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    Mtus2 microtubule associated tumor suppressor candidate 2 [ Mus musculus (house mouse) ]

    Gene ID: 77521, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Mtus2provided by MGI
    Official Full Name
    microtubule associated tumor suppressor candidate 2provided by MGI
    Primary source
    MGI:MGI:1915388
    See related
    Ensembl:ENSMUSG00000029651 AllianceGenome:MGI:1915388
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Cazip; Gm763; mKIAA0774; 5730592G18Rik; A730013O20Rik; C130038G02Rik
    Summary
    Predicted to enable microtubule binding activity and protein homodimerization activity. Predicted to be located in intercellular bridge and microtubule cytoskeleton. Predicted to be active in nucleus. Predicted to colocalize with centrosome and cytoplasmic microtubule. Is expressed in several structures, including central nervous system; eye; heart; peripheral nervous system; and respiratory system. Orthologous to human MTUS2 (microtubule associated scaffold protein 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in heart adult (RPKM 15.8), cerebellum adult (RPKM 6.4) and 12 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Mtus2 in Genome Data Viewer
    Location:
    5 G3; 5 87.82 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (147894085..148252875)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (147957275..148316065)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E534 Neighboring gene solute carrier family 46, member 3 Neighboring gene STARR-seq mESC enhancer starr_14888 Neighboring gene predicted gene, 46943 Neighboring gene STARR-seq mESC enhancer starr_14889 Neighboring gene STARR-seq mESC enhancer starr_14890 Neighboring gene STARR-seq mESC enhancer starr_14891 Neighboring gene STARR-seq mESC enhancer starr_14892 Neighboring gene STARR-seq mESC enhancer starr_14893 Neighboring gene STARR-seq mESC enhancer starr_14894 Neighboring gene predicted gene, 46928 Neighboring gene STARR-seq mESC enhancer starr_14896 Neighboring gene fused in sarcoma pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E675 Neighboring gene solute carrier family 7 (cationic amino acid transporter, y+ system), member 1 Neighboring gene STARR-seq mESC enhancer starr_14901 Neighboring gene STARR-positive B cell enhancer mm9_chr5:149263482-149263782 Neighboring gene STARR-seq mESC enhancer starr_14907 Neighboring gene ubiquitin-like 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. CAZIP, a novel protein expressed in the developing heart and nervous system. Du Puy L, et al. Dev Dyn, 2009 Nov. PMID 19806667
    2. Prediction of the coding sequences of mouse homologues of KIAA gene: I. The complete nucleotide sequences of 100 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2002 Oct 31. PMID 12465718
    3. Cracking the egg: molecular dynamics and evolutionary aspects of the transition from the fully grown oocyte to embryo. Evsikov AV, et al. Genes Dev, 2006 Oct 1. PMID 17015433, Free PMC Article
    4. Hdac4 Interactions in Huntington's Disease Viewed Through the Prism of Multiomics. Federspiel JD, et al. Mol Cell Proteomics, 2019 Aug 9. PMID 31040226, Free PMC Article
    5. Identification of transcripts with enriched expression in the developing and adult pancreas. Hoffman BG, et al. Genome Biol, 2008. PMID 18554416, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables microtubule binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables microtubule binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein homodimerization activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    colocalizes_with centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    colocalizes_with centrosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    colocalizes_with cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    colocalizes_with cytoplasmic microtubule ISO
    Inferred from Sequence Orthology
    more info
    		  
    colocalizes_with cytoplasmic microtubule ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in intercellular bridge IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in intercellular bridge ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in microtubule cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    microtubule-associated tumor suppressor candidate 2 homolog
    Names
    cardiac zipper protein
    microtubule plus-end tracking protein TIP150
    tracking protein of 150 kDa

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001359503.2 → NP_001346432.1  microtubule-associated tumor suppressor candidate 2 homolog isoform a

      Status: VALIDATED

      Source sequence(s)
      AC109498, AC117725, AC133954, AC158301
      Consensus CDS
      CCDS19881.1
      UniProtKB/Swiss-Prot
      B9EKJ2, Q3UHD3, Q7TPP7, Q8CHD2, Q9CY74
      Conserved Domains (2) summary
      PHA03247
      Location:516 → 974
      PHA03247; large tegument protein UL36; Provisional
      COG0419
      Location:1024 → 1313
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]

    2. NM_001359505.2 → NP_001346434.1  microtubule-associated tumor suppressor candidate 2 homolog isoform b

      Status: VALIDATED

      Source sequence(s)
      AC109498, AC158301
      UniProtKB/TrEMBL
      D3YZ69
      Related
      ENSMUSP00000106144.3, ENSMUST00000110515.9
      Conserved Domains (1) summary
      cl25732
      Location:25 → 318
      SMC_N; RecF/RecN/SMC N terminal domain

    3. NM_001359511.2 → NP_001346440.1  microtubule-associated tumor suppressor candidate 2 homolog isoform c

      Status: VALIDATED

      Source sequence(s)
      AC109498, AC158301
      UniProtKB/TrEMBL
      D3YY58, Q8C1S9
      Related
      ENSMUSP00000071775.6, ENSMUST00000071878.12

    4. NM_001416280.1 → NP_001403209.1  microtubule-associated tumor suppressor candidate 2 homolog isoform d

      Status: VALIDATED

      Source sequence(s)
      AC109498, AC158301
      Related
      ENSMUSP00000106143.2, ENSMUST00000110514.8

    5. NM_029920.8 → NP_084196.4  microtubule-associated tumor suppressor candidate 2 homolog isoform a

      See identical proteins and their annotated locations for NP_084196.4

      Status: VALIDATED

      Source sequence(s)
      AC109498, AC117725, AC133954, AC158301
      Consensus CDS
      CCDS19881.1
      UniProtKB/Swiss-Prot
      B9EKJ2, Q3UHD3, Q7TPP7, Q8CHD2, Q9CY74
      Related
      ENSMUSP00000082694.5, ENSMUST00000085558.11
      Conserved Domains (2) summary
      PHA03247
      Location:516 → 974
      PHA03247; large tegument protein UL36; Provisional
      COG0419
      Location:1024 → 1313
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      147894085..148252875
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011241018.3 → XP_011239320.1  microtubule-associated tumor suppressor candidate 2 homolog isoform X1

      Conserved Domains (2) summary
      PHA03247
      Location:516 → 974
      PHA03247; large tegument protein UL36; Provisional
      COG0419
      Location:1024 → 1280
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]

    2. XM_006504891.5 → XP_006504954.1  microtubule-associated tumor suppressor candidate 2 homolog isoform X2

      Conserved Domains (2) summary
      PHA03247
      Location:33 → 204
      PHA03247; large tegument protein UL36; Provisional
      COG0419
      Location:304 → 540
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3UHD3.1 GenPept UniProtKB/Swiss-Prot:Q3UHD3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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