Dlgap1 DLG associated protein 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Dlgap1provided by MGI
Official Full Name: DLG associated protein 1provided by MGI
Primary source: MGI:MGI:1346065
See related: Ensembl:ENSMUSG00000003279 AllianceGenome:MGI:1346065
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Gkap; Sapap1; mKIAA4162; 9630002F18; GKAP/SAPAP; GKPA/SAPAP; D17Bwg0511e; 4933422O14Rik
Summary: Predicted to enable molecular adaptor activity and protein domain specific binding activity. Predicted to be a structural constituent of postsynaptic density. Predicted to be involved in several processes, including aggresome assembly; protein localization to synapse; and regulation of proteasomal protein catabolic process. Predicted to act upstream of or within chemical synaptic transmission. Located in postsynaptic density. Is expressed in cortical plate and hippocampus. Orthologous to human DLGAP1 (DLG associated protein 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in frontal lobe adult (RPKM 40.8), cortex adult (RPKM 32.3) and 6 other tissues See more
Orthologs: human all
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Genomic context

Location:: 17 E1.3; 17 40.85 cM

Exon count:: 22

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (70276068..71128408)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17	NC_000083.6 (69969073..70821413)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Learning and reaction times in mouse touchscreen tests are differentially impacted by mutations in genes encoding postsynaptic interacting proteins SYNGAP1, NLGN3, DLGAP1, DLGAP2 and SHANK2.
Title: Learning and reaction times in mouse touchscreen tests are differentially impacted by mutations in genes encoding postsynaptic interacting proteins SYNGAP1, NLGN3, DLGAP1, DLGAP2 and SHANK2.
Dlgap1 negatively regulates browning of white fat cells through effects on cell proliferation and apoptosis.
Title: Dlgap1 negatively regulates browning of white fat cells through effects on cell proliferation and apoptosis.
These data suggest that Dlgap1 knockout leads to post-synaptic density disruption and reduced sociability, consistent with reports of DLGAP1 haploinsufficient variants in schizophrenia and autism spectrum disorder.
Title: Dlgap1 knockout mice exhibit alterations of the postsynaptic density and selective reductions in sociability.
GKAP-DLC2 interaction organizes the postsynaptic scaffold complex to enhance synaptic NMDA receptor activity.
Title: GKAP-DLC2 interaction organizes the postsynaptic scaffold complex to enhance synaptic NMDA receptor activity.
Expression of Dlgap1 in the mouse prefrontal cortex is modulated by a sequence variant (B2 SINE indel) in the 3' UTR of Comt (catechol-O-methyltransferase).
Title: A transposon in Comt generates mRNA variants and causes widespread expression and behavioral differences among mice.
Semi-quantitative analysis of RNA levels in FMRP immunoprecipitates showed that in the mouse brain mRNAs encoding PSD components, such as Shank1, SAPAP1-3, PSD-95, and the glutamate receptor subunits NR1 and NR2B, are associated with FMRP.
Title: Fragile X mental retardation protein regulates the levels of scaffold proteins and glutamate receptors in postsynaptic densities.
the loss of the SH3, protein 4.1 and/or GUK domains of Dlg1 disrupt epithelial polarity and perturb nephrogenesis either as a secondary consequence to a defect in ureteric branching morphogenesis and/or delay in mesenchyme-to- epithelial transition
Title: Mutagenesis of the epithelial polarity gene, discs large 1, perturbs nephrogenesis in the developing mouse kidney.
results suggest that inactivation of Dlg1 augments HTLV-1 Tax-mediated transformation of the T-cell line (CTLL-2)
Title: Inactivation of tumor suppressor Dlg1 augments transformation of a T-cell line induced by human T-cell leukemia virus type 1 Tax protein.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

