U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Mtdh metadherin [ Mus musculus (house mouse) ]

    Gene ID: 67154, updated on 9-Dec-2024

    Summary

    Official Symbol
    Mtdhprovided by MGI
    Official Full Name
    metadherinprovided by MGI
    Primary source
    MGI:MGI:1914404
    See related
    Ensembl:ENSMUSG00000022255 AllianceGenome:MGI:1914404
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    3D3; AEG-1; Lyric; 3D3/Lyric; D8Bwg1112e; 2610103J23Rik
    Summary
    Predicted to enable NF-kappaB binding activity; double-stranded RNA binding activity; and transcription coactivator activity. Predicted to be involved in several processes, including lipopolysaccharide-mediated signaling pathway; positive regulation of intracellular signal transduction; and regulation of DNA-templated transcription. Located in endoplasmic reticulum membrane; nucleolus; and perinuclear region of cytoplasm. Is expressed in several structures, including brain; genitourinary system; limb primordium; nose; and skin. Human ortholog(s) of this gene implicated in hepatocellular carcinoma. Orthologous to human MTDH (metadherin). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 15.3), bladder adult (RPKM 13.4) and 28 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Mtdh in Genome Data Viewer
    Location:
    15 B3.1; 15 13.98 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (34082613..34143683)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (34082442..34143537)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_38315 Neighboring gene predicted gene 9643 Neighboring gene predicted gene, 41290 Neighboring gene STARR-positive B cell enhancer ABC_E8585 Neighboring gene STARR-positive B cell enhancer ABC_E9909 Neighboring gene STARR-positive B cell enhancer ABC_E10848 Neighboring gene STARR-seq mESC enhancer starr_38319 Neighboring gene STARR-seq mESC enhancer starr_38320 Neighboring gene predicted gene, 41291 Neighboring gene predicted gene, 38594 Neighboring gene STARR-seq mESC enhancer starr_38323 Neighboring gene STARR-seq mESC enhancer starr_38324 Neighboring gene CapStarr-seq enhancer MGSCv37_chr15:34167683-34167792 Neighboring gene STARR-seq mESC enhancer starr_38325 Neighboring gene lysosomal-associated protein transmembrane 4B Neighboring gene eukaryotic translation initiation factor 4A2 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables NF-kappaB binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables NF-kappaB binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables NF-kappaB binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables RNA polymerase II-specific DNA-binding transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables double-stranded RNA binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables transcription coactivator activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables transcription coactivator activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables transcription coregulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in lipopolysaccharide-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in lipopolysaccharide-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of transcription by RNA polymerase II ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of NF-kappaB transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of NF-kappaB transcription factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of angiogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of angiogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of autophagy IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of autophagy ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of canonical NF-kappaB signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of canonical NF-kappaB signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in apical plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in bicellular tight junction IEA
    Inferred from Electronic Annotation
    more info
     
    located_in bicellular tight junction ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endoplasmic reticulum ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in endoplasmic reticulum membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in fibrillar center IEA
    Inferred from Electronic Annotation
    more info
     
    located_in fibrillar center ISO
    Inferred from Sequence Orthology
    more info
     
    located_in intercellular canaliculus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nuclear body IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nuclear membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in perinuclear region of cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    protein LYRIC
    Names
    lysine-rich CEACAM1 co-isolated protein
    metastasis adhesion protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001357925.1NP_001344854.1  protein LYRIC isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks exons in the coding region, compared to variant 1. The encoded isoform (2) is shorter, compared to isoform 1.
      Source sequence(s)
      AC149588
      Conserved Domains (1) summary
      pfam15686
      Location:6386
      LYRIC; Lysine-rich CEACAM1 co-isolated protein family
    2. NM_001357926.1NP_001344855.1  protein LYRIC isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AC149588
      Conserved Domains (1) summary
      pfam15686
      Location:6449
      LYRIC; Lysine-rich CEACAM1 co-isolated protein family
    3. NM_026002.5NP_080278.3  protein LYRIC isoform 3

      See identical proteins and their annotated locations for NP_080278.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an exon in the coding region, compared to variant 1. The encoded isoform (3) is shorter, compared to isoform 1.
      Source sequence(s)
      AC149588
      Consensus CDS
      CCDS27415.1
      UniProtKB/Swiss-Prot
      B2RSG8, Q05CM0, Q3U9F8, Q3UAQ8, Q80WJ7, Q8BN67, Q8CBT9, Q8CDL0, Q8CGI7, Q9D052
      Related
      ENSMUSP00000022865.10, ENSMUST00000022865.17
      Conserved Domains (1) summary
      pfam15686
      Location:6419
      LYRIC; Lysine-rich CEACAM1 co-isolated protein family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      34082613..34143683
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006520151.3XP_006520214.1  protein LYRIC isoform X2

      Conserved Domains (1) summary
      pfam15686
      Location:6449
      LYRIC; Lysine-rich CEACAM1 co-isolated protein family
    2. XM_017316729.3XP_017172218.1  protein LYRIC isoform X4

      Conserved Domains (1) summary
      pfam15686
      Location:6419
      LYRIC; Lysine-rich CEACAM1 co-isolated protein family
    3. XM_006520152.3XP_006520215.1  protein LYRIC isoform X7

      UniProtKB/TrEMBL
      F6QHD1
      Related
      ENSMUSP00000130190.3, ENSMUST00000163333.9
      Conserved Domains (1) summary
      pfam15686
      Location:6386
      LYRIC; Lysine-rich CEACAM1 co-isolated protein family
    4. XM_006520149.3XP_006520212.1  protein LYRIC isoform X1

      Conserved Domains (1) summary
      pfam15686
      Location:6390
      LYRIC; Lysine-rich CEACAM1 co-isolated protein family
    5. XM_017316731.3XP_017172220.1  protein LYRIC isoform X6

      Conserved Domains (1) summary
      pfam15686
      Location:6390
      LYRIC; Lysine-rich CEACAM1 co-isolated protein family
    6. XM_017316728.3XP_017172217.1  protein LYRIC isoform X3

      Conserved Domains (1) summary
      pfam15686
      Location:6360
      LYRIC; Lysine-rich CEACAM1 co-isolated protein family
    7. XM_017316730.3XP_017172219.1  protein LYRIC isoform X5

      Conserved Domains (1) summary
      pfam15686
      Location:6327
      LYRIC; Lysine-rich CEACAM1 co-isolated protein family
    8. XM_030248710.1XP_030104570.1  protein LYRIC isoform X8

      UniProtKB/TrEMBL
      F6ZSG0
      Related
      ENSMUSP00000131814.2, ENSMUST00000169905.2
      Conserved Domains (1) summary
      pfam15686
      Location:12208
      LYRIC; Lysine-rich CEACAM1 co-isolated protein family
    9. XM_036159548.1XP_036015441.1  protein LYRIC isoform X9

      UniProtKB/TrEMBL
      F6ZSG0
      Conserved Domains (1) summary
      pfam15686
      Location:12175
      LYRIC; Lysine-rich CEACAM1 co-isolated protein family