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    Sppl2b signal peptide peptidase like 2B [ Mus musculus (house mouse) ]

    Gene ID: 73218, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Sppl2bprovided by MGI
    Official Full Name
    signal peptide peptidase like 2Bprovided by MGI
    Primary source
    MGI:MGI:1920468
    See related
    Ensembl:ENSMUSG00000035206 AllianceGenome:MGI:1920468
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    PSL1; 3110056O03Rik
    Summary
    Predicted to enable aspartic endopeptidase activity, intramembrane cleaving and protein homodimerization activity. Predicted to be involved in membrane protein ectodomain proteolysis; membrane protein intracellular domain proteolysis; and regulation of immune response. Predicted to be located in several cellular components, including cytoskeleton; endosome membrane; and nucleoplasm. Predicted to be active in bounding membrane of organelle and endoplasmic reticulum membrane. Is expressed in embryo. Orthologous to human SPPL2B (signal peptide peptidase like 2B). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in ovary adult (RPKM 48.2), testis adult (RPKM 46.6) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Sppl2b in Genome Data Viewer
    Location:
    10 C1; 10 39.72 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (80691067..80704542)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (80855242..80868708)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene leucine rich repeat and Ig domain containing 3 Neighboring gene STARR-positive B cell enhancer ABC_E11447 Neighboring gene STARR-positive B cell enhancer ABC_E6885 Neighboring gene LSM7 homolog, U6 small nuclear RNA and mRNA degradation associated Neighboring gene transmembrane protease, serine 9 Neighboring gene translocase of inner mitochondrial membrane 13 Neighboring gene lamin B2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The intramembrane proteases SPPL2a and SPPL2b regulate the homeostasis of selected SNARE proteins. Ballin M, et al. FEBS J, 2023 May. PMID 36047592
    2. The intramembrane proteases signal Peptide peptidase-like 2a and 2b have distinct functions in vivo. Schneppenheim J, et al. Mol Cell Biol, 2014 Apr. PMID 24492962, Free PMC Article
    3. Atherogenic LOX-1 signaling is controlled by SPPL2-mediated intramembrane proteolysis. Mentrup T, et al. J Exp Med, 2019 Apr 1. PMID 30819724, Free PMC Article
    4. Signal peptide peptidase-like 2b modulates the amyloidogenic pathway and exhibits an Aβ-dependent expression in Alzheimer's disease. Maccioni R, et al. Prog Neurobiol, 2024 Apr. PMID 38367747
    5. Signal-peptide-peptidase-like 2a (SPPL2a) is targeted to lysosomes/late endosomes by a tyrosine motif in its C-terminal tail. Behnke J, et al. FEBS Lett, 2011 Oct 3. PMID 21896273

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Signal peptide peptidase-like 2b modulates the amyloidogenic pathway and exhibits an Abeta-dependent expression in Alzheimer's disease.
      Title: Signal peptide peptidase-like 2b modulates the amyloidogenic pathway and exhibits an Aβ-dependent expression in Alzheimer's disease.
    2. The intramembrane proteases SPPL2a and SPPL2b regulate the homeostasis of selected SNARE proteins.
      Title: The intramembrane proteases SPPL2a and SPPL2b regulate the homeostasis of selected SNARE proteins.
    3. SPPL2a/b negatively regulates LOX-1 signaling and atherosclerosis.
      Title: Atherogenic LOX-1 signaling is controlled by SPPL2-mediated intramembrane proteolysis.
    4. in vivo SPPL2a, but not SPPL2b, exhibit a physiologically relevant contribution to CD74 proteolysis in B and dendritic cells
      Title: The intramembrane proteases signal Peptide peptidase-like 2a and 2b have distinct functions in vivo.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Gene trapped (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables aspartic endopeptidase activity, intramembrane cleaving IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables aspartic endopeptidase activity, intramembrane cleaving ISO
    Inferred from Sequence Orthology
    more info
    		  
