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    Cyp2j9 cytochrome P450, family 2, subfamily j, polypeptide 9 [ Mus musculus (house mouse) ]

    Gene ID: 74519, updated on 3-Dec-2024

    Summary

    Official Symbol
    Cyp2j9provided by MGI
    Official Full Name
    cytochrome P450, family 2, subfamily j, polypeptide 9provided by MGI
    Primary source
    MGI:MGI:1921769
    See related
    Ensembl:ENSMUSG00000015224 AllianceGenome:MGI:1921769
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    8430417E17Rik
    Summary
    Predicted to enable heme binding activity; isomerase activity; and monooxygenase activity. Predicted to be involved in epoxygenase P450 pathway; linoleic acid metabolic process; and xenobiotic metabolic process. Located in endoplasmic reticulum. Is expressed in alimentary system; ductus arteriosus; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in hypertension; myocardial infarction; pulmonary hypertension; renal fibrosis; and renal hypertension. Orthologous to human CYP2J2 (cytochrome P450 family 2 subfamily J member 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in cerebellum adult (RPKM 8.9), cortex adult (RPKM 7.7) and 20 other tissues See more
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    Genomic context

    See Cyp2j9 in Genome Data Viewer
    Location:
    4 C5; 4 44.66 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (96456661..96480748, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (96568424..96592523, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_10825 Neighboring gene cytochrome P450, family 2, subfamily j, polypeptide 8 Neighboring gene cytochrome P450, family 2, subfamily j, polypeptide 6 Neighboring gene STARR-seq mESC enhancer starr_10826 Neighboring gene cytochrome P450, family 2, subfamily j, polypeptide 5 Neighboring gene predicted gene 12695

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

    Markers

    Clone Names

    • MGC141274

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in epoxygenase P450 pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in icosanoid metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in linoleic acid metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in organic acid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in xenobiotic metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in intracellular membrane-bounded organelle IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    cytochrome P450, family 2, subfamily j, polypeptide 9
    Names
    cytochrome P450, 2j9

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001419233.1NP_001406162.1  cytochrome P450, family 2, subfamily j, polypeptide 9 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL683816
      Related
      ENSMUST00000126509.2
    2. NM_001419234.1NP_001406163.1  cytochrome P450, family 2, subfamily j, polypeptide 9 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AL683816
    3. NM_001419236.1NP_001406165.1  cytochrome P450, family 2, subfamily j, polypeptide 9 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL683816
      UniProtKB/TrEMBL
      Q9CRQ9
    4. NM_028979.3NP_083255.1  cytochrome P450, family 2, subfamily j, polypeptide 9 isoform 1

      See identical proteins and their annotated locations for NP_083255.1

      Status: VALIDATED

      Source sequence(s)
      AL683816
      Consensus CDS
      CCDS18370.1
      UniProtKB/TrEMBL
      Q924D1, Q9CRQ9
      Related
      ENSMUSP00000050464.9, ENSMUST00000055693.9
      Conserved Domains (1) summary
      pfam00067
      Location:44497
      p450; Cytochrome P450

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      96456661..96480748 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030253853.2XP_030109713.1  cytochrome P450, family 2, subfamily j, polypeptide 9 isoform X1

      UniProtKB/TrEMBL
      Q9CRQ9
      Conserved Domains (1) summary
      pfam00067
      Location:32440
      p450; Cytochrome P450