Dstn destrin [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Dstnprovided by MGI
Official Full Name: destrinprovided by MGI
Primary source: MGI:MGI:1929270
See related: Ensembl:ENSMUSG00000015932 AllianceGenome:MGI:1929270
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: ADF; Dsn; corn1; sid23p; 2610043P17Rik
Summary: Enables actin filament binding activity. Involved in actin filament fragmentation. Acts upstream of or within cell motility and positive regulation of actin filament depolymerization. Located in cortical actin cytoskeleton. Is active in glutamatergic synapse; postsynapse; and presynapse. Is expressed in several structures, including genitourinary system; gut; nervous system; sensory organ; and skin. Orthologous to human DSTN (destrin, actin depolymerizing factor). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in bladder adult (RPKM 498.8), large intestine adult (RPKM 115.0) and 14 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 G1; 2 70.89 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (143757251..143785244)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (143915331..143943324)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The actin depolymerizing factor destrin serves as a negative feedback inhibitor of smooth muscle cell differentiation.
Title: The actin depolymerizing factor destrin serves as a negative feedback inhibitor of smooth muscle cell differentiation.
Actin depolymerizing factor (ADF)/cofilin controls actin turnover to sustain axon regeneration after spinal cord injury through its actin-severing activity. This pinpoints ADF/cofilin as a key regulator of axon growth competence, irrespective of developmental stage.
Title: ADF/Cofilin-Mediated Actin Turnover Promotes Axon Regeneration in the Adult CNS.
AGEs treatment increased endothelial permeability and reduced vasculogenic property of MBMECs, at least in part, via downregulation of ADF.
Title: The role of actin depolymerizing factor in advanced glycation endproducts-induced impairment in mouse brain microvascular endothelial cells.
Dstncorn1 mice are homozygous for a spontaneous null actin depolymerizing factor destrin (DSTN) allele, which results in an increase in serum response factor (Srf) expression.This study performs identification of functional pathways associated with the conditional ablation of serum response factor in Dstn corn1 mice.
Title: Identification of functional pathways associated with the conditional ablation of serum response factor in Dstncorn1 mice.
Actin depolymerizing factor/cofilin double mutant mice exhibited hyperlocomotion, impulsivity, and impaired working memory. Hyperlocomotion and impulsive behavior were reversed by methylphenidate.
Title: Attention-Deficit/Hyperactivity Disorder-like Phenotype in a Mouse Model with Impaired Actin Dynamics.
SRF binding is significantly decreased in the destrin (corn1) mutant cornea.
Title: Serum response factor: positive and negative regulation of an epithelial gene expression network in the destrin mutant cornea.
A single QTL is responsible for modification of neovascularization in the Dstn null mutation mouse.
Title: Genetic modification of corneal neovascularization in Dstn (corn1) mice.
findings identify actin-depolymerizing factor (ADF) as a key signaling molecule in the regulation of BBB integrity and suggest that ADF might be used as a target to modulate diseases accompanied by ox-LDL-induced BBB compromise.
Title: Overexpression of actin-depolymerizing factor blocks oxidized low-density lipoprotein-induced mouse brain microvascular endothelial cell barrier dysfunction.
n-cofilin can compensate for the loss of ADF in excitatory synapses. ADF and n-cofilin cooperate in controlling synaptic actin content
Title: N-cofilin can compensate for the loss of ADF in excitatory synapses.
Results indicate that ADF activity, provided by either cofilin1 or destrin, is essential in UB epithelial cells for normal growth and branching.
Title: Actin depolymerizing factors cofilin1 and destrin are required for ureteric bud branching morphogenesis.

Submit: New GeneRIF Correction See all GeneRIFs (16)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Spontaneous (2) 1 citation
Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D2Dcr90 (e-PCR), detects polymorphism
- UniSTS:507649

13.MMHAP61FRE7.seq (e-PCR)
- UniSTS:123175

D2Mit194 (e-PCR), detects polymorphism
- UniSTS:116278

AU042046 (e-PCR)
- UniSTS:159043

RH130919 (e-PCR)
- UniSTS:214203

AW987265 (e-PCR)
- UniSTS:185846

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables actin filament binding	IBA Inferred from Biological aspect of Ancestor more info
enables actin filament binding	IDA Inferred from Direct Assay more info	PubMed
enables actin filament binding	ISO Inferred from Sequence Orthology more info
enables actin filament binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in actin filament depolymerization	IDA Inferred from Direct Assay more info	PubMed
involved_in actin filament depolymerization	ISO Inferred from Sequence Orthology more info
involved_in actin filament fragmentation	IBA Inferred from Biological aspect of Ancestor more info
involved_in actin filament fragmentation	IDA Inferred from Direct Assay more info	PubMed
involved_in actin filament severing	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cell motility	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cytokinesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of actin filament depolymerization	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in actin cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
located_in cortical actin cytoskeleton	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in presynapse	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: destrin

Names: actin-depolymerizing factor; corneal disease 1; sid 23

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.