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    ISPD Nucleotide-diphospho-sugar transferases superfamily protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 814779, updated on 18-Sep-2024

    Summary

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    Official Symbol
    ISPD
    Official Full Name
    Nucleotide-diphospho-sugar transferases superfamily protein
    Primary source
    TAIR:AT2G02500
    Locus tag
    AT2G02500
    See related
    Araport:AT2G02500
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    2-C-METHYL-D-ERYTHRITOL 4-PHOSPHATE CYTIDYLTRANSFERASE; 4-DIPHOSPHOCYTIDYL-2C-METHYL-D-ERYTHRITOL SYNTHASE; ATMEPCT; MCT; T8K22.20; T8K22_20
    Summary
    Encodes a protein with 4-Diphosphocytidyl-2C-methyl-D-erythritol synthase activity. The enzyme has an absolute requirement for divalent cations (Mg2+ reaches the highest catalytic activity).
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    Genomic context

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    See ISPD in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    12
    Sequence:
    Chromosome: 2; NC_003071.7 (670461..673327, complement)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene NADH dehydrogenase (ubiquinone)s Neighboring gene uncharacterized protein Neighboring gene RNA-directed DNA polymerase (reverse transcriptase)-related family protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Biosynthesis of terpenoids: 4-diphosphocytidyl-2C-methyl-D-erythritol synthase of Arabidopsis thaliana. Rohdich F, et al. Proc Natl Acad Sci U S A, 2000 Jun 6. PMID 10841550, Free PMC Article
    2. The crystal structure of a plant 2C-methyl-D-erythritol 4-phosphate cytidylyltransferase exhibits a distinct quaternary structure compared to bacterial homologues and a possible role in feedback regulation for cytidine monophosphate. Gabrielsen M, et al. FEBS J, 2006 Mar. PMID 16478479
    3. The oligomeric stromal proteome of Arabidopsis thaliana chloroplasts. Peltier JB, et al. Mol Cell Proteomics, 2006 Jan. PMID 16207701
    4. Quantitative proteomics of a chloroplast SRP54 sorting mutant and its genetic interactions with CLPC1 in Arabidopsis. Rutschow H, et al. Plant Physiol, 2008 Sep. PMID 18633119, Free PMC Article
    5. AT_CHLORO, a comprehensive chloroplast proteome database with subplastidial localization and curated information on envelope proteins. Ferro M, et al. Mol Cell Proteomics, 2010 Jun. PMID 20061580, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. crystal structure of the catalytic domain
      Title: The crystal structure of a plant 2C-methyl-D-erythritol 4-phosphate cytidylyltransferase exhibits a distinct quaternary structure compared to bacterial homologues and a possible role in feedback regulation for cytidine monophosphate.
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    Pathways from PubChem

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    General gene information

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    NM_001335124.1
    NM_126305.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast HDA PubMed 
    located_in chloroplast stroma HDA PubMed 
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  
    located_in plastid NAS
    Non-traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    Nucleotide-diphospho-sugar transferases superfamily protein
    NP_565286.1
    • ISPD; FUNCTIONS IN: 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity; INVOLVED IN: response to light stimulus, isopentenyl diphosphate biosynthetic process, mevalonate-independent pathway; LOCATED IN: chloroplast, chloroplast stroma, plastid; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: 4-diphosphocytidyl-2C-methyl-D-erythritol synthase (InterPro:IPR001228), 4-diphosphocytidyl-2C-methyl-D-erythritol synthase, conserved site (InterPro:IPR018294); Has 6821 Blast hits to 6815 proteins in 2244 species: Archae - 30; Bacteria - 4964; Metazoa - 52; Fungi - 6; Plants - 61; Viruses - 0; Other Eukaryotes - 1708 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      670461..673327 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_126305.3 → NP_565286.1  Nucleotide-diphospho-sugar transferases superfamily protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_565286.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O64726, P69834, Q9LL91
      UniProtKB/TrEMBL
      A0A7G2EAX7
      Conserved Domains (1) summary
      PLN02728
      Location:55 → 302
      PLN02728; 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase

    2. NM_001335124.1 → NP_001325418.1  Nucleotide-diphospho-sugar transferases superfamily protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O64726, P69834, Q9LL91
      UniProtKB/TrEMBL
      A0A7G2EAX7
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P69834.1

    Gene LinkOut

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