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    Haus2 HAUS augmin-like complex, subunit 2 [ Mus musculus (house mouse) ]

    Gene ID: 66296, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Haus2provided by MGI
    Official Full Name
    HAUS augmin-like complex, subunit 2provided by MGI
    Primary source
    MGI:MGI:1913546
    See related
    Ensembl:ENSMUSG00000027285 AllianceGenome:MGI:1913546
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Cep27; 1700101G24Rik; 2410007P03Rik
    Summary
    Predicted to be involved in centrosome cycle; microtubule nucleation; and spindle assembly. Located in spindle microtubule. Orthologous to human HAUS2 (HAUS augmin like complex subunit 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in testis adult (RPKM 7.6), CNS E11.5 (RPKM 6.0) and 25 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Haus2 in Genome Data Viewer
    Location:
    2 E5; 2 60.37 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (120439863..120452041)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (120609382..120621560)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_05509 Neighboring gene zinc finger protein 106 Neighboring gene STARR-seq mESC enhancer starr_05510 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:120393240-120393349 Neighboring gene STARR-seq mESC enhancer starr_05511 Neighboring gene synaptosomal-associated protein 23 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:120435029-120435138 Neighboring gene STARR-seq mESC enhancer starr_05512 Neighboring gene STARR-positive B cell enhancer ABC_E414 Neighboring gene leucine rich repeat containing 57 Neighboring gene StAR related lipid transfer domain containing 9 Neighboring gene STARR-seq mESC enhancer starr_05514 Neighboring gene codanin 1 Neighboring gene tau tubulin kinase 2 Neighboring gene STARR-seq mESC enhancer starr_05516 Neighboring gene STARR-positive B cell enhancer ABC_E3396

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. γ-Tubulin Ring Complexes and EB1 play antagonistic roles in microtubule dynamics and spindle positioning. Bouissou A, et al. EMBO J, 2014 Jan 13. PMID 24421324, Free PMC Article
    2. Construction of a multi-functional cDNA library specific for mouse pancreatic islets and its application to microarray. Nishimura M, et al. DNA Res, 2004 Oct 31. PMID 15747579
    3. Systematic analysis of human protein complexes identifies chromosome segregation proteins. Hutchins JR, et al. Science, 2010 Apr 30. PMID 20360068, Free PMC Article
    4. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article
    5. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, et al. Development, 2000 Apr. PMID 10725249

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in centrosome cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in centrosome cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in centrosome cycle ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in microtubule nucleation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in spindle assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in spindle assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in spindle assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    part_of HAUS complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of HAUS complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of HAUS complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in centrosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in centrosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in mitotic spindle microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitotic spindle microtubule ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitotic spindle microtubule ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in spindle microtubule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    HAUS augmin-like complex subunit 2
    Names
    centrosomal protein 27
    centrosomal protein of 27 kDa

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001290807.1 → NP_001277736.1  HAUS augmin-like complex subunit 2 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains an alternate 5' terminal exon, and it thus differs in its 5' UTR and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (b) is shorter at the N-terminus, compared to isoform a.
      Source sequence(s)
      AK007106, AL772299, BC086677, BP766698
      Consensus CDS
      CCDS71120.1
      UniProtKB/Swiss-Prot
      Q9CQS9
      Related
      ENSMUSP00000106334.2, ENSMUST00000110706.2
      Conserved Domains (1) summary
      pfam15003
      Location:1 → 158
      HAUS2; HAUS augmin-like complex subunit 2

    2. NM_001290808.1 → NP_001277737.1  HAUS augmin-like complex subunit 2 isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an alternate exon in the 5' region, and it thus differs in its 5' UTR and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (c) is shorter at the N-terminus, compared to isoform a.
      Source sequence(s)
      AK012779, AL772299, BP766698, BY711279
      Conserved Domains (1) summary
      pfam15003
      Location:1 → 96
      HAUS2; HAUS augmin-like complex subunit 2

    3. NM_025475.3 → NP_079751.1  HAUS augmin-like complex subunit 2 isoform a

      See identical proteins and their annotated locations for NP_079751.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
      Source sequence(s)
      AK012779, AL772299, BC086677, BP766698, BY711279
      Consensus CDS
      CCDS16624.1
      UniProtKB/Swiss-Prot
      A2AKH8, A2AKI1, Q3V1R1, Q9CQS9, Q9CRI2, Q9D9D0
      Related
      ENSMUSP00000117299.2, ENSMUST00000124187.8
      Conserved Domains (1) summary
      pfam15003
      Location:8 → 198
      HAUS2; HAUS augmin-like complex subunit 2

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      120439863..120452041
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036162447.1 → XP_036018340.1  HAUS augmin-like complex subunit 2 isoform X1

      Conserved Domains (1) summary
      pfam15003
      Location:1 → 96
      HAUS2; HAUS augmin-like complex subunit 2
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9CQS9.1 GenPept UniProtKB/Swiss-Prot:Q9CQS9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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