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    Anks3 ankyrin repeat and sterile alpha motif domain containing 3 [ Mus musculus (house mouse) ]

    Gene ID: 72615, updated on 4-Jan-2025

    Summary

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    Official Symbol
    Anks3provided by MGI
    Official Full Name
    ankyrin repeat and sterile alpha motif domain containing 3provided by MGI
    Primary source
    MGI:MGI:1919865
    See related
    Ensembl:ENSMUSG00000022515 AllianceGenome:MGI:1919865
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mKIAA1977; 2700067D09Rik
    Summary
    Located in cilium and cytoplasm. Is expressed in several structures, including brain and retina nuclear layer. Orthologous to human ANKS3 (ankyrin repeat and sterile alpha motif domain containing 3). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Ubiquitous expression in CNS E14 (RPKM 12.6), CNS E18 (RPKM 12.3) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Anks3 in Genome Data Viewer
    Location:
    16 A1; 16 2.48 cM
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (4759290..4783362, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (4941415..4965537, complement)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene mahogunin, ring finger 1 Neighboring gene STARR-positive B cell enhancer mm9_chr16:4938936-4939237 Neighboring gene predicted gene, 16861 Neighboring gene nudix hydrolase 16 like 1 Neighboring gene predicted gene, 36681 Neighboring gene dynein axonemal assembly factor 8 Neighboring gene septin 12 Neighboring gene small integral membrane protein 22

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Metabolic Phenotyping of Anks3 Depletion in mIMCD-3 cells - a Putative Nephronophthisis Candidate. Schlimpert M, et al. Sci Rep, 2018 Jun 13. PMID 29899363, Free PMC Article
    2. Bicc1 ribonucleoprotein complexes specifying organ laterality are licensed by ANKS6-induced structural remodeling of associated ANKS3. Rothé B, et al. PLoS Biol, 2023 Sep. PMID 37733651, Free PMC Article
    3. ANKS3 Co-Localises with ANKS6 in Mouse Renal Cilia and Is Associated with Vasopressin Signaling and Apoptosis In Vivo in Mice. Delestré L, et al. PLoS One, 2015. PMID 26327442, Free PMC Article
    4. Anks3 alters the sub-cellular localization of the Nek7 kinase. Ramachandran H, et al. Biochem Biophys Res Commun, 2015 Aug 28. PMID 26188091
    5. Anks3 interacts with nephronophthisis proteins and is required for normal renal development. Yakulov TA, et al. Kidney Int, 2015 Jun. PMID 25671767

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Combined metabolomics successfully identified 155 metabolites; 48 metabolites were identified to be significantly altered by decreasing Ankyrin repeat and sterile alpha motif domain containing 3 protein (Anks3) levels.
      Title: Metabolic Phenotyping of Anks3 Depletion in mIMCD-3 cells - a Putative Nephronophthisis Candidate.
    2. ANKS3-ANKS6 direct interaction through their SAM domain.
      Title: ANKS3 Co-Localises with ANKS6 in Mouse Renal Cilia and Is Associated with Vasopressin Signaling and Apoptosis In Vivo in Mice.
    3. Anks3 N-terminal ankyrin repeats, but not SAM domain required for Nek7 interaction.Nek7 increased Ser/Thr phosphorylation of Anks3 primarily within ankyrin domain.
      Title: Anks3 alters the sub-cellular localization of the Nek7 kinase.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cilium IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cilium IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    ankyrin repeat and SAM domain-containing protein 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_028301.5 → NP_082577.2  ankyrin repeat and SAM domain-containing protein 3

      Status: VALIDATED

      Source sequence(s)
      AC163723, AC240849
      Consensus CDS
      CCDS27928.1
      UniProtKB/Swiss-Prot
      Q6ZPF6, Q80X46, Q9CZK6
      Related
      ENSMUSP00000023157.5, ENSMUST00000023157.6
      Conserved Domains (6) summary
      cd09519
      Location:423 → 486
      SAM_ANKS3; SAM domain of ANKS3 subfamily
      smart00454
      Location:422 → 481
      SAM; Sterile alpha motif
      cd00204
      Location:63 → 189
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:106 → 199
      Ank_2; Ankyrin repeats (3 copies)
      pfam15134
      Location:512 → 608
      DUF4570; Domain of unknown function (DUF4570)
      sd00045
      Location:69 → 99
      ANK; ANK repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      4759290..4783362 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006522608.2 → XP_006522671.1  ankyrin repeat and SAM domain-containing protein 3 isoform X1

