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    Arhgap23 Rho GTPase activating protein 23 [ Mus musculus (house mouse) ]

    Gene ID: 58996, updated on 3-Dec-2024

    Summary

    Official Symbol
    Arhgap23provided by MGI
    Official Full Name
    Rho GTPase activating protein 23provided by MGI
    Primary source
    MGI:MGI:3697726
    See related
    Ensembl:ENSMUSG00000049807 AllianceGenome:MGI:3697726
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    A330041B18Rik
    Summary
    Predicted to enable GTPase activator activity. Predicted to be involved in signal transduction. Is expressed in several structures, including aorta; brain; endocrine gland; female reproductive system; and retina. Orthologous to human ARHGAP23 (Rho GTPase activating protein 23). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 28.9), lung adult (RPKM 24.8) and 28 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Arhgap23 in Genome Data Viewer
    Location:
    11 D; 11 60.97 cM
    Exon count:
    28
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (97295183..97393228)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (97404357..97502402)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 53647 Neighboring gene G protein-coupled receptor 179 Neighboring gene suppressor of cytokine signaling 7 Neighboring gene STARR-seq mESC enhancer starr_30603 Neighboring gene STARR-positive B cell enhancer ABC_E10709 Neighboring gene STARR-seq mESC enhancer starr_30610 Neighboring gene RIKEN cDNA 4933428G20 gene Neighboring gene STARR-positive B cell enhancer ABC_E11489 Neighboring gene STARR-positive B cell enhancer ABC_E11490 Neighboring gene STARR-positive B cell enhancer mm9_chr11:97394449-97394749 Neighboring gene SRC kinase signaling inhibitor 1 Neighboring gene STARR-seq mESC enhancer starr_30619 Neighboring gene RIKEN cDNA 2410003L11 gene Neighboring gene STARR-seq mESC enhancer starr_30621 Neighboring gene predicted gene, 38962

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (2) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General protein information

    Preferred Names
    rho GTPase-activating protein 23
    Names
    rho-type GTPase-activating protein 23

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001428751.1NP_001415680.1  rho GTPase-activating protein 23 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL596088
      UniProtKB/Swiss-Prot
      Q69ZH9, Q8BNY7, Q9JJD6
      UniProtKB/TrEMBL
      B1AQY2
    2. NM_021493.3NP_067468.2  rho GTPase-activating protein 23 isoform 2

      See identical proteins and their annotated locations for NP_067468.2

      Status: VALIDATED

      Source sequence(s)
      AL596088
      Consensus CDS
      CCDS36293.1
      UniProtKB/Swiss-Prot
      Q69ZH9, Q8BNY7, Q9JJD6
      UniProtKB/TrEMBL
      F8VQ11
      Related
      ENSMUSP00000103227.2, ENSMUST00000107601.8
      Conserved Domains (3) summary
      cd04395
      Location:692887
      RhoGAP_ARHGAP21; RhoGAP_ARHGAP21: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP21-like proteins. ArhGAP21 is a multi-domain protein, containing RhoGAP, PH and PDZ domains, and is believed to play a role in the organization of the ...
      cd01253
      Location:480600
      PH_ARHGAP21-like; ARHGAP21 and related proteins pleckstrin homology (PH) domain
      pfam00169
      Location:479598
      PH; PH domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      97295183..97393228
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006533867.3XP_006533930.1  rho GTPase-activating protein 23 isoform X6

      UniProtKB/Swiss-Prot
      Q69ZH9, Q8BNY7, Q9JJD6
      Conserved Domains (4) summary
      PHA03247
      Location:158560
      PHA03247; large tegument protein UL36; Provisional
      cd00992
      Location:23138
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd04395
      Location:8851080
      RhoGAP_ARHGAP21; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP21-like proteins. ArhGAP21 is a multi-domain protein, containing RhoGAP, PH and PDZ domains, and is believed to play a role in the organization of the cell-cell junction ...
      cd01253
      Location:673793
      PH_ARHGAP21-like; ARHGAP21 and related proteins pleckstrin homology (PH) domain
    2. XM_030246200.1XP_030102060.1  rho GTPase-activating protein 23 isoform X1

