleus; and positive regulation of transcription by RNA polymerase II. Acts upstream of or within adult walking behavior and central nervous system development. Located in cytoplasm and nucleus. Is expressed in several structures, including central nervous system; embryo mesenchyme; future brain; metanephros; and visual system. Used to study Dandy-Walker syndrome and Joubert syndrome. Human ortholog(s) of this gene implicated in Dandy-Walker syndrome and craniosynostosis. Orthologous to human ZIC1 (Zic family member 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in cerebellum adult (RPKM 92.7), whole brain E14.5 (RPKM 45.5) and 4 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Zic1 in Genome Data Viewer
    Location:
    9 E3.2; 9 48.26 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (91240111..91250136, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (91358058..91365768, complement)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA A730094K22 gene Neighboring gene methionyl aminopeptidase 1 pseudogene Neighboring gene predicted gene, 40546 Neighboring gene predicted gene, 40545 Neighboring gene zinc finger protein of the cerebellum 4 Neighboring gene predicted gene 29478 Neighboring gene predicted gene, 39400

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (3)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    acts_upstream_of_or_within adult walking behavior IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in brain development IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in brain development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cell cycle IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in central nervous system development IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within central nervous system development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within central nervous system development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in forebrain development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in gene expression IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in hippocampus development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in inner ear morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in maintenance of cell number IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in olfactory bulb development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in pattern specification process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of protein import into nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of smoothened signaling pathway IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in skeletal system development NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in spinal cord development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    zinc finger protein ZIC 1
    Names
    Zic family member 1 (odd-paired homolog, Drosophila)
    odd-paired homolog

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001376941.1NP_001363870.1  zinc finger protein ZIC 1

      Status: VALIDATED

      Description
      Transcript Variant: Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC116582, AK141431, BC060247, CD741655
      UniProtKB/Swiss-Prot
      P46684, Q6PAK5, Q80Y18
      UniProtKB/TrEMBL
      Q3TWA9
      Related
      ENSMUSP00000068858.4, ENSMUST00000065360.5
      Conserved Domains (3) summary
      COG5189
      Location:298382
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:276296
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam18366
      Location:219264
      zf_ZIC; Zic proteins zinc finger domain
    2. NM_009573.4NP_033599.2  zinc finger protein ZIC 1

      See identical proteins and their annotated locations for NP_033599.2

      Status: VALIDATED

      Description
      Transcript Variant: Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK141431, BC063247, BY261991, CD741655, CN666056
      Consensus CDS
      CCDS23403.1
      UniProtKB/Swiss-Prot
      P46684, Q6PAK5, Q80Y18
      UniProtKB/TrEMBL
      Q3TWA9
      Related
      ENSMUSP00000034927.7, ENSMUST00000034927.13
      Conserved Domains (3) summary
      COG5189
      Location:298382
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:276296
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam18366
      Location:219264
      zf_ZIC; Zic proteins zinc finger domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      91240111..91250136 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036154847.1XP_036010740.1  zinc finger protein ZIC 1 isoform X1

      UniProtKB/Swiss-Prot
      P46684, Q6PAK5, Q80Y18
      UniProtKB/TrEMBL
      Q3TWA9
      Conserved Domains (3) summary
      COG5189
      Location:298382
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:276296
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam18366
      Location:219264
      zf_ZIC; Zic proteins zinc finger domain