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    PUB12 armadillo/beta-catenin repeat protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 817432, updated on 18-Sep-2024

    Summary

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    Official Symbol
    PUB12
    Official Full Name
    armadillo/beta-catenin repeat protein
    Primary source
    TAIR:AT2G28830
    Locus tag
    AT2G28830
    See related
    Araport:AT2G28830
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    AtPUB12; F8N16.12; F8N16_12; PLANT U-BOX 12
    Summary
    Encodes a U-box E3 ubiquitin ligase involved in ubiquitination of pattern recognition receptor FLS2.
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    Genomic context

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    See PUB12 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    4
    Sequence:
    Chromosome: 2; NC_003071.7 (12368220..12370420, complement)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene Dof-type zinc finger DNA-binding family protein Neighboring gene 50S ribosomal protein L16 Neighboring gene uncharacterized protein Neighboring gene cytochrome P450, family 710, subfamily A, polypeptide 3

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Regulation of Arabidopsis brassinosteroid receptor BRI1 endocytosis and degradation by plant U-box PUB12/PUB13-mediated ubiquitination. Zhou J, et al. Proc Natl Acad Sci U S A, 2018 Feb 20. PMID 29432171, Free PMC Article
    2. Arabidopsis ubiquitin ligase PUB12 interacts with and negatively regulates Chitin Elicitor Receptor Kinase 1 (CERK1). Yamaguchi K, et al. PLoS One, 2017. PMID 29182677, Free PMC Article
    3. Degradation of the ABA co-receptor ABI1 by PUB12/13 U-box E3 ligases. Kong L, et al. Nat Commun, 2015 Oct 20. PMID 26482222, Free PMC Article
    4. Direct ubiquitination of pattern recognition receptor FLS2 attenuates plant innate immunity. Lu D, et al. Science, 2011 Jun 17. PMID 21680842, Free PMC Article
    5. The dominant negative ARM domain uncovers multiple functions of PUB13 in Arabidopsis immunity, flowering, and senescence. Zhou J, et al. J Exp Bot, 2015 Jun. PMID 25873653, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Loss of PUB12 and PUB13 results in reduced BRI1 ubiquitination and internalization.
      Title: Regulation of Arabidopsis brassinosteroid receptor BRI1 endocytosis and degradation by plant U-box PUB12/PUB13-mediated ubiquitination.
    2. co-expression of PUB12 in Nicotiana benthamiana reduced the accumulation of CERK1. The pub12 pub13 mutant exhibited enhanced chitin-induced immune responses such as ROS production, MAPK activation, and callose deposition
      Title: Arabidopsis ubiquitin ligase PUB12 interacts with and negatively regulates Chitin Elicitor Receptor Kinase 1 (CERK1).
    3. ABI1 (ABA-INSENSITIVE 1) can interact with the U-box E3 ligases PUB12 and PUB13, but is ubiquitinated only when it interacts with ABA receptors in an in vitro assay.
      Title: Degradation of the ABA co-receptor ABI1 by PUB12/13 U-box E3 ligases.
    4. The resemblance between PUB13ARM transgenic plants and the pub12pub13 mutant provides genetic evidence that ectopic expression of the PUB ARM domain serves as an alternative approach to dissect the overlapping functions of closely related PUB genes.
      Title: The dominant negative ARM domain uncovers multiple functions of PUB13 in Arabidopsis immunity, flowering, and senescence.
    5. study has revealed a unique regulatory circuit of direct ubiquitination and turnover of FLS2 by BAK1-mediated phosphorylation and recruitment of specific E3 ligases (PUB12,PUB13) for attenuation of immune signaling
      Title: Direct ubiquitination of pattern recognition receptor FLS2 attenuates plant innate immunity.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_001336190.1

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables ubiquitin-protein transferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within defense response to bacterium IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of immune response IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    armadillo/beta-catenin repeat protein
    NP_001318308.1
    • PLANT U-BOX 12 (PUB12); FUNCTIONS IN: ubiquitin-protein ligase activity, structural constituent of ribosome, rRNA binding, binding; INVOLVED IN: response to chitin; LOCATED IN: ubiquitin ligase complex, ribosome, intracellular; EXPRESSED IN: 21 plant structures; EXPRESSED DURING: 9 growth stages; CONTAINS InterPro DOMAIN/s: Ribosomal protein L16 (InterPro:IPR000114), U box domain (InterPro:IPR003613), Armadillo-like helical (InterPro:IPR011989), Ribosomal protein L10e/L16 (InterPro:IPR016180), Armadillo (InterPro:IPR000225), Armadillo-type fold (InterPro:IPR016024), Ribosomal protein L16, conserved site (InterPro:IPR020798); BEST Arabidopsis thaliana protein match is: plant U-box 13 (TAIR:AT3G46510.1); Has 16927 Blast hits to 15027 proteins in 4135 species: Archae - 0; Bacteria - 5491; Metazoa - 1535; Fungi - 908; Plants - 5936; Viruses - 3; Other Eukaryotes - 3054 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      12368220..12370420 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001336190.1 → NP_001318308.1  armadillo/beta-catenin repeat protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      F4IJM7, Q94C99, Q9ZV31
      UniProtKB/TrEMBL
      A0A654EX34
    Nucleotide Protein
    Heading Accession and Version

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