BB075781 (e-PCR)
- UniSTS:186114

D17Bwg0511e (e-PCR), detects polymorphism
- UniSTS:142111

AI848168 (e-PCR)
- UniSTS:181060

AI845682 (e-PCR)
- UniSTS:166069

D17Mit160 (e-PCR), detects polymorphism
- UniSTS:127986

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables molecular adaptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein domain specific binding	ISO Inferred from Sequence Orthology more info
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info
enables protein-containing complex binding	ISS Inferred from Sequence or Structural Similarity more info
enables structural constituent of postsynaptic density	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in aggresome assembly	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within chemical synaptic transmission	TAS Traceable Author Statement more info	PubMed
involved_in modulation of chemical synaptic transmission	IBA Inferred from Biological aspect of Ancestor more info
involved_in modulation of chemical synaptic transmission	ISO Inferred from Sequence Orthology more info
involved_in protein localization to synapse	ISO Inferred from Sequence Orthology more info
involved_in regulation of proteasomal protein catabolic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in glutamatergic synapse	IBA Inferred from Biological aspect of Ancestor more info
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in postsynaptic density	IDA Inferred from Direct Assay more info	PubMed
located_in postsynaptic density	IMP Inferred from Mutant Phenotype more info	PubMed
located_in postsynaptic density	ISO Inferred from Sequence Orthology more info
is_active_in postsynaptic density, intracellular component	ISO Inferred from Sequence Orthology more info
located_in postsynaptic membrane	ISO Inferred from Sequence Orthology more info
is_active_in postsynaptic specialization	IBA Inferred from Biological aspect of Ancestor more info
located_in synapse	IDA Inferred from Direct Assay more info	PubMed
located_in synapse	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: disks large-associated protein 1

Names: DAP-1 beta; PSD-95/SAP90-binding protein 1; SAP90/PSD-95 associated protein 1; discs, large homolog-associated protein 1; guanylate kinase-associated protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001128180.1 → NP_001121652.1 disks large-associated protein 1 isoform 3

Status: VALIDATED

Description

Transcript Variant: This variant (3) has multiple differences in the coding region but maintains the reading frame, compared to variant 1. It encodes isoform 3 which is shorter and has a distinct N-terminus, compared to isoform 1.

Source sequence(s)

AC079441, AC154769, AC163902

Consensus CDS

CCDS50172.1

UniProtKB/TrEMBL

E9QAR5, Q3TSN1

Related

ENSMUSP00000122337.2, ENSMUST00000148486.8

Conserved Domains (1) summary

pfam03359
Location:350 → 682

GKAP; Guanylate-kinase-associated protein (GKAP) protein
NM_001128181.1 → NP_001121653.1 disks large-associated protein 1 isoform 4

See identical proteins and their annotated locations for NP_001121653.1

Status: VALIDATED

Description

Transcript Variant: This variant (4) includes alternate exons in the 5' and 3' ends of the coding region but maintains the reading frame, compared to variant 1. It encodes isoform 4 which is shorter and has distinct N- and C-termini, compared to isoform 1.

Source sequence(s)

AC079441, AC163902

Consensus CDS

CCDS50173.1

UniProtKB/TrEMBL

A0A3B2W7Z1, Q3UVU8

Related

ENSMUSP00000094890.3, ENSMUST00000097288.4

Conserved Domains (1) summary

pfam03359
Location:352 → 618

GKAP; Guanylate-kinase-associated protein (GKAP) protein
NM_001347411.1 → NP_001334340.1 disks large-associated protein 1 isoform 5

Status: VALIDATED

Source sequence(s)

AC079441, AC154604, AC154769, AC163902, AC165424, AI837331

Consensus CDS

CCDS84331.1

UniProtKB/TrEMBL

D3Z709

Related

ENSMUSP00000118497.2, ENSMUST00000135938.8
NM_001347412.1 → NP_001334341.1 disks large-associated protein 1 isoform 6

Status: VALIDATED

Source sequence(s)

AC079441, AC154604, AC154769, AC163902, AC165424, AI837331

Consensus CDS

CCDS84332.1

UniProtKB/TrEMBL

D3Z709, Q3UHD8

Related

ENSMUSP00000116716.2, ENSMUST00000133983.8

Conserved Domains (1) summary

pfam03359
Location:650 → 982

GKAP; Guanylate-kinase-associated protein (GKAP) protein
NM_001347413.1 → NP_001334342.1 disks large-associated protein 1 isoform 7

