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    Lingo3 leucine rich repeat and Ig domain containing 3 [ Mus musculus (house mouse) ]

    Gene ID: 237403, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Lingo3provided by MGI
    Official Full Name
    leucine rich repeat and Ig domain containing 3provided by MGI
    Primary source
    MGI:MGI:3609246
    See related
    Ensembl:ENSMUSG00000051067 AllianceGenome:MGI:3609246
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    LERN2
    Summary
    Predicted to be located in membrane. Predicted to be active in extracellular matrix and extracellular space. Is expressed in several structures, including branchial arch; embryo mesenchyme; eye; heart; and trigeminal preganglion. Orthologous to human LINGO3 (leucine rich repeat and Ig domain containing 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in cerebellum adult (RPKM 10.8), adrenal adult (RPKM 5.6) and 6 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Lingo3 in Genome Data Viewer
    Location:
    10 C1; 10 39.72 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (80668635..80679873, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (80832801..80844039, complement)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene junctional sarcoplasmic reticulum protein 1 Neighboring gene STARR-seq mESC enhancer starr_27299 Neighboring gene STARR-positive B cell enhancer ABC_E369 Neighboring gene microRNA 1982 Neighboring gene ornithine decarboxylase antizyme 1 Neighboring gene STARR-positive B cell enhancer ABC_E11447 Neighboring gene STARR-positive B cell enhancer ABC_E6885 Neighboring gene LSM7 homolog, U6 small nuclear RNA and mRNA degradation associated Neighboring gene signal peptide peptidase like 2B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Expression of the Lingo/LERN gene family during mouse embryogenesis. Haines BP, et al. Gene Expr Patterns, 2008 Jan. PMID 18297755
    2. Histone methyltransferase Ezh2 coordinates mammalian axon regeneration via regulation of key regenerative pathways. Wang XW, et al. J Clin Invest, 2024 Feb 1. PMID 38015636, Free PMC Article
    3. Expression pattern of LRR and Ig domain-containing protein (LRRIG protein) in the early mouse embryo. Homma S, et al. Gene Expr Patterns, 2009 Jan. PMID 18848646
    4. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
    5. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in extracellular matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 3
    Names
    leucine-rich repeat neuronal protein 6B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001013758.2 → NP_001013780.2  leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 3 precursor

      See identical proteins and their annotated locations for NP_001013780.2

      Status: VALIDATED

      Source sequence(s)
      BC072620, CJ131945
      Consensus CDS
      CCDS24035.1
      UniProtKB/Swiss-Prot
      E9QK50, Q6GQU6
      Related
      ENSMUSP00000054960.8, ENSMUST00000053986.9
      Conserved Domains (6) summary
      TIGR00864
      Location:331 → 405
      PCC; polycystin cation channel protein
      smart00013
      Location:23 → 55
      LRRNT; Leucine rich repeat N-terminal domain
      COG4886
      Location:55 → 353
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      sd00033
      Location:34 → 53
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:246 → 302
      LRR_8; Leucine rich repeat
      pfam07679
      Location:406 → 496
      I-set; Immunoglobulin I-set domain

    2. NM_001359746.1 → NP_001346675.1  leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 3 precursor

      Status: VALIDATED

      Source sequence(s)
      BC072620, CJ070128, CK620157
      Consensus CDS
      CCDS24035.1
      UniProtKB/Swiss-Prot
      E9QK50, Q6GQU6
      Conserved Domains (6) summary
      TIGR00864
      Location:331 → 405
      PCC; polycystin cation channel protein
      smart00013
      Location:23 → 55
      LRRNT; Leucine rich repeat N-terminal domain
      COG4886
      Location:55 → 353
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      sd00033
      Location:34 → 53
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:246 → 302
      LRR_8; Leucine rich repeat
      pfam07679
      Location:406 → 496
      I-set; Immunoglobulin I-set domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      80668635..80679873 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006513623.4 → XP_006513686.1  leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 3 isoform X1

      See identical proteins and their annotated locations for XP_006513686.1

      UniProtKB/Swiss-Prot
      E9QK50, Q6GQU6
      Conserved Domains (6) summary
      TIGR00864
      Location:331 → 405
      PCC; polycystin cation channel protein
      smart00013
      Location:23 → 55
      LRRNT; Leucine rich repeat N-terminal domain
      COG4886
      Location:55 → 353
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      sd00033
      Location:34 → 53
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:246 → 302
      LRR_8; Leucine rich repeat
      pfam07679
      Location:406 → 496
      I-set; Immunoglobulin I-set domain

    2. XM_006513622.5 → XP_006513685.1  leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 3 isoform X1

      See identical proteins and their annotated locations for XP_006513685.1

      UniProtKB/Swiss-Prot
      E9QK50, Q6GQU6
      Conserved Domains (6) summary
      TIGR00864
      Location:331 → 405
      PCC; polycystin cation channel protein
      smart00013
      Location:23 → 55
      LRRNT; Leucine rich repeat N-terminal domain
      COG4886
      Location:55 → 353
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      sd00033
      Location:34 → 53
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:246 → 302
      LRR_8; Leucine rich repeat
      pfam07679
      Location:406 → 496
      I-set; Immunoglobulin I-set domain

    3. XM_006513620.5 → XP_006513683.1  leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 3 isoform X1

      See identical proteins and their annotated locations for XP_006513683.1

      UniProtKB/Swiss-Prot
      E9QK50, Q6GQU6
      Conserved Domains (6) summary
      TIGR00864
      Location:331 → 405
      PCC; polycystin cation channel protein
      smart00013
      Location:23 → 55
      LRRNT; Leucine rich repeat N-terminal domain
      COG4886
      Location:55 → 353
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      sd00033
      Location:34 → 53
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:246 → 302
      LRR_8; Leucine rich repeat
      pfam07679
      Location:406 → 496
      I-set; Immunoglobulin I-set domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6GQU6.2 GenPept UniProtKB/Swiss-Prot:Q6GQU6

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