      Conserved Domains (5) summary
      cd09519
      Location:423 → 486
      SAM_ANKS3; SAM domain of ANKS3 subfamily
      COG0666
      Location:29 → 192
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      sd00045
      Location:69 → 99
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:169 → 221
      Ank_4; Ankyrin repeats (many copies)
      pfam15134
      Location:512 → 608
      DUF4570; Domain of unknown function (DUF4570)

    2. XM_006522610.3 → XP_006522673.1  ankyrin repeat and SAM domain-containing protein 3 isoform X3

      Conserved Domains (5) summary
      cd09519
      Location:423 → 486
      SAM_ANKS3; SAM domain of ANKS3 subfamily
      COG0666
      Location:29 → 192
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      sd00045
      Location:69 → 99
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:169 → 221
      Ank_4; Ankyrin repeats (many copies)
      pfam15134
      Location:512 → 608
      DUF4570; Domain of unknown function (DUF4570)

    3. XM_036160143.1 → XP_036016036.1  ankyrin repeat and SAM domain-containing protein 3 isoform X8

      Conserved Domains (3) summary
      cd09519
      Location:350 → 413
      SAM_ANKS3; SAM domain of ANKS3 subfamily
      sd00045
      Location:28 → 59
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:33 → 126
      Ank_2; Ankyrin repeats (3 copies)

    4. XM_030249288.2 → XP_030105148.1  ankyrin repeat and SAM domain-containing protein 3 isoform X7

      Conserved Domains (5) summary
      cd09519
      Location:362 → 425
      SAM_ANKS3; SAM domain of ANKS3 subfamily
      PLN03192
      Location:16 → 185
      PLN03192; Voltage-dependent potassium channel; Provisional
      sd00045
      Location:73 → 104
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:62 → 138
      Ank_2; Ankyrin repeats (3 copies)
      pfam15134
      Location:451 → 547
      DUF4570; Domain of unknown function (DUF4570)

    5. XM_036160146.1 → XP_036016039.1  ankyrin repeat and SAM domain-containing protein 3 isoform X14

      Conserved Domains (2) summary
      cd09519
      Location:250 → 313
      SAM_ANKS3; SAM domain of ANKS3 subfamily
      cl39094
      Location:1 → 48
      Ank_2; Ankyrin repeats (3 copies)

    6. XM_006522609.4 → XP_006522672.1  ankyrin repeat and SAM domain-containing protein 3 isoform X2

      Conserved Domains (5) summary
      cd09519
      Location:423 → 486
      SAM_ANKS3; SAM domain of ANKS3 subfamily
      COG0666
      Location:29 → 192
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      sd00045
      Location:69 → 99
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:169 → 221
      Ank_4; Ankyrin repeats (many copies)
      pfam15134
      Location:512 → 608
      DUF4570; Domain of unknown function (DUF4570)

    7. XM_030249290.2 → XP_030105150.1  ankyrin repeat and SAM domain-containing protein 3 isoform X9

      Conserved Domains (5) summary
      cd09519
      Location:362 → 425
      SAM_ANKS3; SAM domain of ANKS3 subfamily
      PLN03192
      Location:16 → 185
      PLN03192; Voltage-dependent potassium channel; Provisional
      sd00045
      Location:73 → 104
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:62 → 138
      Ank_2; Ankyrin repeats (3 copies)
      pfam15134
      Location:451 → 547
      DUF4570; Domain of unknown function (DUF4570)

    8. XM_030249287.1 → XP_030105147.1  ankyrin repeat and SAM domain-containing protein 3 isoform X6

      Conserved Domains (5) summary
      cd09519
      Location:362 → 425
      SAM_ANKS3; SAM domain of ANKS3 subfamily
      PLN03192
      Location:16 → 185
      PLN03192; Voltage-dependent potassium channel; Provisional
      sd00045
      Location:73 → 104
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:62 → 138
      Ank_2; Ankyrin repeats (3 copies)
      pfam15134
      Location:451 → 547
      DUF4570; Domain of unknown function (DUF4570)