    NOT enables aspartic endopeptidase activity, intramembrane cleaving ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein homodimerization activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in membrane protein ectodomain proteolysis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in membrane protein ectodomain proteolysis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in membrane protein intracellular domain proteolysis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in membrane protein intracellular domain proteolysis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in membrane protein proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in membrane protein proteolysis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in membrane protein proteolysis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of immune response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of immune response ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in Golgi-associated vesicle membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi-associated vesicle membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in Golgi-associated vesicle membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in actin cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in actin cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in centrosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasmic side of endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasmic side of endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasmic side of endoplasmic reticulum membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in endosome membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endosome membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in lumenal side of endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in lumenal side of endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in lumenal side of endoplasmic reticulum membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in lysosomal membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in lysosomal membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in lysosomal membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    signal peptide peptidase-like 2B
    Names
    protein SPP-like 2B
    protein SPPL2b
    NP_001345732.1
    NP_001345733.1
    NP_780404.2
    XP_006514272.1
    XP_006514273.1
    XP_006514274.1
    XP_006514275.1
    XP_006514276.1
    XP_011241887.1
    XP_017169608.1
    XP_030101169.1
    XP_030101170.1
    XP_030101171.1
    XP_030101172.1
    XP_030101173.1
    XP_030101174.1
    XP_036011937.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001358803.1 → NP_001345732.1  signal peptide peptidase-like 2B isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      AC166937, AK148109, BB848740, BC052094, CK389382
      Conserved Domains (2) summary
      cd02129
      Location:38 → 157
      PA_hSPPL_like; Protease-associated domain containing human signal peptide peptidase-like (hSPPL)-like. This group contains various PA domain-containing proteins similar to hSPPL2a and 2b. These SPPLs are GxGD aspartic proteases. SPPL2a is sorted to the late endosomes, ...
      pfam04258
      Location:207 → 499
      Peptidase_A22B; Signal peptide peptidase

    2. NM_001358804.1 → NP_001345733.1  signal peptide peptidase-like 2B isoform 3

      Status: VALIDATED

      Source sequence(s)
      AK148109, BC052094
      Conserved Domains (1) summary
      cl01342
      Location:1 → 209
      Peptidase_A22B; Signal peptide peptidase

    3. NM_175195.3 → NP_780404.2  signal peptide peptidase-like 2B isoform 1 precursor

      See identical proteins and their annotated locations for NP_780404.2

      Status: VALIDATED

      Source sequence(s)
      AK148109, BB848740, BC052094
      Consensus CDS
      CCDS35988.1
      UniProtKB/Swiss-Prot
      Q3TD49, Q3TLQ8, Q3UG60, Q80VZ6
      Related
      ENSMUSP00000036289.9, ENSMUST00000035597.10
      Conserved Domains (2) summary
      cd02129
      Location:38 → 157
      PA_hSPPL_like; PA_hSPPL_like: Protease-associated domain containing human signal peptide peptidase-like (hSPPL)-like. This group contains various PA domain-containing proteins similar to hSPPL2a and 2b. These SPPLs are GxGD aspartic proteases. SPPL2a is sorted to the ...
      pfam04258
      Location:206 → 498
      Peptidase_A22B; Signal peptide peptidase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      80691067..80704542
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030245311.2 → XP_030101171.1  signal peptide peptidase-like 2B isoform X10

      Conserved Domains (2) summary
      cd02129
      Location:38 → 157
      PA_hSPPL_like; Protease-associated domain containing human signal peptide peptidase-like (hSPPL)-like. This group contains various PA domain-containing proteins similar to hSPPL2a and 2b. These SPPLs are GxGD aspartic proteases. SPPL2a is sorted to the late endosomes, ...
      pfam04258
      Location:206 → 498
      Peptidase_A22B; Signal peptide peptidase

    2. XM_030245312.2 → XP_030101172.1  signal peptide peptidase-like 2B isoform X10

      Conserved Domains (2) summary
      cd02129
      Location:38 → 157
      PA_hSPPL_like; Protease-associated domain containing human signal peptide peptidase-like (hSPPL)-like. This group contains various PA domain-containing proteins similar to hSPPL2a and 2b. These SPPLs are GxGD aspartic proteases. SPPL2a is sorted to the late endosomes, ...
      pfam04258
      Location:206 → 498
      Peptidase_A22B; Signal peptide peptidase

    3. XM_006514210.4 → XP_006514273.1  signal peptide peptidase-like 2B isoform X3

      Conserved Domains (3) summary
      PRK14666
      Location:491 → 573
      uvrC; excinuclease ABC subunit C; Provisional
      cd02129
      Location:38 → 157
      PA_hSPPL_like; Protease-associated domain containing human signal peptide peptidase-like (hSPPL)-like. This group contains various PA domain-containing proteins similar to hSPPL2a and 2b. These SPPLs are GxGD aspartic proteases. SPPL2a is sorted to the late endosomes, ...
      pfam04258
      Location:206 → 498
      Peptidase_A22B; Signal peptide peptidase

    4. XM_030245310.2 → XP_030101170.1  signal peptide peptidase-like 2B isoform X9

      Conserved Domains (2) summary
      cd02129
      Location:38 → 157
      PA_hSPPL_like; Protease-associated domain containing human signal peptide peptidase-like (hSPPL)-like. This group contains various PA domain-containing proteins similar to hSPPL2a and 2b. These SPPLs are GxGD aspartic proteases. SPPL2a is sorted to the late endosomes, ...
      pfam04258
      Location:207 → 499
      Peptidase_A22B; Signal peptide peptidase

