Arhgap12 Rho GTPase activating protein 12 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Arhgap12provided by MGI
Official Full Name: Rho GTPase activating protein 12provided by MGI
Primary source: MGI:MGI:1922665
See related: Ensembl:ENSMUSG00000041225 AllianceGenome:MGI:1922665
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 2810011M08Rik
Summary: Predicted to enable GTPase activator activity. Predicted to be involved in several processes, including negative regulation of small GTPase mediated signal transduction; phagocytosis, engulfment; and small GTPase-mediated signal transduction. Predicted to be located in phagocytic cup. Predicted to be active in cytoplasm and plasma membrane. Is expressed in bladder; gut; nervous system; sensory organ; and skeleton. Orthologous to human ARHGAP12 (Rho GTPase activating protein 12). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in bladder adult (RPKM 10.7), CNS E14 (RPKM 8.1) and 25 other tissues See more
Orthologs: human all
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Genomic context

Location:: 18 A1; 18 4.46 cM

Exon count:: 20

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	18	NC_000084.7 (6024448..6136102, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	18	NC_000084.6 (6024448..6136098, complement)

Chromosome 18 - NC_000084.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Circular RNA Arhgap12 modulates doxorubicin-induced cardiotoxicity by sponging miR-135a-5p.
Title: Circular RNA Arhgap12 modulates doxorubicin-induced cardiotoxicity by sponging miR-135a-5p.
ARHGAP12 inactivates RAC1, thereby impairing cell motility, invasion and adhesion to the extracellular matrix. The gene is transcriptionally suppressed by Hepatocyte Growth Factor in human and murine cell lines.
Title: Met-driven invasive growth involves transcriptional regulation of Arhgap12.
Immunofluorescence staining and confocal laser-scanning microscopy demonstrated that Arhgap12 localizes at epithelial cell-cell adherent junctions in various mouse tissues.
Title: Identification of adherens junction-associated GTPase activating proteins by the fluorescence localization-based expression cloning.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Gene trapped (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D18Mit64 (e-PCR), detects polymorphism
- UniSTS:116790

C87835 (e-PCR)
- UniSTS:209354

RH135886 (e-PCR)
- UniSTS:209884

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables GTPase activator activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activator activity	IEA Inferred from Electronic Annotation more info
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in actin filament organization	ISO Inferred from Sequence Orthology more info
involved_in actin filament organization	ISS Inferred from Sequence or Structural Similarity more info
involved_in morphogenesis of an epithelial sheet	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of small GTPase mediated signal transduction	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of small GTPase mediated signal transduction	ISS Inferred from Sequence or Structural Similarity more info
involved_in phagocytosis, engulfment	ISO Inferred from Sequence Orthology more info
involved_in phagocytosis, engulfment	ISS Inferred from Sequence or Structural Similarity more info
involved_in signal transduction	IEA Inferred from Electronic Annotation more info
involved_in small GTPase-mediated signal transduction	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in phagocytic cup	ISO Inferred from Sequence Orthology more info
located_in phagocytic cup	ISS Inferred from Sequence or Structural Similarity more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: rho GTPase-activating protein 12

Names: rho-type GTPase-activating protein 12

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001039692.1 → NP_001034781.1 rho GTPase-activating protein 12 isoform 1

See identical proteins and their annotated locations for NP_001034781.1

Status: VALIDATED

Source sequence(s)

AC168050, AK031648, AK077063, BC037608

Consensus CDS

CCDS37723.1

UniProtKB/Swiss-Prot

Q8BVP8, Q8C0D4

Related

ENSMUSP00000138585.2, ENSMUST00000182559.8

Conserved Domains (6) summary

cd12070
Location:13 → 72

SH3_ARHGAP12; Src Homology 3 domain of Rho GTPase-activating protein 12

cd00201
Location:266 → 296

WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...

cd04403
Location:646 → 831

RhoGAP_ARHGAP27_15_12_9; RhoGAP_ARHGAP27_15_12_9: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. ...

cd13233
Location:457 → 568

PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain

pfam00169
Location:467 → 566

PH; PH domain

pfam16618
Location:69 → 264

SH3-WW_linker; Linker region between SH3 and WW domains on ARHGAP12
NM_029277.2 → NP_083553.2 rho GTPase-activating protein 12 isoform 2

See identical proteins and their annotated locations for NP_083553.2

Status: VALIDATED

Source sequence(s)

AC168050, AK077063, BC037608

Consensus CDS

CCDS37722.1

UniProtKB/TrEMBL

B2RUJ8

Related

ENSMUSP00000076376.6, ENSMUST00000077128.13

Conserved Domains (6) summary

cd12070
Location:13 → 72

SH3_ARHGAP12; Src Homology 3 domain of Rho GTPase-activating protein 12

cd00201
Location:266 → 296

WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...

cd04403
Location:621 → 806

RhoGAP_ARHGAP27_15_12_9; RhoGAP_ARHGAP27_15_12_9: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. ...

cd13233
Location:432 → 543

PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain

pfam00169
Location:442 → 541

PH; PH domain

pfam16618
Location:69 → 264

SH3-WW_linker; Linker region between SH3 and WW domains on ARHGAP12

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000084.7 Reference GRCm39 C57BL/6J

Range

6024448..6136102 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030250623.2 → XP_030106483.1 rho GTPase-activating protein 12 isoform X8

