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    Atp6v0e2 ATPase, H+ transporting, lysosomal V0 subunit E2 [ Mus musculus (house mouse) ]

    Gene ID: 76252, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Atp6v0e2provided by MGI
    Official Full Name
    ATPase, H+ transporting, lysosomal V0 subunit E2provided by MGI
    Primary source
    MGI:MGI:1923502
    See related
    Ensembl:ENSMUSG00000039347 AllianceGenome:MGI:1923502
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    NM9.2; 0610006O14Rik
    Summary
    Predicted to enable proton-transporting ATPase activity, rotational mechanism. Involved in synaptic vesicle lumen acidification. Predicted to be located in clathrin-coated vesicle membrane. Predicted to be part of vacuolar proton-transporting V-type ATPase, V0 domain. Predicted to be active in synaptic vesicle membrane. Is expressed in several structures, including genitourinary system; nervous system; sensory organ; and tongue. Orthologous to human ATP6V0E2 (ATPase H+ transporting V0 subunit e2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in cortex adult (RPKM 116.9), cerebellum adult (RPKM 109.2) and 20 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Atp6v0e2 in Genome Data Viewer
    Location:
    6 B2.3; 6 23.52 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (48514503..48518735)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (48537569..48541801)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene zinc finger protein 862, pseudogene Neighboring gene PEST proteolytic signal containing nuclear protein pseudogene Neighboring gene RIKEN cDNA 1700026J14 gene Neighboring gene STARR-positive B cell enhancer ABC_E9271 Neighboring gene leucine rich repeat containing 61 Neighboring gene retinoic acid receptor responder (tazarotene induced) 2 Neighboring gene predicted gene 5111

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A novel putative M9.2 isoform of V-ATPase expressed in the nervous system. Ueda T, et al. Neuroreport, 2003 Jan 20. PMID 12544825
    2. The Presynaptic v-ATPase Reversibly Disassembles and Thereby Modulates Exocytosis but Is Not Part of the Fusion Machinery. Bodzęta A, et al. Cell Rep, 2017 Aug 8. PMID 28793259
    3. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, et al. Science, 2004 Dec 24. PMID 15618518
    4. GUDMAP: the genitourinary developmental molecular anatomy project. McMahon AP, et al. J Am Soc Nephrol, 2008 Apr. PMID 18287559
    5. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables proton-transporting ATPase activity, rotational mechanism IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables proton-transporting ATPase activity, rotational mechanism ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in proton transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in synaptic vesicle lumen acidification EXP
    Inferred from Experiment
    more info
    		 PubMed 
    involved_in synaptic vesicle lumen acidification IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in synaptic vesicle lumen acidification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in clathrin-coated vesicle membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in synaptic vesicle membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in synaptic vesicle membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of vacuolar proton-transporting V-type ATPase, V0 domain ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    V-type proton ATPase subunit e 2
    Names
    ATPase, H+ transporting, lysosomal, V0 subunit E
    V-ATPase subunit e 2
    vacuolar proton pump subunit e 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001347164.1 → NP_001334093.1  V-type proton ATPase subunit e 2 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate exon in the 3' coding region, which results in a frameshift, compared to variant 1. It encodes isoform 2, which has a longer and distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AC154013
      Consensus CDS
      CCDS85039.1
      UniProtKB/TrEMBL
      A0A0N4SVQ2
      Related
      ENSMUSP00000145198.2, ENSMUST00000203011.2

    2. NM_133764.3 → NP_598525.1  V-type proton ATPase subunit e 2 isoform 1

      See identical proteins and their annotated locations for NP_598525.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript but encodes the shorter isoform (1).
      Source sequence(s)
      AC154013, AI839056, AK077313, BY296901
      Consensus CDS
      CCDS20103.1
      UniProtKB/Swiss-Prot
      Q91XE7
      Related
      ENSMUSP00000044110.6, ENSMUST00000040361.8
      Conserved Domains (1) summary
      pfam05493
      Location:9 → 67
      ATP_synt_H; ATP synthase subunit H

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      48514503..48518735
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q91XE7.1 GenPept UniProtKB/Swiss-Prot:Q91XE7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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