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    Clspn claspin [ Mus musculus (house mouse) ]

    Gene ID: 269582, updated on 9-Dec-2024

    Summary

    Official Symbol
    Clspnprovided by MGI
    Official Full Name
    claspinprovided by MGI
    Primary source
    MGI:MGI:2445153
    See related
    Ensembl:ENSMUSG00000042489 AllianceGenome:MGI:2445153
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    B130025E01; E130314M08Rik
    Summary
    Predicted to enable DNA secondary structure binding activity and anaphase-promoting complex binding activity. Predicted to be involved in activation of protein kinase activity; mitotic G2/M transition checkpoint; and peptidyl-serine phosphorylation. Predicted to be located in Golgi apparatus and nucleoplasm. Is expressed in several structures, including alimentary system; brain ventricular layer; endocrine gland; genitourinary system; and immune system. Orthologous to human CLSPN (claspin). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in CNS E11.5 (RPKM 13.6), liver E14 (RPKM 12.3) and 10 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Clspn in Genome Data Viewer
    Location:
    4 D2.2; 4 60.9 cM
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (126450738..126488326)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (126556957..126594533)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene argonaute RISC catalytic subunit 1 Neighboring gene STARR-seq mESC enhancer starr_11403 Neighboring gene STARR-positive B cell enhancer ABC_E2714 Neighboring gene STARR-seq mESC enhancer starr_11404 Neighboring gene argonaute RISC catalytic subunit 4 Neighboring gene STARR-positive B cell enhancer ABC_E1655 Neighboring gene STARR-positive B cell enhancer mm9_chr4:126231790-126232090 Neighboring gene STARR-positive B cell enhancer ABC_E10259 Neighboring gene microRNA 7119 Neighboring gene STARR-seq mESC enhancer starr_11405 Neighboring gene 60S ribosomal protein L36a-like Neighboring gene RIKEN cDNA 5730409E04Rik gene Neighboring gene predicted gene, 46870

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA secondary structure binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables anaphase-promoting complex binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables anaphase-promoting complex binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables anaphase-promoting complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in DNA damage checkpoint signaling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in DNA repair IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of DNA replication checkpoint signaling ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within DNA replication checkpoint signaling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in activation of protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in mitotic DNA replication checkpoint signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in mitotic DNA replication checkpoint signaling IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in mitotic DNA replication checkpoint signaling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in mitotic G2 DNA damage checkpoint signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in mitotic G2 DNA damage checkpoint signaling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in mitotic G2 DNA damage checkpoint signaling ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in peptidyl-serine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    claspin
    Names
    claspin homolog

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001405798.1NP_001392727.1  claspin isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL606935
    2. NM_001405799.1NP_001392728.1  claspin isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL606935
    3. NM_001405800.1NP_001392729.1  claspin isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL606935
    4. NM_001405801.1NP_001392730.1  claspin isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL606935
    5. NM_175554.5NP_780763.3  claspin isoform 4

      See identical proteins and their annotated locations for NP_780763.3

      Status: VALIDATED

      Source sequence(s)
      AL606935
      Consensus CDS
      CCDS18655.1
      UniProtKB/Swiss-Prot
      B1ARX6, Q69GM2, Q80YR7
      Related
      ENSMUSP00000045344.9, ENSMUST00000048391.15

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      126450738..126488326
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006503124.4XP_006503187.1  claspin isoform X1

      See identical proteins and their annotated locations for XP_006503187.1

    2. XM_011240541.4XP_011238843.1  claspin isoform X3

      See identical proteins and their annotated locations for XP_011238843.1

      UniProtKB/Swiss-Prot
      B1ARX6, Q69GM2, Q80YR7
    3. XM_006503123.5XP_006503186.1  claspin isoform X1

      See identical proteins and their annotated locations for XP_006503186.1