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    CKS1 cyclin-dependent kinase-subunit 1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 817340, updated on 18-Sep-2024

    Summary

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    Official Symbol
    CKS1
    Official Full Name
    cyclin-dependent kinase-subunit 1
    Primary source
    TAIR:AT2G27960
    Locus tag
    AT2G27960
    See related
    Araport:AT2G27960
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    CATALYTIC SUBUNIT OF CYCLIN-DEPENDENT KINASE; CKS1AT; cyclin-dependent kinase-subunit 1; P10CKS1AT; T1E2.12; T1E2_12
    Summary
    catalytic subunit of cyclin dependent kinase 1. physically interact with cyclin-dependent kinases (CDKs) and play an essential, but yet not entirely resolved, role in the regulation of the cell cycle
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    Genomic context

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    See CKS1 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    3
    Sequence:
    Chromosome: 2; NC_003071.7 (11910569..11911802, complement)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene RING/U-box superfamily protein Neighboring gene Ring/U-Box superfamily protein Neighboring gene Acyl-CoA N-acyltransferase with RING/FYVE/PHD-type zinc finger domain-containing protein Neighboring gene CDK-subunit 2 Neighboring gene BEL1-like homeodomain 8

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. CKS1At overexpression in Arabidopsis thaliana inhibits growth by reducing meristem size and inhibiting cell-cycle progression. De Veylder L, et al. Plant J, 2001 Mar. PMID 11319029
    2. Expression of CKS1At in Arabidopsis thaliana indicates a role for the protein in both the mitotic and the endoreduplication cycle. Jacqmard A, et al. Planta, 1999 Feb. PMID 10093894
    3. The Arabidopsis Cks1At protein binds the cyclin-dependent kinases Cdc2aAt and Cdc2bAt. De Veylder L, et al. FEBS Lett, 1997 Aug 4. PMID 9276444
    4. Identification of novel cyclin-dependent kinases interacting with the CKS1 protein of Arabidopsis. Boudolf V, et al. J Exp Bot, 2001 Jun. PMID 11432958
    5. Arabidopsis D-type cyclin CYCD4;1 is a novel cyclin partner of B2-type cyclin-dependent kinase. Kono A, et al. Plant Physiol, 2003 Jul. PMID 12857813, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_128355.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables cyclin-dependent protein serine/threonine kinase regulator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA endoreduplication IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    NOT involved_in DNA endoreduplication IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within mitotic cell cycle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  
    located_in peroxisome HDA PubMed 

    General protein information

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    Preferred Names
    cyclin-dependent kinase-subunit 1
    NP_180363.1
    • cyclin-dependent kinase-subunit 1 (CKS1); CONTAINS InterPro DOMAIN/s: Cyclin-dependent kinase, regulatory subunit (InterPro:IPR000789); BEST Arabidopsis thaliana protein match is: CDK-subunit 2 (TAIR:AT2G27970.1); Has 657 Blast hits to 657 proteins in 207 species: Archae - 0; Bacteria - 0; Metazoa - 305; Fungi - 139; Plants - 105; Viruses - 0; Other Eukaryotes - 108 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      11910569..11911802 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_128355.3 → NP_180363.1  cyclin-dependent kinase-subunit 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_180363.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O23249
      UniProtKB/TrEMBL
      A0A178VPG9, A0A5S9X202
      Conserved Domains (1) summary
      PLN00010
      Location:1 → 71
      PLN00010; cyclin-dependent kinases regulatory subunit; Provisional
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O23249.1

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