    5. XM_006514212.4 → XP_006514275.1  signal peptide peptidase-like 2B isoform X6

      See identical proteins and their annotated locations for XP_006514275.1

      Conserved Domains (2) summary
      cd02129
      Location:38 → 157
      PA_hSPPL_like; Protease-associated domain containing human signal peptide peptidase-like (hSPPL)-like. This group contains various PA domain-containing proteins similar to hSPPL2a and 2b. These SPPLs are GxGD aspartic proteases. SPPL2a is sorted to the late endosomes, ...
      pfam04258
      Location:207 → 499
      Peptidase_A22B; Signal peptide peptidase

    6. XM_006514209.4 → XP_006514272.1  signal peptide peptidase-like 2B isoform X1

      See identical proteins and their annotated locations for XP_006514272.1

      Conserved Domains (2) summary
      cd02129
      Location:38 → 157
      PA_hSPPL_like; Protease-associated domain containing human signal peptide peptidase-like (hSPPL)-like. This group contains various PA domain-containing proteins similar to hSPPL2a and 2b. These SPPLs are GxGD aspartic proteases. SPPL2a is sorted to the late endosomes, ...
      pfam04258
      Location:207 → 499
      Peptidase_A22B; Signal peptide peptidase

    7. XM_017314119.3 → XP_017169608.1  signal peptide peptidase-like 2B isoform X2

      Conserved Domains (3) summary
      PRK14666
      Location:492 → 574
      uvrC; excinuclease ABC subunit C; Provisional
      cd02129
      Location:38 → 157
      PA_hSPPL_like; Protease-associated domain containing human signal peptide peptidase-like (hSPPL)-like. This group contains various PA domain-containing proteins similar to hSPPL2a and 2b. These SPPLs are GxGD aspartic proteases. SPPL2a is sorted to the late endosomes, ...
      pfam04258
      Location:207 → 499
      Peptidase_A22B; Signal peptide peptidase

    8. XM_006514211.5 → XP_006514274.1  signal peptide peptidase-like 2B isoform X4

      Conserved Domains (2) summary
      cd02129
      Location:38 → 157
      PA_hSPPL_like; Protease-associated domain containing human signal peptide peptidase-like (hSPPL)-like. This group contains various PA domain-containing proteins similar to hSPPL2a and 2b. These SPPLs are GxGD aspartic proteases. SPPL2a is sorted to the late endosomes, ...
      pfam04258
      Location:207 → 460
      Peptidase_A22B; Signal peptide peptidase

    9. XM_011243585.4 → XP_011241887.1  signal peptide peptidase-like 2B isoform X5

      Conserved Domains (2) summary
      cd02129
      Location:38 → 157
      PA_hSPPL_like; Protease-associated domain containing human signal peptide peptidase-like (hSPPL)-like. This group contains various PA domain-containing proteins similar to hSPPL2a and 2b. These SPPLs are GxGD aspartic proteases. SPPL2a is sorted to the late endosomes, ...
      pfam04258
      Location:206 → 459
      Peptidase_A22B; Signal peptide peptidase

    10. XM_006514213.5 → XP_006514276.1  signal peptide peptidase-like 2B isoform X7

      Conserved Domains (2) summary
      pfam04258
      Location:146 → 438
      Peptidase_A22B; Signal peptide peptidase
      cl28883
      Location:38 → 96
      PA; Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain. At ...

    11. XM_030245309.2 → XP_030101169.1  signal peptide peptidase-like 2B isoform X8

      Conserved Domains (2) summary
      pfam04258
      Location:145 → 437
      Peptidase_A22B; Signal peptide peptidase
      cl28883
      Location:38 → 96
      PA; Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain. At ...

    12. XM_030245314.2 → XP_030101174.1  signal peptide peptidase-like 2B isoform X12

      Conserved Domains (1) summary
      cl01342
      Location:1 → 209
      Peptidase_A22B; Signal peptide peptidase

    13. XM_036156044.1 → XP_036011937.1  signal peptide peptidase-like 2B isoform X11

      UniProtKB/TrEMBL
      Q8BXJ5
      Conserved Domains (1) summary
      pfam04258
      Location:54 → 346
      Peptidase_A22B; Signal peptide peptidase

    14. XM_030245313.1 → XP_030101173.1  signal peptide peptidase-like 2B isoform X11

      UniProtKB/TrEMBL
      Q8BXJ5
      Conserved Domains (1) summary
      pfam04258
      Location:54 → 346
      Peptidase_A22B; Signal peptide peptidase

    RNA

    1. XR_004936292.1 RNA Sequence

    2. XR_004936291.1 RNA Sequence

    3. XR_003948809.2 RNA Sequence

    4. XR_004936293.1 RNA Sequence

    5. XR_003948810.2 RNA Sequence

    6. XR_004936290.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3TD49.2 GenPept UniProtKB/Swiss-Prot:Q3TD49

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