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    Lmf2 lipase maturation factor 2 [ Mus musculus (house mouse) ]

    Gene ID: 105847, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Lmf2provided by MGI
    Official Full Name
    lipase maturation factor 2provided by MGI
    Primary source
    MGI:MGI:2146015
    See related
    Ensembl:ENSMUSG00000022614 AllianceGenome:MGI:2146015
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Tmem153; Tmem112b
    Summary
    Predicted to be involved in protein maturation. Predicted to be active in endoplasmic reticulum membrane. Is expressed in cerebral cortex ventricular layer. Orthologous to human LMF2 (lipase maturation factor 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in thymus adult (RPKM 40.6), lung adult (RPKM 35.0) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Lmf2 in Genome Data Viewer
    Location:
    15 E3; 15 44.84 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (89235203..89239860, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (89351004..89355694, complement)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene adrenomedullin 2 Neighboring gene STARR-seq mESC enhancer starr_39462 Neighboring gene myo-inositol oxygenase Neighboring gene STARR-positive B cell enhancer ABC_E7405 Neighboring gene STARR-positive B cell enhancer ABC_E3152 Neighboring gene non-SMC condensin II complex, subunit H2 Neighboring gene STARR-seq mESC enhancer starr_39464 Neighboring gene SCO2 cytochrome c oxidase assembly protein Neighboring gene thymidine phosphorylase Neighboring gene ciliary microtubule associated protein 1B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors. Kim H, et al. Cell, 2018 Dec 13. PMID 30550785, Free PMC Article
    2. ALS-linked loss of Cyclin-F function affects HSP90. Siebert A, et al. Life Sci Alliance, 2022 Sep 16. PMID 36114006, Free PMC Article
    3. Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Bedogni F, et al. Front Mol Neurosci, 2021. PMID 34321999, Free PMC Article
    4. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article
    5. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein maturation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein maturation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    lipase maturation factor 2
    Names
    transmembrane protein 112B
    transmembrane protein 153

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001416186.1 → NP_001403115.1  lipase maturation factor 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC113976

    2. NM_001416187.1 → NP_001403116.1  lipase maturation factor 2 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC113976

    3. NM_001416188.1 → NP_001403117.1  lipase maturation factor 2 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC113976

    4. NM_001416189.1 → NP_001403118.1  lipase maturation factor 2 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC113976
      Related
      ENSMUST00000230112.2

    5. NM_001416190.1 → NP_001403119.1  lipase maturation factor 2 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC113976

    6. NM_001416191.1 → NP_001403120.1  lipase maturation factor 2 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC113976

    7. NM_001416192.1 → NP_001403121.1  lipase maturation factor 2 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC113976

    8. NM_001416193.1 → NP_001403122.1  lipase maturation factor 2 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC113976

    9. NM_001416194.1 → NP_001403123.1  lipase maturation factor 2 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC113976

    10. NM_001416195.1 → NP_001403124.1  lipase maturation factor 2 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC113976

    11. NM_001416196.1 → NP_001403125.1  lipase maturation factor 2 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC113976

    12. NM_001416197.1 → NP_001403126.1  lipase maturation factor 2 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC113976

    13. NM_001416198.1 → NP_001403127.1  lipase maturation factor 2 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC113976

    14. NM_001416199.1 → NP_001403128.1  lipase maturation factor 2 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC113976

    15. NM_178919.5 → NP_849250.1  lipase maturation factor 2 isoform 1

      See identical proteins and their annotated locations for NP_849250.1

      Status: VALIDATED

      Source sequence(s)
      AC113976
      Consensus CDS
      CCDS27746.1
      UniProtKB/Swiss-Prot
      Q8C3X8
      Related
      ENSMUSP00000023283.6, ENSMUST00000023283.6
      Conserved Domains (1) summary
      pfam06762
      Location:127 → 587
      LMF1; Lipase maturation factor

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      89235203..89239860 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036159059.1 → XP_036014952.1  lipase maturation factor 2 isoform X1

      Conserved Domains (1) summary
      pfam06762
      Location:1 → 410
      LMF1; Lipase maturation factor

    2. XM_036159060.1 → XP_036014953.1  lipase maturation factor 2 isoform X1

      Related
      ENSMUST00000231067.2
      Conserved Domains (1) summary
      pfam06762
      Location:1 → 410
      LMF1; Lipase maturation factor
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8C3X8.1 GenPept UniProtKB/Swiss-Prot:Q8C3X8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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