    9. XM_006522611.5 → XP_006522674.1  ankyrin repeat and SAM domain-containing protein 3 isoform X4

      Conserved Domains (5) summary
      cd09519
      Location:362 → 425
      SAM_ANKS3; SAM domain of ANKS3 subfamily
      PLN03192
      Location:16 → 185
      PLN03192; Voltage-dependent potassium channel; Provisional
      sd00045
      Location:73 → 104
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:62 → 138
      Ank_2; Ankyrin repeats (3 copies)
      pfam15134
      Location:451 → 547
      DUF4570; Domain of unknown function (DUF4570)

    10. XM_030249289.2 → XP_030105149.1  ankyrin repeat and SAM domain-containing protein 3 isoform X8

      Conserved Domains (3) summary
      cd09519
      Location:350 → 413
      SAM_ANKS3; SAM domain of ANKS3 subfamily
      sd00045
      Location:28 → 59
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:33 → 126
      Ank_2; Ankyrin repeats (3 copies)

    11. XM_006522612.3 → XP_006522675.1  ankyrin repeat and SAM domain-containing protein 3 isoform X5

      Conserved Domains (4) summary
      cd09519
      Location:350 → 413
      SAM_ANKS3; SAM domain of ANKS3 subfamily
      sd00045
      Location:28 → 59
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:33 → 126
      Ank_2; Ankyrin repeats (3 copies)
      pfam15134
      Location:439 → 535
      DUF4570; Domain of unknown function (DUF4570)

    12. XM_036160145.1 → XP_036016038.1  ankyrin repeat and SAM domain-containing protein 3 isoform X12

      Conserved Domains (3) summary
      cd09519
      Location:294 → 357
      SAM_ANKS3; SAM domain of ANKS3 subfamily
      sd00045
      Location:5 → 36
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:1 → 70
      Ank_2; Ankyrin repeats (3 copies)

    13. XM_006522613.4 → XP_006522676.1  ankyrin repeat and SAM domain-containing protein 3 isoform X10

      Conserved Domains (4) summary
      cd09519
      Location:294 → 357
      SAM_ANKS3; SAM domain of ANKS3 subfamily
      sd00045
      Location:5 → 36
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:1 → 70
      Ank_2; Ankyrin repeats (3 copies)
      pfam15134
      Location:383 → 479
      DUF4570; Domain of unknown function (DUF4570)

    14. XM_030249291.2 → XP_030105151.1  ankyrin repeat and SAM domain-containing protein 3 isoform X11

      Conserved Domains (3) summary
      cd09519
      Location:250 → 313
      SAM_ANKS3; SAM domain of ANKS3 subfamily
      pfam12796
      Location:1 → 48
      Ank_2; Ankyrin repeats (3 copies)
      pfam15134
      Location:339 → 435
      DUF4570; Domain of unknown function (DUF4570)

    15. XM_030249294.2 → XP_030105154.1  ankyrin repeat and SAM domain-containing protein 3 isoform X13

      Conserved Domains (3) summary
      cd09519
      Location:250 → 313
      SAM_ANKS3; SAM domain of ANKS3 subfamily
      pfam12796
      Location:1 → 48
      Ank_2; Ankyrin repeats (3 copies)
      pfam15134
      Location:339 → 435
      DUF4570; Domain of unknown function (DUF4570)

    16. XM_030249292.2 → XP_030105152.1  ankyrin repeat and SAM domain-containing protein 3 isoform X11

      Conserved Domains (3) summary
      cd09519
      Location:250 → 313
      SAM_ANKS3; SAM domain of ANKS3 subfamily
      pfam12796
      Location:1 → 48
      Ank_2; Ankyrin repeats (3 copies)
      pfam15134
      Location:339 → 435
      DUF4570; Domain of unknown function (DUF4570)

    RNA

    1. XR_004939242.1 RNA Sequence

    2. XR_004939236.1 RNA Sequence

    3. XR_004939235.1 RNA Sequence

    4. XR_004939234.1 RNA Sequence

    5. XR_004939239.1 RNA Sequence

    6. XR_004939238.1 RNA Sequence

    7. XR_003951838.1 RNA Sequence

    8. XR_004939237.1 RNA Sequence

    9. XR_004939241.1 RNA Sequence

    10. XR_004939240.1 RNA Sequence

    11. XR_003951841.1 RNA Sequence

    12. XR_003951840.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9CZK6.2 GenPept UniProtKB/Swiss-Prot:Q9CZK6

    Gene LinkOut

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