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    Cdkl1 cyclin dependent kinase like 1 [ Mus musculus (house mouse) ]

    Gene ID: 71091, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Cdkl1provided by MGI
    Official Full Name
    cyclin dependent kinase like 1provided by MGI
    Primary source
    MGI:MGI:1918341
    See related
    Ensembl:ENSMUSG00000020990 AllianceGenome:MGI:1918341
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    4933411O17Rik
    Summary
    Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in regulation of cilium assembly. Predicted to be located in ciliary transition zone and nucleoplasm. Predicted to be active in nucleus. Is expressed in renal calyx and rest of cerebellum mantle layer. Orthologous to human CDKL1 (cyclin dependent kinase like 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in kidney adult (RPKM 23.9), ovary adult (RPKM 3.4) and 7 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Cdkl1 in Genome Data Viewer
    Location:
    12 C2; 12 28.94 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (69791944..69838057, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (69745167..69791196, complement)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene L-2-hydroxyglutarate dehydrogenase Neighboring gene STARR-seq mESC enhancer starr_32374 Neighboring gene STARR-positive B cell enhancer ABC_E2387 Neighboring gene STARR-positive B cell enhancer mm9_chr12:70834549-70834850 Neighboring gene distal membrane arm assembly component 2 like Neighboring gene VISTA enhancer mm122 Neighboring gene microRNA 681 Neighboring gene RIKEN cDNA 4930512B01 gene Neighboring gene mitogen-activated protein kinase kinase kinase kinase 5 Neighboring gene STARR-seq mESC enhancer starr_32378 Neighboring gene ribosomal protein S2 pseudogene Neighboring gene RIKEN cDNA 4931403G20 gene Neighboring gene STARR-positive B cell enhancer ABC_E8487

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. High-throughput mapping of a dynamic signaling network in mammalian cells. Barrios-Rodiles M, et al. Science, 2005 Mar 11. PMID 15761153
    2. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
    3. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
    4. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
    5. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Gene trapped (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC144706, MGC144707

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cyclin-dependent protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of cilium assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in ciliary transition zone ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    cyclin-dependent kinase-like 1
    Names
    cyclin dependent kinase like 1 (CDC2 related kinase)
    NP_899117.1
    XP_011242478.1
    XP_011242479.1
    XP_017170692.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_183294.2 → NP_899117.1  cyclin-dependent kinase-like 1

      See identical proteins and their annotated locations for NP_899117.1

      Status: PROVISIONAL

      Source sequence(s)
      AK016781
      Consensus CDS
      CCDS25955.1
      UniProtKB/Swiss-Prot
      Q8CEQ0
      UniProtKB/TrEMBL
      Q14BG3
      Related
      ENSMUSP00000021377.5, ENSMUST00000021377.5
      Conserved Domains (1) summary
      cd07847
      Location:2 → 287
      STKc_CDKL1_4; Catalytic domain of the Serine/Threonine Kinases, Cyclin-Dependent protein Kinase Like 1 and 4

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      69791944..69838057 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011244176.4 → XP_011242478.1  cyclin-dependent kinase-like 1 isoform X2

      See identical proteins and their annotated locations for XP_011242478.1

      Conserved Domains (1) summary
      cl21453
      Location:44 → 212
      PKc_like; Protein Kinases, catalytic domain

    2. XM_017315203.3 → XP_017170692.1  cyclin-dependent kinase-like 1 isoform X1

      UniProtKB/Swiss-Prot
      Q8CEQ0
      UniProtKB/TrEMBL
      Q14BG3
      Conserved Domains (1) summary
      cd07847
      Location:2 → 287
      STKc_CDKL1_4; Catalytic domain of the Serine/Threonine Kinases, Cyclin-Dependent protein Kinase Like 1 and 4

    3. XM_011244177.4 → XP_011242479.1  cyclin-dependent kinase-like 1 isoform X2

      See identical proteins and their annotated locations for XP_011242479.1

      Conserved Domains (1) summary
      cl21453
      Location:44 → 212
      PKc_like; Protein Kinases, catalytic domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8CEQ0.1 GenPept UniProtKB/Swiss-Prot:Q8CEQ0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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