Slc35b4 solute carrier family 35, member B4 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Slc35b4provided by MGI
Official Full Name: solute carrier family 35, member B4provided by MGI
Primary source: MGI:MGI:1931249
See related: Ensembl:ENSMUSG00000018999 AllianceGenome:MGI:1931249
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 4930474D06Rik
Summary: Predicted to enable UDP-N-acetylglucosamine transmembrane transporter activity and UDP-xylose transmembrane transporter activity. Acts upstream of or within regulation of gluconeogenesis. Predicted to be located in Golgi apparatus and endoplasmic reticulum. Predicted to be active in Golgi membrane and endoplasmic reticulum membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Orthologous to human SLC35B4 (solute carrier family 35 member B4). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in kidney adult (RPKM 32.1), genital fat pad adult (RPKM 17.7) and 27 other tissues See more
Orthologs: human all
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Genomic context

Location:: 6 A3.3; 6 14.75 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (34132810..34153921, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (34155872..34177054, complement)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Decreased SLC35B4 expression led to increased gluconeogenesis in H2.35 cells.
Title: Deep congenic analysis identifies many strong, context-dependent QTLs, one of which, Slc35b4, regulates obesity and glucose homeostasis.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2)

General gene information

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Markers

D6Mit310 (e-PCR), detects polymorphism
- UniSTS:130862

NoName (e-PCR)
- UniSTS:235405

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables UDP-N-acetylglucosamine transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables UDP-N-acetylglucosamine transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables UDP-N-acetylglucosamine transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables UDP-xylose transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables UDP-xylose transmembrane transporter activity	ISO Inferred from Sequence Orthology more info	PubMed

Process	Evidence Code	Pubs
involved_in UDP-N-acetylglucosamine transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in UDP-N-acetylglucosamine transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in UDP-N-acetylglucosamine transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in UDP-xylose transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in UDP-xylose transmembrane transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of gluconeogenesis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in Golgi apparatus	ISO Inferred from Sequence Orthology more info	PubMed
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
is_active_in Golgi membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
is_active_in endoplasmic reticulum membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: nucleotide sugar transporter SLC35B4

Names: UDP-xylose and UDP-N-acetylglucosamine transporter

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.