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    PLA2-ALPHA Phospholipase A2 family protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 815261, updated on 18-Sep-2024

    Summary

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    Official Symbol
    PLA2-ALPHA
    Official Full Name
    Phospholipase A2 family protein
    Primary source
    TAIR:AT2G06925
    Locus tag
    AT2G06925
    See related
    Araport:AT2G06925
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATSPLA2-ALPHA; PHOSPHOLIPASE A2-ALPHA
    Summary
    Encodes a secretory phospholipase A2 enzyme, which specifically hydrolyzes the sn-2 position of phospholipids. The enzyme has a preference towards linoleoyl acyl chain over palmitoyl acyl chain. It also has a slight preference for phosphatidylcholine over phosphatidylethanolamine.
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    Genomic context

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    See PLA2-ALPHA in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    4
    Sequence:
    Chromosome: 2; NC_003071.7 (2842020..2843386, complement)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene pseudo Neighboring gene pseudo Neighboring gene miscRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Probing selected structural regions in the secreted phospholipase A₂ from Arabidopsis thaliana for their impact on stability and activity. Mansfeld J, et al. Biochimie, 2014 Jun. PMID 24389456
    2. The patatin-containing phospholipase A pPLAIIα modulates oxylipin formation and water loss in Arabidopsis thaliana. Yang WY, et al. Mol Plant, 2012 Mar. PMID 22259021, Free PMC Article
    3. Secretory phospholipase A2-alpha from Arabidopsis thaliana: functional parameters and substrate preference. Mansfeld J, et al. Chem Phys Lipids, 2007 Dec. PMID 17692835
    4. A mutation in the pPLA-IIα gene encoding PATATIN-RELATED PHOSPHOLIPASE a causes late flowering in Arabidopsis. Kwak JS, et al. Biochem Biophys Res Commun, 2021 Dec 10. PMID 34678591
    5. AtsPLA2-alpha nuclear relocalization by the Arabidopsis transcription factor AtMYB30 leads to repression of the plant defense response. Froidure S, et al. Proc Natl Acad Sci U S A, 2010 Aug 24. PMID 20696912, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A mutation in the pPLA-IIalpha gene encoding PATATIN-RELATED PHOSPHOLIPASE a causes late flowering in Arabidopsis.
      Title: A mutation in the pPLA-IIα gene encoding PATATIN-RELATED PHOSPHOLIPASE a causes late flowering in Arabidopsis.
    2. Extended loop structures at the N-terminus in AtPLA2alpha are suggested to be the main reasons for the much lower thermodynamic stability compared with its homologues.
      Title: Probing selected structural regions in the secreted phospholipase A₂ from Arabidopsis thaliana for their impact on stability and activity.
    3. These results indicate that pPLAIIalpha negatively regulates oxylipin production and suggest a role in the removal of oxidatively modified fatty acids from membranes.
      Title: The patatin-containing phospholipase A pPLAIIα modulates oxylipin formation and water loss in Arabidopsis thaliana.
    4. AtMYB30 and the secreted phospholipase AtsPLA(2)-alpha physically interact in vivo, following the AtMYB30-mediated specific relocalization of AtsPLA(2)-alpha from cytoplasmic vesicles to the plant cell nucleus.
      Title: AtsPLA2-alpha nuclear relocalization by the Arabidopsis transcription factor AtMYB30 leads to repression of the plant defense response.
    5. analysis of secretory phospholipase A2-alpha from Arabidopsis thaliana
      Title: Secretory phospholipase A2-alpha from Arabidopsis thaliana: functional parameters and substrate preference.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Homology

    NM_001335309.1
    NM_126670.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phospholipase A2 activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables phospholipase A2 activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in arachidonate secretion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in lipid catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in phospholipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular region ISM
    Inferred from Sequence Model
    more info
    		  
    located_in vacuole TAS
    Traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Phospholipase A2 family protein
    NP_565337.1
    • PLA2-ALPHA; FUNCTIONS IN: phospholipase A2 activity; INVOLVED IN: phospholipid metabolic process, lipid catabolic process; LOCATED IN: vacuole; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Phospholipase A2 (InterPro:IPR016090), Phospholipase A2, active site (InterPro:IPR013090), Phospholipase A2, eukaryotic (InterPro:IPR001211); BEST Arabidopsis thaliana protein match is: Phospholipase A2 family protein (TAIR:AT4G29470.1); Has 123 Blast hits to 123 proteins in 26 species: Archae - 0; Bacteria - 0; Metazoa - 13; Fungi - 0; Plants - 110; Viruses - 0; Other Eukaryotes - 0 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      2842020..2843386 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_126670.3 → NP_565337.1  Phospholipase A2 family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_565337.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8S8N6
      UniProtKB/TrEMBL
      A0A178VVH8, A0A5S9WXI3
      Conserved Domains (1) summary
      cd04706
      Location:32 → 148
      PLA2_plant; Plant-specific sub-family of Phospholipase A2, a super-family of secretory and cytosolic enzymes; the latter are either Ca dependent or Ca independent. Enzymatically active PLA2 cleaves the sn-2 position of the glycerol backbone of phospholipids; ...

    2. NM_001335309.1 → NP_001324649.1  Phospholipase A2 family protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8B0P3, A0A7G2E8E6
      Conserved Domains (1) summary
      cd04706
      Location:32 → 142
      PLA2_plant; Plant-specific sub-family of Phospholipase A2, a super-family of secretory and cytosolic enzymes; the latter are either Ca dependent or Ca independent. Enzymatically active PLA2 cleaves the sn-2 position of the glycerol backbone of phospholipids; ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8S8N6.1

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