Status: VALIDATED

Source sequence(s)

AC079441, AC154769, AC163902, AI837331

Consensus CDS

CCDS84333.1

UniProtKB/TrEMBL

D3Z508, Q3TSN1

Related

ENSMUSP00000117358.2, ENSMUST00000140728.8
NM_001347414.1 → NP_001334343.1 disks large-associated protein 1 isoform 8

Status: VALIDATED

Source sequence(s)

AC079441, AC154769, AC163902, AI837331

Consensus CDS

CCDS84334.1

UniProtKB/TrEMBL

D3Z6F4, Q3TSN1

Related

ENSMUSP00000122370.2, ENSMUST00000133717.9
NM_001360665.1 → NP_001347594.1 disks large-associated protein 1 isoform 6

Status: VALIDATED

Source sequence(s)

AC079441, AC154604, AC154769, AC163902, AC165424, AC168117

Consensus CDS

CCDS84332.1

UniProtKB/TrEMBL

D3Z709, Q3UHD8

Related

ENSMUSP00000052858.6, ENSMUST00000060072.12

Conserved Domains (1) summary

pfam03359
Location:650 → 982

GKAP; Guanylate-kinase-associated protein (GKAP) protein
NM_027712.3 → NP_081988.3 disks large-associated protein 1 isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) has multiple differences in the coding region but maintains the reading frame, compared to variant 1. It encodes isoform 2 which is shorter and has a distinct C-terminus, compared to isoform 1.

Source sequence(s)

AC154769, BC094369

UniProtKB/TrEMBL

D3Z709

Related

ENSMUSP00000116072.2, ENSMUST00000146730.9

Conserved Domains (1) summary

pfam03359
Location:650 → 916

GKAP; Guanylate-kinase-associated protein (GKAP) protein
NM_177639.6 → NP_808307.2 disks large-associated protein 1 isoform 1

See identical proteins and their annotated locations for NP_808307.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).

Source sequence(s)

AC079441, AC154769, AC163902

Consensus CDS

CCDS28953.1

UniProtKB/Swiss-Prot

Q52KF6, Q5DTK5, Q6P6N4, Q6XBF4, Q8BZL7, Q8BZQ1, Q8C0G0, Q9D415

UniProtKB/TrEMBL

D3Z709

Related

ENSMUSP00000122896.2, ENSMUST00000155016.8

Conserved Domains (1) summary

pfam03359
Location:660 → 992

GKAP; Guanylate-kinase-associated protein (GKAP) protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000083.7 Reference GRCm39 C57BL/6J

Range

70276068..71128408

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036160564.1 → XP_036016457.1 disks large-associated protein 1 isoform X6

UniProtKB/TrEMBL

D3Z709, Q3UHD8

Conserved Domains (1) summary

pfam03359
Location:650 → 982

GKAP; Guanylate-kinase-associated protein (GKAP) protein
XM_036160565.1 → XP_036016458.1 disks large-associated protein 1 isoform X7

UniProtKB/TrEMBL

D3Z709

Conserved Domains (1) summary

pfam03359
Location:622 → 954

GKAP; Guanylate-kinase-associated protein (GKAP) protein
XM_006524173.3 → XP_006524236.1 disks large-associated protein 1 isoform X4

See identical proteins and their annotated locations for XP_006524236.1

UniProtKB/Swiss-Prot

Q52KF6, Q5DTK5, Q6P6N4, Q6XBF4, Q8BZL7, Q8BZQ1, Q8C0G0, Q9D415

UniProtKB/TrEMBL

D3Z709

Conserved Domains (1) summary

pfam03359
Location:660 → 992

GKAP; Guanylate-kinase-associated protein (GKAP) protein
XM_036160562.1 → XP_036016455.1 disks large-associated protein 1 isoform X4

