U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Ptgr2 prostaglandin reductase 2 [ Mus musculus (house mouse) ]

    Gene ID: 77219, updated on 9-Dec-2024

    Summary

    Official Symbol
    Ptgr2provided by MGI
    Official Full Name
    prostaglandin reductase 2provided by MGI
    Primary source
    MGI:MGI:1916372
    See related
    Ensembl:ENSMUSG00000072946 AllianceGenome:MGI:1916372
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    PGR-2; PRG-2; Zadh1; 1810016I24Rik; 9130222H03Rik; 9630002F03Rik; B830026H24Rik
    Summary
    Predicted to enable 15-oxoprostaglandin 13-oxidase [NAD(P)+] activity. Predicted to be involved in prostaglandin metabolic process. Located in mitochondrion. Orthologous to human PTGR2 (prostaglandin reductase 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in heart adult (RPKM 20.2), kidney adult (RPKM 11.1) and 27 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Ptgr2 in Genome Data Viewer
    Location:
    12 D1; 12 39.14 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (84332011..84362606)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (84285237..84315832)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene mitotic deacetylase associated SANT domain protein Neighboring gene predicted gene, 46319 Neighboring gene STARR-seq mESC enhancer starr_32734 Neighboring gene ATP synthase, H+ transporting, mitochondrial F1 complex, O subunit pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E10765 Neighboring gene zinc finger protein 410 Neighboring gene LSM6 homolog, U6 small nuclear RNA associated pseudogene Neighboring gene family with sequence similarity 161, member B Neighboring gene STARR-positive B cell enhancer ABC_E1445 Neighboring gene coenzyme Q6 monooxygenase

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Gene trapped (1) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 15-oxoprostaglandin 13-oxidase [NAD(P)+] activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables 15-oxoprostaglandin 13-oxidase [NAD(P)+] activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables 15-oxoprostaglandin 13-oxidase [NAD(P)+] activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables 15-oxoprostaglandin 13-oxidase [NAD(P)+] activity TAS
    Traceable Author Statement
    more info
     
    NOT enables zinc ion binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in prostaglandin metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in prostaglandin metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in prostaglandin metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in mitochondrion HDA PubMed 

    General protein information

    Preferred Names
    prostaglandin reductase 2
    Names
    15-oxoprostaglandin 13-reductase
    zinc binding alcohol dehydrogenase, domain containing 1
    zinc-binding alcohol dehydrogenase domain-containing protein 1
    NP_001239554.1
    NP_001239555.1
    NP_084156.2
    XP_006516432.1
    XP_036013551.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001252625.1NP_001239554.1  prostaglandin reductase 2 isoform 1

      See identical proteins and their annotated locations for NP_001239554.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has an additional segment in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same isoform (1).
      Source sequence(s)
      AK145232, AK159932, CD742484, CJ050177
      Consensus CDS
      CCDS36490.1
      UniProtKB/Swiss-Prot
      Q3TG36, Q3ULY3, Q8BZA2, Q8VDQ1, Q9D1W8
      UniProtKB/TrEMBL
      Q3TXN1
      Related
      ENSMUSP00000119981.2, ENSMUST00000146377.8
      Conserved Domains (2) summary
      cd08293
      Location:1345
      PTGR2; Prostaglandin reductase
      COG2130
      Location:4347
      CurA; NADPH-dependent curcumin reductase CurA [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only]
    2. NM_001252626.1NP_001239555.1  prostaglandin reductase 2 isoform 2

      See identical proteins and their annotated locations for NP_001239555.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) has an additional exon in the 5' region, which includes an alternate AUG start codon, compared to variant 1. The resulting isoform (2) is shorter and has a distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      AK007522, AK168895, CD742484, CJ050177
      UniProtKB/TrEMBL
      Q3TXN1
      Conserved Domains (1) summary
      cd08293
      Location:2296
      PTGR2; Prostaglandin reductase
    3. NM_029880.3NP_084156.2  prostaglandin reductase 2 isoform 1

      See identical proteins and their annotated locations for NP_084156.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) is the predominant transcript and encodes the longer isoform (1). Variants 1 and 2 encode the same isoform.
      Source sequence(s)
      AK159932, CD742484, CJ050177
      Consensus CDS
      CCDS36490.1
      UniProtKB/Swiss-Prot
      Q3TG36, Q3ULY3, Q8BZA2, Q8VDQ1, Q9D1W8
      UniProtKB/TrEMBL
      Q3TXN1
      Related
      ENSMUSP00000115704.2, ENSMUST00000123614.8
      Conserved Domains (2) summary
      cd08293
      Location:1345
      PTGR2; Prostaglandin reductase
      COG2130
      Location:4347
      CurA; NADPH-dependent curcumin reductase CurA [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      84332011..84362606
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006516369.1XP_006516432.1  prostaglandin reductase 2 isoform X1

      UniProtKB/TrEMBL
      Q3TXN1
      Conserved Domains (1) summary
      cl16912
      Location:1288
      MDR; Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family
    2. XM_036157658.1XP_036013551.1  prostaglandin reductase 2 isoform X2

      Conserved Domains (1) summary
      cl16912
      Location:2239
      MDR; Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family