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    Slc25a41 solute carrier family 25, member 41 [ Mus musculus (house mouse) ]

    Gene ID: 103775, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Slc25a41provided by MGI
    Official Full Name
    solute carrier family 25, member 41provided by MGI
    Primary source
    MGI:MGI:2144215
    See related
    Ensembl:ENSMUSG00000011486 AllianceGenome:MGI:2144215
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    SCaMC-3L; 4933406J04Rik
    Summary
    Enables ADP transmembrane transporter activity and ATP transmembrane transporter activity. Involved in mitochondrial ADP transmembrane transport and mitochondrial ATP transmembrane transport. Located in mitochondrion. Orthologous to human SLC25A41 (solute carrier family 25 member 41). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in testis adult (RPKM 9.3), ovary adult (RPKM 3.9) and 12 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Slc25a41 in Genome Data Viewer
    Location:
    17 D; 17 29.63 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (57339772..57348654, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (57032772..57041654, complement)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene adenylate kinase 5 pseudogene Neighboring gene KH-type splicing regulatory protein Neighboring gene STARR-positive B cell enhancer ABC_E142 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:57171392-57171575 Neighboring gene solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 23 Neighboring gene STARR-positive B cell enhancer ABC_E3211 Neighboring gene crumbs family member 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Characterization of SCaMC-3-like/slc25a41, a novel calcium-independent mitochondrial ATP-Mg/Pi carrier. Traba J, et al. Biochem J, 2009 Feb 15. PMID 18928449
    2. CRISPR/Cas9-mediated genome editing reveals 12 testis-enriched genes dispensable for male fertility in mice. Oyama Y, et al. Asian J Androl, 2022 May-Jun. PMID 34290169, Free PMC Article
    3. Fourteen novel human members of mitochondrial solute carrier family 25 (SLC25) widely expressed in the central nervous system. Haitina T, et al. Genomics, 2006 Dec. PMID 16949250
    4. Resistance to noise-induced hearing loss in 129S6 and MOLF mice: identification of independent, overlapping, and interacting chromosomal regions. Street VA, et al. J Assoc Res Otolaryngol, 2014 Oct. PMID 24952082, Free PMC Article
    5. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. mouse SCaMC-3L shows a limited expression pattern; it is preferentially expressed in testis and, at lower levels, in brain
      Title: Characterization of SCaMC-3-like/slc25a41, a novel calcium-independent mitochondrial ATP-Mg/Pi carrier.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ADP transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables ATP transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ATP transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in ADP transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ADP transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ATP transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ATP transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitochondrial ADP transmembrane transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitochondrial ATP transmembrane transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    calcium-independent mitochondrial carrier protein SCaMC-3L
    Names
    SCaMC-3-like
    mitochondrial ATP-Mg/Pi carrier protein
    mitochondrial ATP-Mg/Pi carrier protein SLC25A41
    small calcium-binding mitochondrial carrier protein 3-like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001346527.1 → NP_001333456.1  calcium-independent mitochondrial carrier protein SCaMC-3L isoform 2

      Status: VALIDATED

      Source sequence(s)
      CT571247
      Consensus CDS
      CCDS84326.1
      UniProtKB/Swiss-Prot
      Q8BVN7
      Related
      ENSMUSP00000130857.2, ENSMUST00000169012.2

    2. NM_175333.3 → NP_780542.1  calcium-independent mitochondrial carrier protein SCaMC-3L isoform 1

      See identical proteins and their annotated locations for NP_780542.1

      Status: VALIDATED

      Source sequence(s)
      AK077111, BX637138
      Consensus CDS
      CCDS37668.1
      UniProtKB/Swiss-Prot
      B8ZHC8, Q14BV4, Q8BVN7
      Related
      ENSMUSP00000058877.8, ENSMUST00000058661.14
      Conserved Domains (2) summary
      PTZ00169
      Location:23 → 305
      PTZ00169; ADP/ATP transporter on adenylate translocase; Provisional
      pfam00153
      Location:25 → 116
      Mito_carr; Mitochondrial carrier protein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      57339772..57348654 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BVN7.1 GenPept UniProtKB/Swiss-Prot:Q8BVN7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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