UniProtKB/Swiss-Prot

Q52KF6, Q5DTK5, Q6P6N4, Q6XBF4, Q8BZL7, Q8BZQ1, Q8C0G0, Q9D415

UniProtKB/TrEMBL

D3Z709

Conserved Domains (1) summary

pfam03359
Location:660 → 992

GKAP; Guanylate-kinase-associated protein (GKAP) protein
XM_011246406.3 → XP_011244708.1 disks large-associated protein 1 isoform X1

See identical proteins and their annotated locations for XP_011244708.1

UniProtKB/TrEMBL

D3Z709

Conserved Domains (1) summary

pfam03359
Location:698 → 1030

GKAP; Guanylate-kinase-associated protein (GKAP) protein
XM_011246407.3 → XP_011244709.1 disks large-associated protein 1 isoform X4

See identical proteins and their annotated locations for XP_011244709.1

UniProtKB/Swiss-Prot

Q52KF6, Q5DTK5, Q6P6N4, Q6XBF4, Q8BZL7, Q8BZQ1, Q8C0G0, Q9D415

UniProtKB/TrEMBL

D3Z709

Conserved Domains (1) summary

pfam03359
Location:660 → 992

GKAP; Guanylate-kinase-associated protein (GKAP) protein
XM_006524169.3 → XP_006524232.1 disks large-associated protein 1 isoform X1

See identical proteins and their annotated locations for XP_006524232.1

UniProtKB/TrEMBL

D3Z709

Conserved Domains (1) summary

pfam03359
Location:698 → 1030

GKAP; Guanylate-kinase-associated protein (GKAP) protein
XM_030249738.1 → XP_030105598.1 disks large-associated protein 1 isoform X4

UniProtKB/Swiss-Prot

Q52KF6, Q5DTK5, Q6P6N4, Q6XBF4, Q8BZL7, Q8BZQ1, Q8C0G0, Q9D415

UniProtKB/TrEMBL

D3Z709

Conserved Domains (1) summary

pfam03359
Location:660 → 992

GKAP; Guanylate-kinase-associated protein (GKAP) protein
XM_036160563.1 → XP_036016456.1 disks large-associated protein 1 isoform X6

UniProtKB/TrEMBL

D3Z709, Q3UHD8

Conserved Domains (1) summary

pfam03359
Location:650 → 982

GKAP; Guanylate-kinase-associated protein (GKAP) protein
XM_006524168.3 → XP_006524231.1 disks large-associated protein 1 isoform X1

See identical proteins and their annotated locations for XP_006524231.1

UniProtKB/TrEMBL

D3Z709

Conserved Domains (1) summary

pfam03359
Location:698 → 1030

GKAP; Guanylate-kinase-associated protein (GKAP) protein
XM_006524172.3 → XP_006524235.1 disks large-associated protein 1 isoform X3

UniProtKB/TrEMBL

D3Z709

Conserved Domains (1) summary

pfam03359
Location:670 → 1002

GKAP; Guanylate-kinase-associated protein (GKAP) protein
XM_006524171.3 → XP_006524234.1 disks large-associated protein 1 isoform X2

UniProtKB/TrEMBL

D3Z709

Conserved Domains (1) summary

pfam03359
Location:688 → 1020

GKAP; Guanylate-kinase-associated protein (GKAP) protein
XM_006524174.3 → XP_006524237.1 disks large-associated protein 1 isoform X5

UniProtKB/TrEMBL

D3Z709

Conserved Domains (1) summary

pfam03359
Location:660 → 992

GKAP; Guanylate-kinase-associated protein (GKAP) protein
XM_006524177.5 → XP_006524240.3 disks large-associated protein 1 isoform X8

UniProtKB/TrEMBL

A0A3B2WD59

Conserved Domains (1) summary

pfam03359
Location:431 → 763

GKAP; Guanylate-kinase-associated protein (GKAP) protein
XM_006524178.5 → XP_006524241.3 disks large-associated protein 1 isoform X9