Conserved Domains (4) summary

cd12070
Location:13 → 72

SH3_ARHGAP12; Src Homology 3 domain of Rho GTPase-activating protein 12

cd04403
Location:487 → 672

RhoGAP_ARHGAP27_15_12_9; GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. Most members that are ...

cd13233
Location:298 → 409

PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain

pfam16618
Location:69 → 226

SH3-WW_linker; Linker region between SH3 and WW domains on ARHGAP12
XM_036161302.1 → XP_036017195.1 rho GTPase-activating protein 12 isoform X7

Conserved Domains (4) summary

cd12070
Location:13 → 72

SH3_ARHGAP12; Src Homology 3 domain of Rho GTPase-activating protein 12

cd04403
Location:512 → 697

RhoGAP_ARHGAP27_15_12_9; GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. Most members that are ...

cd13233
Location:323 → 434

PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain

pfam16618
Location:69 → 226

SH3-WW_linker; Linker region between SH3 and WW domains on ARHGAP12
XM_017318001.2 → XP_017173490.1 rho GTPase-activating protein 12 isoform X6

Conserved Domains (4) summary

cd12070
Location:13 → 72

SH3_ARHGAP12; Src Homology 3 domain of Rho GTPase-activating protein 12

cd04403
Location:517 → 702

RhoGAP_ARHGAP27_15_12_9; GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. Most members that are ...

cd13233
Location:328 → 439

PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain

pfam16618
Location:69 → 226

SH3-WW_linker; Linker region between SH3 and WW domains on ARHGAP12
XM_006526316.2 → XP_006526379.1 rho GTPase-activating protein 12 isoform X5

UniProtKB/TrEMBL

S4R203

Related

ENSMUSP00000138444.2, ENSMUST00000182383.8

Conserved Domains (6) summary

cd12070
Location:13 → 72

SH3_ARHGAP12; Src Homology 3 domain of Rho GTPase-activating protein 12

COG5104
Location:257 → 362

PRP40; Splicing factor [RNA processing and modification]

cd00201
Location:266 → 296

WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...

cd04403
Location:574 → 759

RhoGAP_ARHGAP27_15_12_9; GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. Most members that are ...

cd13233
Location:385 → 496

PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain

pfam16618
Location:69 → 264

SH3-WW_linker; Linker region between SH3 and WW domains on ARHGAP12
XM_036161301.1 → XP_036017194.1 rho GTPase-activating protein 12 isoform X4

UniProtKB/TrEMBL

S4R248

Related

ENSMUSP00000138496.2, ENSMUST00000182066.8

Conserved Domains (6) summary

cd12070
Location:13 → 72

SH3_ARHGAP12; Src Homology 3 domain of Rho GTPase-activating protein 12

COG5104
Location:257 → 362

PRP40; Splicing factor [RNA processing and modification]

cd00201
Location:266 → 296

WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...

cd04403
Location:599 → 784

RhoGAP_ARHGAP27_15_12_9; GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. Most members that are ...

cd13233
Location:410 → 521

PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain

pfam16618
Location:69 → 264

SH3-WW_linker; Linker region between SH3 and WW domains on ARHGAP12
XM_006526315.2 → XP_006526378.1 rho GTPase-activating protein 12 isoform X3

UniProtKB/TrEMBL

A0A0A0MQ95

Related

ENSMUSP00000054209.8, ENSMUST00000062584.14

Conserved Domains (6) summary

cd12070
Location:13 → 72

SH3_ARHGAP12; Src Homology 3 domain of Rho GTPase-activating protein 12

COG5104
Location:257 → 362

PRP40; Splicing factor [RNA processing and modification]

cd00201
Location:266 → 296

WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...

cd04403
Location:604 → 789

RhoGAP_ARHGAP27_15_12_9; GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. Most members that are ...

cd13233
Location:415 → 526

PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain

pfam16618
Location:69 → 264

SH3-WW_linker; Linker region between SH3 and WW domains on ARHGAP12
XM_011247018.2 → XP_011245320.1 rho GTPase-activating protein 12 isoform X2

Conserved Domains (6) summary

cd12070
Location:13 → 72

SH3_ARHGAP12; Src Homology 3 domain of Rho GTPase-activating protein 12

COG5104
Location:257 → 409

PRP40; Splicing factor [RNA processing and modification]

cd00201
Location:266 → 296

WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...

cd04403
Location:626 → 811

RhoGAP_ARHGAP27_15_12_9; GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. Most members that are ...

cd13233
Location:437 → 548

PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain

pfam16618
Location:69 → 264

SH3-WW_linker; Linker region between SH3 and WW domains on ARHGAP12
XM_006526314.2 → XP_006526377.1 rho GTPase-activating protein 12 isoform X1

UniProtKB/TrEMBL

S4R221

Related

ENSMUSP00000138464.2, ENSMUST00000182213.8

Conserved Domains (6) summary

cd12070
Location:13 → 72

SH3_ARHGAP12; Src Homology 3 domain of Rho GTPase-activating protein 12

COG5104
Location:257 → 409

PRP40; Splicing factor [RNA processing and modification]

cd00201
Location:266 → 296

WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...

cd04403
Location:651 → 836

RhoGAP_ARHGAP27_15_12_9; GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. Most members that are ...

cd13233
Location:462 → 573

PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain

pfam16618
Location:69 → 264

SH3-WW_linker; Linker region between SH3 and WW domains on ARHGAP12