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    Cndp1 carnosine dipeptidase 1 [ Mus musculus (house mouse) ]

    Gene ID: 338403, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cndp1provided by MGI
    Official Full Name
    carnosine dipeptidase 1provided by MGI
    Primary source
    MGI:MGI:2451097
    See related
    Ensembl:ENSMUSG00000056162 AllianceGenome:MGI:2451097
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Cn1
    Summary
    Enables dipeptidase activity. Acts upstream of or within proteolysis and regulation of protein metabolic process. Located in cytosol. Is expressed in alimentary system; genitourinary system; integumental system; sensory organ; and tail. Human ortholog(s) of this gene implicated in glomerulonephritis. Orthologous to human CNDP1 (carnosine dipeptidase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in kidney adult (RPKM 4.5), genital fat pad adult (RPKM 2.9) and 6 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Cndp1 in Genome Data Viewer
    Location:
    18 E4; 18 57.53 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (84628509..84668359, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (84610384..84650234, complement)

    Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene zinc finger protein 407 Neighboring gene STARR-seq mESC enhancer starr_45247 Neighboring gene predicted gene, 57824 Neighboring gene STARR-seq mESC enhancer starr_45248 Neighboring gene STARR-positive B cell enhancer mm9_chr18:84524711-84525012 Neighboring gene STARR-positive B cell enhancer mm9_chr18:84554442-84554743 Neighboring gene STARR-seq mESC enhancer starr_45250 Neighboring gene predicted gene, 31909 Neighboring gene STARR-seq mESC enhancer starr_45251 Neighboring gene STARR-seq mESC enhancer starr_45252 Neighboring gene STARR-seq mESC enhancer starr_45253 Neighboring gene STARR-positive B cell enhancer ABC_E1964 Neighboring gene nucleophosmin 1 pseudogene Neighboring gene CNDP dipeptidase 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Anserine and Carnosine Induce HSP70-Dependent H(2)S Formation in Endothelial Cells and Murine Kidney. Wetzel C, et al. Antioxidants (Basel), 2022 Dec 28. PMID 36670928, Free PMC Article
    2. A Global Cndp1-Knock-Out Selectively Increases Renal Carnosine and Anserine Concentrations in an Age- and Gender-Specific Manner in Mice. Weigand T, et al. Int J Mol Sci, 2020 Jul 10. PMID 32664451, Free PMC Article
    3. Carnosinase-1 Knock-Out Reduces Kidney Fibrosis in Type-1 Diabetic Mice on High Fat Diet. Pfeffer T, et al. Antioxidants (Basel), 2023 Jun 14. PMID 37372000, Free PMC Article
    4. Prenatal differentiation of mouse vomeronasal neurones. Tarozzo G, et al. Eur J Neurosci, 1998 Jan. PMID 9753148
    5. Sequence identification and characterization of human carnosinase and a closely related non-specific dipeptidase. Teufel M, et al. J Biol Chem, 2003 Feb 21. PMID 12473676

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (1)  1 citation

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables carboxypeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables dipeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables dipeptidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables dipeptidase activity ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metallodipeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within proteolysis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within proteolysis ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of protein metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of protein metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    beta-Ala-His dipeptidase
    Names
    CNDP dipeptidase 1
    carnosinase 1
    carnosine dipeptidase 1 (metallopeptidase M20 family)
    NP_803233.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_177450.4 → NP_803233.2  beta-Ala-His dipeptidase

      See identical proteins and their annotated locations for NP_803233.2

      Status: VALIDATED

      Source sequence(s)
      AK085308, AK162089, AK165706, BB499598, BY006586
      Consensus CDS
      CCDS29382.1
      UniProtKB/Swiss-Prot
      Q80XP5, Q8BUG2
      UniProtKB/TrEMBL
      A0A0R4J0V0
      Related
      ENSMUSP00000069699.8, ENSMUST00000070139.9
      Conserved Domains (2) summary
      PRK08201
      Location:16 → 479
      PRK08201; hypothetical protein; Provisional
      cd05676
      Location:13 → 480
      M20_dipept_like_CNDP; M20 cytosolic nonspecific dipeptidases including anserinase and serum carnosinase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000084.7 Reference GRCm39 C57BL/6J

      Range
      84628509..84668359 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_386374.3 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BUG2.1 GenPept UniProtKB/Swiss-Prot:Q8BUG2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
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