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    Macc1 metastasis associated in colon cancer 1 [ Mus musculus (house mouse) ]

    Gene ID: 238455, updated on 9-Dec-2024

    Summary

    Official Symbol
    Macc1provided by MGI
    Official Full Name
    metastasis associated in colon cancer 1provided by MGI
    Primary source
    MGI:MGI:2685113
    See related
    Ensembl:ENSMUSG00000041886 AllianceGenome:MGI:2685113
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm267; 4732474O15Rik
    Summary
    Predicted to be involved in positive regulation of transcription by RNA polymerase II. Predicted to be located in mitochondrion. Predicted to be active in cytoplasm. Is expressed in epithelium of phallic urethra of male and urethral plate. Orthologous to human MACC1 (MET transcriptional regulator MACC1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in bladder adult (RPKM 1.7), limb E14.5 (RPKM 0.3) and 5 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Macc1 in Genome Data Viewer
    Location:
    12 F2; 12 63.48 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (119354133..119430669)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (119390398..119466934)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 46331 Neighboring gene PRA1 domain family 2 pseudogene Neighboring gene STARR-seq mESC enhancer starr_33457 Neighboring gene NOP2 nucleolar protein homolog pseudogene Neighboring gene STARR-seq mESC enhancer starr_33458 Neighboring gene STARR-seq mESC enhancer starr_33459 Neighboring gene STARR-seq mESC enhancer starr_33460 Neighboring gene STARR-seq mESC enhancer starr_33461 Neighboring gene 60S ribosomal protein L5 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 

    General protein information

    Preferred Names
    metastasis-associated in colon cancer protein 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001163136.1NP_001156608.1  metastasis-associated in colon cancer protein 1

      See identical proteins and their annotated locations for NP_001156608.1

      Status: VALIDATED

      Source sequence(s)
      AC132596, AC138307
      Consensus CDS
      CCDS49199.1
      UniProtKB/TrEMBL
      E9PXX8
      Related
      ENSMUSP00000042955.7, ENSMUST00000048880.7
      Conserved Domains (2) summary
      pfam07653
      Location:552616
      SH3_2; Variant SH3 domain
      cl02517
      Location:219290
      ZU5; ZU5 domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      119354133..119430669
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006515863.3XP_006515926.1  metastasis-associated in colon cancer protein 1 isoform X2

      See identical proteins and their annotated locations for XP_006515926.1

      UniProtKB/TrEMBL
      E9PXX8
      Conserved Domains (2) summary
      pfam07653
      Location:552616
      SH3_2; Variant SH3 domain
      cl02517
      Location:219290
      ZU5; ZU5 domain
    2. XM_006515861.4XP_006515924.1  metastasis-associated in colon cancer protein 1 isoform X1

      Conserved Domains (2) summary
      pfam07653
      Location:562626
      SH3_2; Variant SH3 domain
      cl02517
      Location:229300
      ZU5; ZU5 domain
    3. XM_006515862.2XP_006515925.1  metastasis-associated in colon cancer protein 1 isoform X2

      See identical proteins and their annotated locations for XP_006515925.1

      UniProtKB/TrEMBL
      E9PXX8
      Related
      ENSMUSP00000152123.2, ENSMUST00000222058.2
      Conserved Domains (2) summary
      pfam07653
      Location:552616
      SH3_2; Variant SH3 domain
      cl02517
      Location:219290
      ZU5; ZU5 domain