HSFA2 heat shock transcription factor A2 [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: HSFA2
Official Full Name: heat shock transcription factor A2
Primary source: TAIR:AT2G26150
Locus tag: AT2G26150
See related: Araport:AT2G26150
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: ATHSFA2; heat shock transcription factor A2; T19L18.4; T19L18_4
Summary: member of Heat Stress Transcription Factor (Hsf) family. Involved in response to misfolded protein accumulation in the cytosol. Regulated by alternative splicing and non-sense-mediated decay.
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Genomic context

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See HSFA2 in Genome Data Viewer

Location:: chromosome: 2

Exon count:: 3

Sequence:: Chromosome: 2; NC_003071.7 (11135624..11137792)

Chromosome 2 - NC_003071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003071.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Early signaling enhance heat tolerance in Arabidopsis through modulating jasmonic acid synthesis mediated by HSFA2.
Title: Early signaling enhance heat tolerance in Arabidopsis through modulating jasmonic acid synthesis mediated by HSFA2.
Letter to the Editor: The Role of HSFA2 in Within-Generational Plasticity and Transgenerational Memory of the Heat-Induced Early Flowering Phenotype in Arabidopsis.
Title: Letter to the Editor: The Role of HSFA2 in Within-Generational Plasticity and Transgenerational Memory of the Heat-Induced Early Flowering Phenotype in Arabidopsis.
Primary carbohydrate metabolism genes participate in heat-stress memory at the shoot apical meristem of Arabidopsis thaliana.
Title: Primary carbohydrate metabolism genes participate in heat-stress memory at the shoot apical meristem of Arabidopsis thaliana.
Heteromeric HSFA2/HSFA3 complexes drive transcriptional memory after heat stress in Arabidopsis.
Title: Heteromeric HSFA2/HSFA3 complexes drive transcriptional memory after heat stress in Arabidopsis.
Transcriptomic analyses revealed that two genes involved in low-oxygen tolerance, namely GLUTAMATE DEHYDROGENASE 1 (GDH1) and GDH2, showed lower expression levels in the stop1 mutant than in the wild-type. Sensitivity of the gdh1gdh2 double-mutant to low-oxygen conditions was partly attributable to the low-oxygen sensitivity of the stop1 mutant.
Title: STOP1 regulates the expression of HsfA2 and GDHs that are critical for low-oxygen tolerance in Arabidopsis.
Study demonstrated the flexible mode of heat response pathways involving bZIP28, HSFA2 and ROS-dependent signals.
Title: Coordination between bZIP28 and HSFA2 in the regulation of heat response signals in Arabidopsis.
LIN treatment rapidly increases the levels of aggregated proteins in the chloroplast, unleashing a specific retrograde signaling pathway that up-regulates expression of ClpB3 and other nuclear genes encoding plastidial chaperones.Expression of HsfA2 and cpUPR-related target genes is independent of GUN1, a central integrator of retrograde signaling pathways
Title: Interference with plastome gene expression and Clp protease activity in Arabidopsis triggers a chloroplast unfolded protein response to restore protein homeostasis.
transcriptional responses of the OPDA-responsive genes HsfA2 and DREB2A to the protein synthesis inhibitor cycloheximide and to the HSP90 inhibitor geldanamycin
Title: Mechanisms of induction of the stress-responsive transcription factors HsfA2 and DREB2A by 12-oxo-phytodienoic acid in Arabidopsis thaliana.
Self-regulation of HsfA2 expression is through a small truncated HsfA2 isoform encoded by the splice variant.
Title: An autoregulatory loop controlling Arabidopsis HsfA2 expression: role of heat shock-induced alternative splicing.
Data indicate that cngc16 mutant pollen have attenuated expression of several heat-stress response genes, including two heat shock transcription factor genes, HsfA2 and HsfB1.
Title: A cyclic nucleotide-gated channel (CNGC16) in pollen is critical for stress tolerance in pollen reproductive development.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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NM_001124916.2

Supported by ESTs:

NM_001336038.1

Supported by ESTs:

NM_001336039.1

Supported by ESTs:

NM_128173.3

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables promoter-specific chromatin binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info
enables transcription cis-regulatory region binding	IDA Inferred from Direct Assay more info	PubMed
enables transcription cis-regulatory region binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within cellular response to heat	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within cellular response to hypoxia	HEP more info	PubMed
acts_upstream_of_or_within cellular response to hypoxia	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within cellular response to unfolded protein	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within cellular response to unfolded protein	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in heat acclimation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of DNA-templated transcription	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to heat	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to heat	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within response to hydrogen peroxide	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within response to hypoxia	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISM Inferred from Sequence Model more info

General protein information

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Preferred Names: heat shock transcription factor A2

NP_001118388.1

heat shock transcription factor A2 (HSFA2); FUNCTIONS IN: DNA binding, transcription activator activity, sequence-specific DNA binding transcription factor activity; INVOLVED IN: in 7 processes; LOCATED IN: endomembrane system, nucleus; EXPRESSED IN: 8 plant structures; EXPRESSED DURING: 4 anthesis, C globular stage, petal differentiation and expansion stage; CONTAINS InterPro DOMAIN/s: Winged helix-turn-helix transcription repressor DNA-binding (InterPro:IPR011991), Heat shock factor (HSF)-type, DNA-binding (InterPro:IPR000232); BEST Arabidopsis thaliana protein match is: heat shock transcription factor A1D (TAIR:AT1G32330.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).

NP_180184.1

heat shock transcription factor A2 (HSFA2); FUNCTIONS IN: DNA binding, transcription activator activity, sequence-specific DNA binding transcription factor activity; INVOLVED IN: in 7 processes; LOCATED IN: nucleus; EXPRESSED IN: 8 plant structures; EXPRESSED DURING: 4 anthesis, C globular stage, petal differentiation and expansion stage; CONTAINS InterPro DOMAIN/s: Winged helix-turn-helix transcription repressor DNA-binding (InterPro:IPR011991), Heat shock factor (HSF)-type, DNA-binding (InterPro:IPR000232); BEST Arabidopsis thaliana protein match is: heat shock transcription factor A6B (TAIR:AT3G22830.1); Has 2162 Blast hits to 2147 proteins in 231 species: Archae - 0; Bacteria - 0; Metazoa - 326; Fungi - 474; Plants - 849; Viruses - 0; Other Eukaryotes - 513 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003071.7 Reference assembly

Range

11135624..11137792

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001124916.2 → NP_001118388.1 heat shock transcription factor A2 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_001118388.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A178VQK8, B3H5P6

Conserved Domains (1) summary

cl12113
Location:49 → 79

HSF_DNA-bind; HSF-type DNA-binding
NM_128173.3 → NP_180184.1 heat shock transcription factor A2 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_180184.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O80982

UniProtKB/TrEMBL

A0A178VQJ6

Conserved Domains (1) summary

smart00415
Location:41 → 134

HSF; heat shock factor
NM_001336038.1 → NP_001324814.1 heat shock transcription factor A2 [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/TrEMBL

A0A178VQK8, B3H5P6
NM_001336039.1 → NP_001324815.1 heat shock transcription factor A2 [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/Swiss-Prot

O80982

UniProtKB/TrEMBL

A0A178VQJ6