      UniProtKB/Swiss-Prot
      Q69ZH9, Q8BNY7, Q9JJD6
      Conserved Domains (4) summary
      PHA03247
      Location:77479
      PHA03247; large tegument protein UL36; Provisional
      cd00992
      Location:457
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd04395
      Location:804999
      RhoGAP_ARHGAP21; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP21-like proteins. ArhGAP21 is a multi-domain protein, containing RhoGAP, PH and PDZ domains, and is believed to play a role in the organization of the cell-cell junction ...
      cd01253
      Location:592712
      PH_ARHGAP21-like; ARHGAP21 and related proteins pleckstrin homology (PH) domain
    3. XM_036156873.1XP_036012766.1  rho GTPase-activating protein 23 isoform X1

      UniProtKB/Swiss-Prot
      Q69ZH9, Q8BNY7, Q9JJD6
      Conserved Domains (4) summary
      PHA03247
      Location:77479
      PHA03247; large tegument protein UL36; Provisional
      cd00992
      Location:457
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd04395
      Location:804999
      RhoGAP_ARHGAP21; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP21-like proteins. ArhGAP21 is a multi-domain protein, containing RhoGAP, PH and PDZ domains, and is believed to play a role in the organization of the cell-cell junction ...
      cd01253
      Location:592712
      PH_ARHGAP21-like; ARHGAP21 and related proteins pleckstrin homology (PH) domain
    4. XM_006533865.4XP_006533928.1  rho GTPase-activating protein 23 isoform X4

      UniProtKB/Swiss-Prot
      Q69ZH9, Q8BNY7, Q9JJD6
      Conserved Domains (4) summary
      PHA03247
      Location:176578
      PHA03247; large tegument protein UL36; Provisional
      cd00992
      Location:41156
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd04395
      Location:9031098
      RhoGAP_ARHGAP21; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP21-like proteins. ArhGAP21 is a multi-domain protein, containing RhoGAP, PH and PDZ domains, and is believed to play a role in the organization of the cell-cell junction ...
      cd01253
      Location:691811
      PH_ARHGAP21-like; ARHGAP21 and related proteins pleckstrin homology (PH) domain
    5. XM_006533866.4XP_006533929.1  rho GTPase-activating protein 23 isoform X5

      Related
      ENSMUSP00000112999.2, ENSMUST00000121799.8
      Conserved Domains (4) summary
      PHA03247
      Location:176578
      PHA03247; large tegument protein UL36; Provisional
      cd00992
      Location:41156
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd04395
      Location:9031098
      RhoGAP_ARHGAP21; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP21-like proteins. ArhGAP21 is a multi-domain protein, containing RhoGAP, PH and PDZ domains, and is believed to play a role in the organization of the cell-cell junction ...
      cd01253
      Location:691811
      PH_ARHGAP21-like; ARHGAP21 and related proteins pleckstrin homology (PH) domain
    6. XM_006533869.4XP_006533932.2  rho GTPase-activating protein 23 isoform X8

      Conserved Domains (4) summary
      PHA03247
      Location:77479
      PHA03247; large tegument protein UL36; Provisional
      cd00992
      Location:457
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd04395
      Location:804999
      RhoGAP_ARHGAP21; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP21-like proteins. ArhGAP21 is a multi-domain protein, containing RhoGAP, PH and PDZ domains, and is believed to play a role in the organization of the cell-cell junction ...
      cd01253
      Location:592712
      PH_ARHGAP21-like; ARHGAP21 and related proteins pleckstrin homology (PH) domain
    7. XM_006533868.5XP_006533931.2  rho GTPase-activating protein 23 isoform X8

      Conserved Domains (4) summary
      PHA03247
      Location:77479
      PHA03247; large tegument protein UL36; Provisional
      cd00992
      Location:457
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd04395
      Location:804999
      RhoGAP_ARHGAP21; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP21-like proteins. ArhGAP21 is a multi-domain protein, containing RhoGAP, PH and PDZ domains, and is believed to play a role in the organization of the cell-cell junction ...
      cd01253
      Location:592712
      PH_ARHGAP21-like; ARHGAP21 and related proteins pleckstrin homology (PH) domain
    8. XM_006533861.5XP_006533924.2  rho GTPase-activating protein 23 isoform X1

      UniProtKB/Swiss-Prot
      Q69ZH9, Q8BNY7, Q9JJD6
      Conserved Domains (4) summary
      PHA03247
      Location:77479
      PHA03247; large tegument protein UL36; Provisional
      cd00992
      Location:457
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd04395
      Location:804999
      RhoGAP_ARHGAP21; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP21-like proteins. ArhGAP21 is a multi-domain protein, containing RhoGAP, PH and PDZ domains, and is believed to play a role in the organization of the cell-cell junction ...
      cd01253
      Location:592712
      PH_ARHGAP21-like; ARHGAP21 and related proteins pleckstrin homology (PH) domain
    9. XM_006533862.5XP_006533925.2  rho GTPase-activating protein 23 isoform X2

      UniProtKB/Swiss-Prot
      Q69ZH9, Q8BNY7, Q9JJD6
      Conserved Domains (4) summary
      PHA03247
      Location:77479
      PHA03247; large tegument protein UL36; Provisional
      cd00992
      Location:457
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd04395
      Location:804999
      RhoGAP_ARHGAP21; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP21-like proteins. ArhGAP21 is a multi-domain protein, containing RhoGAP, PH and PDZ domains, and is believed to play a role in the organization of the cell-cell junction ...
      cd01253
      Location:592712
      PH_ARHGAP21-like; ARHGAP21 and related proteins pleckstrin homology (PH) domain
    10. XM_006533863.5XP_006533926.2  rho GTPase-activating protein 23 isoform X3

      UniProtKB/Swiss-Prot
      Q69ZH9, Q8BNY7, Q9JJD6
      Conserved Domains (4) summary
      PHA03247
      Location:77479
      PHA03247; large tegument protein UL36; Provisional
      cd00992
      Location:457
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd04395
      Location:721916
      RhoGAP_ARHGAP21; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP21-like proteins. ArhGAP21 is a multi-domain protein, containing RhoGAP, PH and PDZ domains, and is believed to play a role in the organization of the cell-cell junction ...
      cl17171
      Location:496629
      PH-like; Pleckstrin homology-like domain
    11. XM_030246201.2XP_030102061.1  rho GTPase-activating protein 23 isoform X7

      UniProtKB/Swiss-Prot
      Q69ZH9, Q8BNY7, Q9JJD6
      Conserved Domains (3) summary
      PHA03247
      Location:20422
      PHA03247; large tegument protein UL36; Provisional
      cd04395
      Location:747942
      RhoGAP_ARHGAP21; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP21-like proteins. ArhGAP21 is a multi-domain protein, containing RhoGAP, PH and PDZ domains, and is believed to play a role in the organization of the cell-cell junction ...
      cd01253
      Location:535655
      PH_ARHGAP21-like; ARHGAP21 and related proteins pleckstrin homology (PH) domain
    12. XM_006533871.5XP_006533934.1  rho GTPase-activating protein 23 isoform X9

      UniProtKB/Swiss-Prot
      Q69ZH9, Q8BNY7, Q9JJD6
      Conserved Domains (3) summary
      PHA03307
      Location:3281
      PHA03307; transcriptional regulator ICP4; Provisional
      cd04395
      Location:692887
      RhoGAP_ARHGAP21; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP21-like proteins. ArhGAP21 is a multi-domain protein, containing RhoGAP, PH and PDZ domains, and is believed to play a role in the organization of the cell-cell junction ...
      cd01253
      Location:480600
      PH_ARHGAP21-like; ARHGAP21 and related proteins pleckstrin homology (PH) domain
    13. XM_006533874.4XP_006533937.1  rho GTPase-activating protein 23 isoform X10

      Conserved Domains (2) summary
      cd04395
      Location:107302
      RhoGAP_ARHGAP21; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP21-like proteins. ArhGAP21 is a multi-domain protein, containing RhoGAP, PH and PDZ domains, and is believed to play a role in the organization of the cell-cell junction ...
      cl17171
      Location:115
      PH-like; Pleckstrin homology-like domain
    14. XM_036156874.1XP_036012767.1  rho GTPase-activating protein 23 isoform X11

      Conserved Domains (2) summary
      cd04395
      Location:107302
      RhoGAP_ARHGAP21; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP21-like proteins. ArhGAP21 is a multi-domain protein, containing RhoGAP, PH and PDZ domains, and is believed to play a role in the organization of the cell-cell junction ...
      cl17171
      Location:115
      PH-like; Pleckstrin homology-like domain