UniProtKB/TrEMBL

A0A3B2WD59

Conserved Domains (1) summary

pfam03359
Location:393 → 725

GKAP; Guanylate-kinase-associated protein (GKAP) protein
XM_030249741.2 → XP_030105601.2 disks large-associated protein 1 isoform X13

UniProtKB/TrEMBL

A0A3B2WD59

Conserved Domains (1) summary

pfam03359
Location:365 → 697

GKAP; Guanylate-kinase-associated protein (GKAP) protein
XM_030249739.2 → XP_030105599.2 disks large-associated protein 1 isoform X11

UniProtKB/TrEMBL

A0A3B2WD59

Conserved Domains (1) summary

pfam03359
Location:383 → 715

GKAP; Guanylate-kinase-associated protein (GKAP) protein
XM_006524183.5 → XP_006524246.3 disks large-associated protein 1 isoform X15

UniProtKB/TrEMBL

A0A3B2WD59

Related

ENSMUSP00000156863.2, ENSMUST00000233283.2

Conserved Domains (1) summary

pfam03359
Location:355 → 687

GKAP; Guanylate-kinase-associated protein (GKAP) protein
XM_017317449.2 → XP_017172938.1 disks large-associated protein 1 isoform X19

UniProtKB/TrEMBL

Q3TSN1

Conserved Domains (1) summary

pfam03359
Location:332 → 664

GKAP; Guanylate-kinase-associated protein (GKAP) protein
XM_017317450.2 → XP_017172939.1 disks large-associated protein 1 isoform X22

UniProtKB/TrEMBL

A0A3B2WD59

Conserved Domains (1) summary

pfam03359
Location:322 → 654

GKAP; Guanylate-kinase-associated protein (GKAP) protein
XM_006524181.1 → XP_006524244.1 disks large-associated protein 1 isoform X14

UniProtKB/TrEMBL

Q3TSN1

Conserved Domains (1) summary

pfam03359
Location:362 → 694

GKAP; Guanylate-kinase-associated protein (GKAP) protein
XM_006524185.1 → XP_006524248.1 disks large-associated protein 1 isoform X17

UniProtKB/TrEMBL

Q3TSN1

Conserved Domains (1) summary

pfam03359
Location:352 → 684

GKAP; Guanylate-kinase-associated protein (GKAP) protein
XM_036160566.1 → XP_036016459.1 disks large-associated protein 1 isoform X20

UniProtKB/TrEMBL

A0A3B2WD59

Conserved Domains (1) summary

pfam03359
Location:324 → 656

GKAP; Guanylate-kinase-associated protein (GKAP) protein
XM_006524184.4 → XP_006524247.1 disks large-associated protein 1 isoform X16

UniProtKB/TrEMBL

A0A3B2WD59

Conserved Domains (1) summary

pfam03359
Location:352 → 684

GKAP; Guanylate-kinase-associated protein (GKAP) protein
XM_036160567.1 → XP_036016460.1 disks large-associated protein 1 isoform X21

UniProtKB/TrEMBL

A0A3B2WD59

Conserved Domains (1) summary

pfam03359
Location:324 → 656

GKAP; Guanylate-kinase-associated protein (GKAP) protein
XM_030249742.1 → XP_030105602.1 disks large-associated protein 1 isoform X18

UniProtKB/TrEMBL

Q3TSN1

Conserved Domains (1) summary

pfam03359
Location:342 → 674

GKAP; Guanylate-kinase-associated protein (GKAP) protein
XM_006524179.5 → XP_006524242.1 disks large-associated protein 1 isoform X10

UniProtKB/TrEMBL

Q3TSN1

Conserved Domains (1) summary

pfam03359
Location:390 → 722

GKAP; Guanylate-kinase-associated protein (GKAP) protein
XM_006524180.2 → XP_006524243.2 disks large-associated protein 1 isoform X12

UniProtKB/TrEMBL

A0A3B2WD59

Conserved Domains (1) summary

pfam03359
Location:343 → 675

GKAP; Guanylate-kinase-associated protein (GKAP) protein