U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    XLG1 extra-large G-protein 1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 816878, updated on 18-Sep-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    XLG1
    Official Full Name
    extra-large G-protein 1
    Primary source
    TAIR:AT2G23460
    Locus tag
    AT2G23460
    See related
    Araport:AT2G23460
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATXLG1; extra-large G-protein 1; F26B6.11; F26B6_11
    Summary
    encodes a novel G-alpha protein that shares similarity to plant, yeast, and animal G-alpha proteins at the C-terminus. It contains an N-terminus that is as large as the C-terminus, is a member of a small family, and is expressed in all tissues examined, including roots, leaves, stems, flowers, and fruits.
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See XLG1 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    7
    Sequence:
    Chromosome: 2; NC_003071.7 (9995465..9999122)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Protein kinase superfamily protein Neighboring gene root UVB sensitive protein (Protein of unknown function, DUF647) Neighboring gene pseudo Neighboring gene pseudo

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Arabidopsis thaliana 'extra-large GTP-binding protein' (AtXLG1): a new class of G-protein. Lee YR, et al. Plant Mol Biol, 1999 May. PMID 10394945
    2. Arabidopsis EXTRA-LARGE G PROTEIN 1 (XLG1) functions together with XLG2 and XLG3 in PAMP-triggered MAPK activation and immunity. Wang Y, et al. J Integr Plant Biol, 2023 Mar. PMID 36250681
    3. Extra-Large G Proteins Expand the Repertoire of Subunits in Arabidopsis Heterotrimeric G Protein Signaling. Chakravorty D, et al. Plant Physiol, 2015 Sep. PMID 26157115, Free PMC Article
    4. Arabidopsis extra-large G proteins (XLGs) regulate root morphogenesis. Ding L, et al. Plant J, 2008 Jan. PMID 17999646
    5. EXTRA-LARGE G PROTEINs Interact with E3 Ligases PUB4 and PUB2 and Function in Cytokinin and Developmental Processes. Wang Y, et al. Plant Physiol, 2017 Feb. PMID 27986866, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Arabidopsis EXTRA-LARGE G PROTEIN 1 (XLG1) functions together with XLG2 and XLG3 in PAMP-triggered MAPK activation and immunity.
      Title: Arabidopsis EXTRA-LARGE G PROTEIN 1 (XLG1) functions together with XLG2 and XLG3 in PAMP-triggered MAPK activation and immunity.
    2. XLG1 interaction with PUB4 and PUB2
      Title: EXTRA-LARGE G PROTEINs Interact with E3 Ligases PUB4 and PUB2 and Function in Cytokinin and Developmental Processes.
    3. XLGs can bind Gbetagamma dimers.
      Title: Extra-Large G Proteins Expand the Repertoire of Subunits in Arabidopsis Heterotrimeric G Protein Signaling.
    4. study describes initial functional characterization of XLG1, XLG2 & XZLG3 genes & reveals a role for XLG proteins in the regulation of root growth and seed germination by sugars and phytohormones
      Title: Arabidopsis extra-large G proteins (XLGs) regulate root morphogenesis.
    Submit: New GeneRIF Correction

    General gene information

    Go to the top of the page Help
    NM_127910.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables G-protein beta/gamma-subunit complex binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTP binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables GTPase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of root morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within response to abscisic acid IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within response to fructose IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within response to glucose IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within response to mannitol IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within response to sucrose IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    extra-large G-protein 1
    NP_565553.1
    • extra-large G-protein 1 (XLG1); FUNCTIONS IN: signal transducer activity, guanyl nucleotide binding; INVOLVED IN: in 7 processes; LOCATED IN: nucleus; EXPRESSED IN: 27 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Guanine nucleotide binding protein (G-protein), alpha subunit (InterPro:IPR001019), G protein alpha subunit, helical insertion (InterPro:IPR011025); BEST Arabidopsis thaliana protein match is: extra-large GTP-binding protein 3 (TAIR:AT1G31930.3); Has 3427 Blast hits to 3422 proteins in 394 species: Archae - 0; Bacteria - 2; Metazoa - 2220; Fungi - 618; Plants - 355; Viruses - 0; Other Eukaryotes - 232 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      9995465..9999122
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_127910.3 → NP_565553.1  extra-large G-protein 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_565553.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O80462, O81224, O81225, Q93Y21
      UniProtKB/TrEMBL
      A0A654EVH5
      Conserved Domains (2) summary
      cd00066
      Location:484 → 864
      G-alpha; Alpha subunit of G proteins (guanine nucleotide binding)
      pfam00503
      Location:485 → 862
      G-alpha; G-protein alpha subunit
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O80462.2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools